Fluorine in PDB 3ohm: Crystal Structure of Activated G Alpha Q Bound to Its Effector Phospholipase C Beta 3
Enzymatic activity of Crystal Structure of Activated G Alpha Q Bound to Its Effector Phospholipase C Beta 3
All present enzymatic activity of Crystal Structure of Activated G Alpha Q Bound to Its Effector Phospholipase C Beta 3:
3.1.4.11;
Protein crystallography data
The structure of Crystal Structure of Activated G Alpha Q Bound to Its Effector Phospholipase C Beta 3, PDB code: 3ohm
was solved by
G.L.Waldo,
J.Sondek,
T.K.Harden,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
50.00 /
2.70
|
Space group
|
C 1 2 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
202.988,
90.881,
93.140,
90.00,
101.16,
90.00
|
R / Rfree (%)
|
20.4 /
27.5
|
Other elements in 3ohm:
The structure of Crystal Structure of Activated G Alpha Q Bound to Its Effector Phospholipase C Beta 3 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Activated G Alpha Q Bound to Its Effector Phospholipase C Beta 3
(pdb code 3ohm). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the
Crystal Structure of Activated G Alpha Q Bound to Its Effector Phospholipase C Beta 3, PDB code: 3ohm:
Jump to Fluorine binding site number:
1;
2;
3;
4;
Fluorine binding site 1 out
of 4 in 3ohm
Go back to
Fluorine Binding Sites List in 3ohm
Fluorine binding site 1 out
of 4 in the Crystal Structure of Activated G Alpha Q Bound to Its Effector Phospholipase C Beta 3
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Activated G Alpha Q Bound to Its Effector Phospholipase C Beta 3 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F401
b:54.9
occ:1.00
|
F1
|
A:ALF401
|
0.0
|
54.9
|
1.0
|
AL
|
A:ALF401
|
1.8
|
49.2
|
1.0
|
NH1
|
A:ARG183
|
2.5
|
56.0
|
1.0
|
F4
|
A:ALF401
|
2.6
|
48.1
|
1.0
|
F3
|
A:ALF401
|
2.6
|
49.4
|
1.0
|
O3B
|
A:GDP400
|
2.6
|
48.6
|
1.0
|
O
|
A:HOH437
|
2.8
|
39.9
|
1.0
|
MG
|
A:MG402
|
3.0
|
52.9
|
1.0
|
NH2
|
A:ARG183
|
3.0
|
57.3
|
1.0
|
N
|
A:THR186
|
3.0
|
53.7
|
1.0
|
CZ
|
A:ARG183
|
3.1
|
55.1
|
1.0
|
CA
|
A:PRO185
|
3.2
|
53.1
|
1.0
|
F2
|
A:ALF401
|
3.5
|
52.5
|
1.0
|
C
|
A:PRO185
|
3.6
|
52.8
|
1.0
|
PB
|
A:GDP400
|
3.6
|
50.8
|
1.0
|
OG1
|
A:THR186
|
3.6
|
53.9
|
1.0
|
O2B
|
A:GDP400
|
3.7
|
43.6
|
1.0
|
O2A
|
A:GDP400
|
3.7
|
42.0
|
1.0
|
CB
|
A:PRO185
|
3.9
|
53.5
|
1.0
|
CA
|
A:THR186
|
4.2
|
54.4
|
1.0
|
CB
|
A:THR186
|
4.2
|
54.5
|
1.0
|
O
|
A:VAL184
|
4.2
|
53.7
|
1.0
|
O3A
|
A:GDP400
|
4.2
|
46.7
|
1.0
|
N
|
A:PRO185
|
4.3
|
52.7
|
1.0
|
O
|
A:HOH436
|
4.3
|
48.9
|
1.0
|
NE
|
A:ARG183
|
4.3
|
57.0
|
1.0
|
C
|
A:VAL184
|
4.5
|
53.1
|
1.0
|
PA
|
A:GDP400
|
4.6
|
44.9
|
1.0
|
O
|
A:PRO185
|
4.7
|
52.1
|
1.0
|
N
|
A:GLU49
