Fluorine in PDB 7kjw: Structure of Hiv-1 Reverse Transcriptase Initiation Complex Core with Efavirenz

Enzymatic activity of Structure of Hiv-1 Reverse Transcriptase Initiation Complex Core with Efavirenz

All present enzymatic activity of Structure of Hiv-1 Reverse Transcriptase Initiation Complex Core with Efavirenz:
2.7.7.49; 2.7.7.7; 3.1.26.13;

Other elements in 7kjw:

The structure of Structure of Hiv-1 Reverse Transcriptase Initiation Complex Core with Efavirenz also contains other interesting chemical elements:

Magnesium (Mg) 1 atom
Chlorine (Cl) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Structure of Hiv-1 Reverse Transcriptase Initiation Complex Core with Efavirenz (pdb code 7kjw). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Structure of Hiv-1 Reverse Transcriptase Initiation Complex Core with Efavirenz, PDB code: 7kjw:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in 7kjw

Go back to Fluorine Binding Sites List in 7kjw
Fluorine binding site 1 out of 3 in the Structure of Hiv-1 Reverse Transcriptase Initiation Complex Core with Efavirenz


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Hiv-1 Reverse Transcriptase Initiation Complex Core with Efavirenz within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F602

b:20.0
occ:1.00
 F1 A:EFZ602 0.0 20.0 1.0
C13 A:EFZ602 1.4 20.0 1.0
F3 A:EFZ602 2.3 20.0 1.0
F2 A:EFZ602 2.3 20.0 1.0
C7 A:EFZ602 2.4 20.0 1.0
O2 A:EFZ602 2.8 20.0 1.0
C8 A:EFZ602 2.8 20.0 1.0
CG1 A:VAL179 3.4 36.6 1.0
O A:VAL179 3.6 36.6 1.0
O A:TYR188 3.6 36.9 1.0
C9 A:EFZ602 3.6 20.0 1.0
CB A:TYR181 3.6 37.1 1.0
C14 A:EFZ602 3.6 20.0 1.0
C6 A:EFZ602 3.7 20.0 1.0
N A:TYR181 3.9 37.1 1.0
O1 A:EFZ602 4.1 20.0 1.0
N A:GLY190 4.1 36.3 1.0
C A:VAL179 4.2 36.6 1.0
CB A:TYR188 4.2 36.9 1.0
C A:TYR188 4.3 36.9 1.0
CA A:TYR181 4.4 37.1 1.0
C A:ILE180 4.4 38.0 1.0
CB A:VAL179 4.4 36.6 1.0
N A:EFZ602 4.4 20.0 1.0
C5 A:EFZ602 4.5 20.0 1.0
C1 A:EFZ602 4.5 20.0 1.0
N A:ILE180 4.6 38.0 1.0
CA A:GLY190 4.7 36.3 1.0
CA A:ILE180 4.7 38.0 1.0
C10 A:EFZ602 4.8 20.0 1.0
CG A:TYR181 4.8 37.1 1.0
CA A:TYR188 4.9 36.9 1.0
N A:VAL189 4.9 38.2 1.0
CA A:VAL179 5.0 36.6 1.0

Fluorine binding site 2 out of 3 in 7kjw

Go back to Fluorine Binding Sites List in 7kjw
Fluorine binding site 2 out of 3 in the Structure of Hiv-1 Reverse Transcriptase Initiation Complex Core with Efavirenz


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of Hiv-1 Reverse Transcriptase Initiation Complex Core with Efavirenz within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F602

