Fluorine in PDB 7jn3: Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048

All present enzymatic activity of Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048:
2.7.7.49; 2.7.7.7; 3.1.26.4;

The structure of Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048 also contains other interesting chemical elements:

Zinc	(Zn)	2 atoms
Magnesium	(Mg)	4 atoms
Chlorine	(Cl)	2 atoms

The binding sites of Fluorine atom in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048 (pdb code 7jn3). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048, PDB code: 7jn3:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048 within 5.0Å range: probe atom residue distance (Å) B Occ A:F302 b:53.6 occ:1.00 FAH A:ZZX302 0.0 53.6 1.0 CAT A:ZZX302 1.3 53.6 1.0 CAV A:ZZX302 2.4 53.6 1.0 CAJ A:ZZX302 2.4 53.6 1.0 CLAI A:ZZX302 2.9 53.6 1.0 CG A:GLN151 3.2 52.2 1.0 CAK A:ZZX302 3.6 53.6 1.0 CAL A:ZZX302 3.6 53.6 1.0 N2 I:DG4 3.8 44.5 1.0 C2 I:DG4 3.9 44.5 1.0 N1 I:DG4 3.9 44.5 1.0 CB A:GLN151 4.0 52.2 1.0 CAU A:ZZX302 4.1 53.6 1.0 O A:SER150 4.3 51.5 1.0 CD A:GLN151 4.3 52.2 1.0 NE2 A:GLN151 4.4 52.2 1.0 CA A:GLN151 4.4 52.2 1.0 N4 J:DC35 4.5 52.3 1.0 N3 I:DG4 4.5 44.5 1.0 C6 I:DG4 4.5 44.5 1.0 C4 J:DC35 4.6 52.3 1.0 C5 J:DC35 4.7 52.3 1.0 C A:SER150 4.9 51.5 1.0

Fluorine binding site 2 out of 2 in the Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048 within 5.0Å range: probe atom residue distance (Å) B Occ E:F302 b:69.2 occ:1.00 FAH E:ZZX302 0.0 69.2 1.0 CAT E:ZZX302 1.4 69.2 1.0 CAV E:ZZX302 2.4 69.2 1.0 CAJ E:ZZX302 2.4 69.2 1.0 CLAI E:ZZX302 2.9 69.2 1.0 CG E:GLN151 3.3 55.5 1.0 N2 K:DG4 3.5 98.0 1.0 N1 K:DG4 3.6 98.0 1.0 C2 K:DG4 3.6 98.0 1.0 CAL E:ZZX302 3.6 69.2 1.0 CAK E:ZZX302 3.6 69.2 1.0 CB E:GLN151 4.0 55.5 1.0 N4 L:DC35 4.0 59.4 1.0 CAU E:ZZX302 4.1 69.2 1.0 O E:SER150 4.2 60.8 1.0 C4 L:DC35 4.3 59.4 1.0 CA E:GLN151 4.3 55.5 1.0 C6 K:DG4 4.3 98.0 1.0 N3 K:DG4 4.4 98.0 1.0 C5 L:DC35 4.5 59.4 1.0 CD E:GLN151 4.6 55.5 1.0 NE2 E:GLN151 4.7 55.5 1.0 O6 K:DG4 4.8 98.0 1.0 N3 L:DC35 4.8 59.4 1.0 C E:SER150 4.8 60.8 1.0 C4 K:DG4 5.0 98.0 1.0

K.K.Pandey, S.Bera, K.Shi, H.Aihara, D.P.Grandgenett, M.J.Rau, A.V.Oleru, J.A.J.Fitzpatrick, A.N.Engelman. Cryo-Em Structure of Rous Sarcoma Virus Cleaved Synaptic Complex (Csc) with Hiv-1 Integrase Strand Transfer Inhibitor Mk-2048 Commun Biol 2021.
ISSN: ESSN 2399-3642
DOI: 10.1038/S42003-021-01855-2