|
4.7
|
54.5
|
1.0
|
OE1
|
A:GLN209
|
4.9
|
43.5
|
1.0
|
CG
|
A:PRO185
|
4.9
|
53.0
|
1.0
|
OG
|
A:SER53
|
4.9
|
53.5
|
1.0
|
O
|
A:THR186
|
4.9
|
56.5
|
1.0
|
O1B
|
A:GDP400
|
5.0
|
47.0
|
1.0
|
|
Fluorine binding site 2 out
of 4 in 3ohm
Go back to
Fluorine Binding Sites List in 3ohm
Fluorine binding site 2 out
of 4 in the Crystal Structure of Activated G Alpha Q Bound to Its Effector Phospholipase C Beta 3
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Activated G Alpha Q Bound to Its Effector Phospholipase C Beta 3 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F401
b:52.5
occ:1.00
|
F2
|
A:ALF401
|
0.0
|
52.5
|
1.0
|
AL
|
A:ALF401
|
1.7
|
49.2
|
1.0
|
O
|
A:HOH437
|
2.3
|
39.9
|
1.0
|
F4
|
A:ALF401
|
2.4
|
48.1
|
1.0
|
F3
|
A:ALF401
|
2.5
|
49.4
|
1.0
|
N
|
A:GLY208
|
2.5
|
59.7
|
1.0
|
O3B
|
A:GDP400
|
2.6
|
48.6
|
1.0
|
NZ
|
A:LYS52
|
3.1
|
49.2
|
1.0
|
CA
|
A:GLY208
|
3.2
|
60.1
|
1.0
|
CE
|
A:LYS52
|
3.2
|
50.8
|
1.0
|
CA
|
A:GLY48
|
3.4
|
54.9
|
1.0
|
C
|
A:GLY207
|
3.5
|
59.6
|
1.0
|
F1
|
A:ALF401
|
3.5
|
54.9
|
1.0
|
CA
|
A:GLY207
|
3.7
|
60.1
|
1.0
|
OE1
|
A:GLN209
|
3.7
|
43.5
|
1.0
|
PB
|
A:GDP400
|
3.9
|
50.8
|
1.0
|
N
|
A:GLU49
|
4.0
|
54.5
|
1.0
|
C
|
A:GLY208
|
4.2
|
60.2
|
1.0
|
N
|
A:GLY48
|
4.2
|
55.1
|
1.0
|
O1B
|
A:GDP400
|
4.2
|
47.0
|
1.0
|
O
|
A:HOH436
|
4.2
|
48.9
|
1.0
|
C
|
A:GLY48
|
4.3
|
54.4
|
1.0
|
O2B
|
A:GDP400
|
4.3
|
43.6
|
1.0
|
N
|
A:GLN209
|
4.3
|
59.8
|
1.0
|
CD
|
A:GLN209
|
4.3
|
52.0
|
1.0
|
O
|
A:VAL206
|
4.3
|
60.2
|
1.0
|
NE2
|
A:GLN209
|
4.3
|
47.1
|
1.0
|
O
|
A:THR47
|
4.4
|
55.6
|
1.0
|
C
|
A:THR47
|
4.6
|
55.0
|
1.0
|
MG
|
A:MG402
|
4.6
|
52.9
|
1.0
|
O
|
A:GLY207
|
4.6
|
59.3
|
1.0
|
CD
|
A:LYS52
|
4.8
|
52.6
|
1.0
|
N
|
A:GLY207
|
4.9
|
60.6
|
1.0
|
CB
|
A:THR186
|
4.9
|
54.5
|
1.0
|
OG1
|
A:THR186
|
5.0
|
53.9
|
1.0
|
N
|
A:THR186
|
5.0
|
53.7
|
1.0
|
O
|
A:THR186
|
5.0
|
56.5
|
1.0
|
|
Fluorine binding site 3 out
of 4 in 3ohm
Go back to
Fluorine Binding Sites List in 3ohm
Fluorine binding site 3 out
of 4 in the Crystal Structure of Activated G Alpha Q Bound to Its Effector Phospholipase C Beta 3
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Activated G Alpha Q Bound to Its Effector Phospholipase C Beta 3 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F401
b:49.4
occ:1.00
|
F3
|
A:ALF401
|
0.0
|
49.4
|
1.0
|
AL
|
A:ALF401
|
1.8
|
49.2
|
1.0
|
O
|
A:HOH436
|
2.1
|
48.9
|
1.0
|
MG
|
A:MG402
|
2.3
|
52.9
|
1.0
|
O
|
A:HOH437
|
2.4
|
39.9
|
1.0
|
O3B
|
A:GDP400
|
2.5
|
48.6
|
1.0
|
F2
|
A:ALF401
|
2.5
|
52.5
|
1.0
|
OG1
|
A:THR186
|
2.5
|
53.9
|
1.0
|
F1
|
A:ALF401
|
2.6
|
54.9
|
1.0
|
O2B
|
A:GDP400
|
2.7
|
43.6
|
1.0
|
CB
|
A:THR186
|
2.9
|
54.5
|
1.0
|
PB
|
A:GDP400
|
3.2
|
50.8
|
1.0
|
N
|
A:THR186
|
3.5
|
53.7
|
1.0
|
F4
|
A:ALF401
|
3.6
|
48.1
|
1.0
|
CE
|
A:LYS52
|
3.6
|
50.8
|
1.0
|
O
|
A:VAL206
|
3.7
|
60.2
|
1.0
|
OG
|
A:SER53
|
3.7
|
53.5
|
1.0
|
CA
|
A:THR186
|
3.8
|
54.4
|
1.0
|
CA
|
A:GLY207
|
4.1
|
60.1
|
1.0
|
NZ
|
A:LYS52
|
4.1
|
49.2
|
1.0
|
CG2
|
A:THR186
|
4.2
|
52.4
|
1.0
|
O1B
|
A:GDP400
|
4.2
|
47.0
|
1.0
|
N
|
A:GLY208
|
4.3
|
59.7
|
1.0
|
O
|
A:THR186
|
4.5
|
56.5
|
1.0
|
C
|
A:THR186
|
4.6
|
55.7
|
1.0
|
O3A
|
A:GDP400
|
4.6
|
46.7
|
1.0
|
C
|
A:VAL206
|
4.6
|
60.7
|
1.0
|
C
|
A:PRO185
|
4.7
|
52.8
|
1.0
|
OD1
|
A:ASP205
|
4.7
|
71.1
|
1.0
|
NH1
|
A:ARG183
|
4.7
|
56.0
|
1.0
|
C
|
A:GLY207
|
4.8
|
59.6
|
1.0
|
O2A
|
A:GDP400
|
4.8
|
42.0
|
1.0
|
CB
|
A:SER53
|
4.8
|
54.4
|
1.0
|
N
|
A:GLY207
|
4.8
|
60.6
|
1.0
|
CD
|
A:LYS52
|
4.9
|
52.6
|
1.0
|
|
Fluorine binding site 4 out
of 4 in 3ohm
Go back to
Fluorine Binding Sites List in 3ohm
Fluorine binding site 4 out
of 4 in the Crystal Structure of Activated G Alpha Q Bound to Its Effector Phospholipase C Beta 3
Mono view
Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Activated G Alpha Q Bound to Its Effector Phospholipase C Beta 3 within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F401
b:48.1
occ:1.00
|
F4
|
A:ALF401
|
0.0
|
48.1
|
1.0
|
AL
|
A:ALF401
|
1.8
|
49.2
|
1.0
|
F2
|
A:ALF401
|
2.4
|
52.5
|
1.0
|
O3B
|
A:GDP400
|
2.5
|
48.6
|
1.0
|
F1
|
A:ALF401
|
2.6
|
54.9
|
1.0
|
O
|
A:HOH437
|
2.9
|
39.9
|
1.0
|
N
|
A:GLU49
|
2.9
|
54.5
|
1.0
|
NE2
|
A:GLN209
|
3.0
|
47.1
|
1.0
|
NH2
|
A:ARG183
|
3.0
|
57.3
|
1.0
|
CA
|
A:GLY48
|
3.2
|
54.9
|
1.0
|
OE1
|
A:GLN209
|
3.4
|
43.5
|
1.0
|
NH1
|
A:ARG183
|
3.5
|
56.0
|
1.0
|
C
|
A:GLY48
|
3.6
|
54.4
|
1.0
|
F3
|
A:ALF401
|
3.6
|
49.4
|
1.0
|
CD
|
A:GLN209
|
3.6
|
52.0
|
1.0
|
CZ
|
A:ARG183
|
3.7
|
55.1
|
1.0
|
CA
|
A:GLU49
|
3.9
|
55.6
|
1.0
|
PB
|
A:GDP400
|
4.0
|
50.8
|
1.0
|
CG
|
A:GLU49
|
4.3
|
58.0
|
1.0
|
O
|
A:HOH382
|
4.5
|
48.5
|
1.0
|
N
|
A:GLY48
|
4.6
|
55.1
|
1.0
|
N
|
A:GLY208
|
4.6
|
59.7
|
1.0
|
CB
|
A:GLU49
|
4.7
|
55.6
|
1.0
|
O3A
|
A:GDP400
|
4.7
|
46.7
|
1.0
|
O
|
A:GLY48
|
4.8
|
53.1
|
1.0
|
NZ
|
A:LYS52
|
4.8
|
49.2
|
1.0
|
O1B
|
A:GDP400
|
4.8
|
47.0
|
1.0
|
O2B
|
A:GDP400
|
4.8
|
43.6
|
1.0
|
N
|
A:THR186
|
4.8
|
53.7
|
1.0
|
MG
|
A:MG402
|
5.0
|
52.9
|
1.0
|
|
Reference:
G.L.Waldo,
T.K.Ricks,
S.N.Hicks,
M.L.Cheever,
T.Kawano,
K.Tsuboi,
X.Wang,
C.Montell,
T.Kozasa,
J.Sondek,
T.K.Harden.
Kinetic Scaffolding Mediated By A Phospholipase C-{Beta} and Gq Signaling Complex. Science V. 330 974 2010.
ISSN: ISSN 0036-8075
PubMed: 20966218
DOI: 10.1126/SCIENCE.1193438
Page generated: Sun Dec 13 11:52:20 2020
|