b:20.0
occ:1.00
 F2 A:EFZ602 0.0 20.0 1.0
C13 A:EFZ602 1.4 20.0 1.0
F1 A:EFZ602 2.3 20.0 1.0
F3 A:EFZ602 2.3 20.0 1.0
C7 A:EFZ602 2.4 20.0 1.0
O2 A:EFZ602 2.8 20.0 1.0
C14 A:EFZ602 2.8 20.0 1.0
C6 A:EFZ602 2.8 20.0 1.0
N A:EFZ602 3.0 20.0 1.0
C1 A:EFZ602 3.1 20.0 1.0
CA A:GLY190 3.2 36.3 1.0
N A:GLY190 3.4 36.3 1.0
O1 A:EFZ602 3.4 20.0 1.0
C8 A:EFZ602 3.7 20.0 1.0
CG A:LYS103 3.8 33.7 1.0
C5 A:EFZ602 3.8 20.0 1.0
CG1 A:VAL179 3.8 36.6 1.0
O A:VAL179 3.9 36.6 1.0
CE A:LYS103 4.0 33.7 1.0
C A:GLY190 4.1 36.3 1.0
C2 A:EFZ602 4.2 20.0 1.0
CB A:VAL179 4.2 36.6 1.0
CD A:LYS103 4.3 33.7 1.0
O A:GLY190 4.5 36.3 1.0
C A:VAL189 4.6 38.2 1.0
CG2 A:VAL106 4.6 34.7 1.0
C A:VAL179 4.7 36.6 1.0
CG1 A:VAL106 4.7 34.7 1.0
C4 A:EFZ602 4.7 20.0 1.0
C9 A:EFZ602 4.8 20.0 1.0
CB A:LYS103 4.8 33.7 1.0
C3 A:EFZ602 4.9 20.0 1.0
O A:TYR188 5.0 36.9 1.0
N A:SER191 5.0 38.1 1.0

Fluorine binding site 3 out of 3 in 7kjw

Go back to Fluorine Binding Sites List in 7kjw
Fluorine binding site 3 out of 3 in the Structure of Hiv-1 Reverse Transcriptase Initiation Complex Core with Efavirenz


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of Hiv-1 Reverse Transcriptase Initiation Complex Core with Efavirenz within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F602

b:20.0
occ:1.00
 F3 A:EFZ602 0.0 20.0 1.0
C13 A:EFZ602 1.4 20.0 1.0
F1 A:EFZ602 2.3 20.0 1.0
F2 A:EFZ602 2.3 20.0 1.0
C7 A:EFZ602 2.4 20.0 1.0
C8 A:EFZ602 2.8 20.0 1.0
C6 A:EFZ602 2.9 20.0 1.0
C5 A:EFZ602 3.0 20.0 1.0
CB A:TYR188 3.3 36.9 1.0
C9 A:EFZ602 3.6 20.0 1.0
CG1 A:VAL106 3.6 34.7 1.0
N A:GLY190 3.6 36.3 1.0
O2 A:EFZ602 3.7 20.0 1.0
C A:TYR188 3.8 36.9 1.0
O A:TYR188 3.8 36.9 1.0
C1 A:EFZ602 3.9 20.0 1.0
CA A:GLY190 4.0 36.3 1.0
CA A:TYR188 4.1 36.9 1.0
N A:VAL189 4.1 38.2 1.0
C4 A:EFZ602 4.2 20.0 1.0
CD1 A:TYR188 4.2 36.9 1.0
CG A:TYR188 4.2 36.9 1.0
C A:VAL189 4.3 38.2 1.0
C14 A:EFZ602 4.3 20.0 1.0
N A:EFZ602 4.5 20.0 1.0
O A:VAL179 4.6 36.6 1.0
CA A:VAL189 4.6 38.2 1.0
CG2 A:VAL106 4.7 34.7 1.0
CB A:VAL106 4.8 34.7 1.0
C10 A:EFZ602 4.8 20.0 1.0
C2 A:EFZ602 4.8 20.0 1.0
C3 A:EFZ602 4.9 20.0 1.0
CB A:TYR181 5.0 37.1 1.0

Reference:

B.Ha, K.P.Larsen, J.Zhang, Z.Fu, E.Montabana, L.N.Jackson, D.H.Chen, E.V.Puglisi. High-Resolution View of Hiv-1 Reverse Transcriptase Initiation and Its Inhibition By Nnrti Drugs To Be Published.
Page generated: Fri Aug 2 08:21:06 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy