Fluorine in PDB 7kro: Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc

Enzymatic activity of Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc

All present enzymatic activity of Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc:
2.7.7.48; 3.6.4.12; 3.6.4.13;

Other elements in 7kro:

The structure of Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc also contains other interesting chemical elements:

Aluminium (Al) 2 atoms
Zinc (Zn) 8 atoms
Magnesium (Mg) 3 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc (pdb code 7kro). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc, PDB code: 7kro:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in 7kro

Go back to Fluorine Binding Sites List in 7kro
Fluorine binding site 1 out of 6 in the Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc within 5.0Å range:
probe atom residue distance (Å) B Occ
E:F706

b:71.1
occ:1.00
 F1 E:AF3706 0.0 71.1 1.0
AL E:AF3706 1.8 71.1 1.0
O3B E:ADP704 2.5 78.7 1.0
NH2 E:ARG567 2.6 68.8 1.0
O1B E:ADP704 2.9 78.7 1.0
F2 E:AF3706 3.1 71.1 1.0
F3 E:AF3706 3.1 71.1 1.0
PB E:ADP704 3.2 78.7 1.0
CZ E:ARG567 3.2 68.8 1.0
NE E:ARG567 3.5 68.8 1.0
NH1 E:ARG443 3.5 74.5 1.0
N E:GLY538 3.7 81.3 1.0
NH2 E:ARG443 3.8 74.5 1.0
MG E:MG705 4.0 54.6 1.0
CA E:GLY538 4.1 81.3 1.0
O3A E:ADP704 4.1 78.7 1.0
NH1 E:ARG567 4.1 68.8 1.0
CZ E:ARG443 4.2 74.5 1.0
N E:GLY285 4.3 75.2 1.0
C E:GLN537 4.4 79.3 1.0
OE1 E:GLN404 4.4 66.9 1.0
O2B E:ADP704 4.5 78.7 1.0
CA E:GLN537 4.6 79.3 1.0
CB E:PRO284 4.6 72.2 1.0
C E:GLY538 4.6 81.3 1.0
CD E:ARG567 4.7 68.8 1.0
O E:SER539 4.8 81.5 1.0
CA E:PRO284 4.8 72.2 1.0
O1A E:ADP704 5.0 78.7 1.0
C E:PRO284 5.0 72.2 1.0
CA E:GLY285 5.0 75.2 1.0

Fluorine binding site 2 out of 6 in 7kro

Go back to Fluorine Binding Sites List in 7kro
Fluorine binding site 2 out of 6 in the Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc within 5.0Å range:
probe atom residue distance (Å) B Occ
E:F706

b:71.1
occ:1.00
 F2 E:AF3706 0.0 71.1 1.0
AL E:AF3706 1.8 71.1 1.0
OE1 E:GLN404 2.2 66.9 1.0
O1B E:ADP704 3.1 78.7 1.0
F1 E:AF3706 3.1 71.1 1.0
F3 E:AF3706 3.1 71.1 1.0
CB E:PRO284 3.3 72.2 1.0
CA E:PRO284 3.3 72.2 1.0
CD E:GLN404 3.3 66.9 1.0
CE E:LYS288 4.0 61.5 1.0
PB E:ADP704 4.0 78.7 1.0
NZ E:LYS288 4.1 61.5 1.0
CG E:GLN404 4.1 66.9 1.0
O3B E:ADP704 4.2 78.7 1.0
N E:PRO284 4.2 72.2 1.0
NH2 E:ARG567 4.2 68.8 1.0
NE2 E:GLN404 4.2 66.9 1.0
N E:GLY285 4.3 75.2 1.0
C E:PRO284 4.3 72.2 1.0
CG E:PRO284 4.6 72.2 1.0
O2B E:ADP704 4.6 78.7 1.0
OE1 E:GLU375 4.6 62.0 1.0
CG E:GLN537 4.7 79.3 1.0
MG E:MG705 4.7 54.6 1.0
OE2 E:GLU375 4.7 62.0 1.0
CB E:ASP401 4.8 60.9 1.0
CD E:PRO284 4.8 72.2 1.0
C E:PRO283 4.9 73.4 1.0
CZ E:ARG567 4.9 68.8 1.0
O E:PRO283 4.9 73.4 1.0

Fluorine binding site 3 out of 6 in 7kro

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Fluorine binding site 3 out of 6 in the Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc within 5.0Å range:
probe atom residue distance (Å) B Occ
E:F706

b:71.1
occ:1.00
 F3 E:AF3706 0.0 71.1 1.0
AL E:AF3706 1.8 71.1 1.0
MG E:MG705 2.1 54.6 1.0
OE2 E:GLU375 2.3 62.0 1.0
O3B E:ADP704 2.5 78.7 1.0
PB E:ADP704 3.1 78.7 1.0
F2 E:AF3706 3.1 71.1 1.0
F1 E:AF3706 3.1 71.1 1.0
CD E:GLU375 3.1 62.0 1.0
O2B E:ADP704 3.3 78.7 1.0
O1B E:ADP704 3.5 78.7 1.0
OE1 E:GLU375 3.5 62.0 1.0
OG E:SER289 4.0 63.1 1.0
CA E:GLY538 4.0 81.3 1.0
N E:GLY538 4.2 81.3 1.0
CG E:GLU375 4.3 62.0 1.0
C E:GLN537 4.4 79.3 1.0
O E:GLN537 4.5 79.3 1.0
CE E:LYS288 4.5 61.5 1.0
O3A E:ADP704 4.6 78.7 1.0
OE1 E:GLN404 4.6 66.9 1.0
OD1 E:ASP374 4.7 58.1 1.0
CG E:GLN537 4.7 79.3 1.0

Fluorine binding site 4 out of 6 in 7kro

Go back to Fluorine Binding Sites List in 7kro
Fluorine binding site 4 out of 6 in the Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc within 5.0Å range:
probe atom residue distance (Å) B Occ
F:F1005

b:141.0
occ:1.00
 F1 F:AF31005 0.0 141.0 1.0
AL F:AF31005 1.8 141.0 1.0
O3B F:ADP1003 2.5 150.4 1.0
NH2 F:ARG567 2.6 150.1 1.0
O1B F:ADP1003 2.9 150.4 1.0
F2 F:AF31005 3.1 141.0 1.0
F3 F:AF31005 3.1 141.0 1.0
PB F:ADP1003 3.2 150.4 1.0
CZ F:ARG567 3.2 150.1 1.0
NE F:ARG567 3.5 150.1 1.0
NH1 F:ARG443 3.5 153.5 1.0
N F:GLY538 3.7 149.2 1.0
NH2 F:ARG443 3.8 153.5 1.0
MG F:MG1004 4.0 121.4 1.0
CA F:GLY538 4.1 149.2 1.0
O3A F:ADP1003 4.1 150.4 1.0
NH1 F:ARG567 4.1 150.1 1.0
CZ F:ARG443 4.2 153.5 1.0
N F:GLY285 4.3 147.7 1.0
C F:GLN537 4.4 143.0 1.0
OE1 F:GLN404 4.4 136.6 1.0
O2B F:ADP1003 4.5 150.4 1.0
CA F:GLN537 4.6 143.0 1.0
CB F:PRO284 4.6 143.5 1.0
C F:GLY538 4.7 149.2 1.0
CD F:ARG567 4.7 150.1 1.0
O F:SER539 4.8 152.7 1.0
CA F:PRO284 4.8 143.5 1.0
O2A F:ADP1003 5.0 150.4 1.0
C F:PRO284 5.0 143.5 1.0
CA F:GLY285 5.0 147.7 1.0

Fluorine binding site 5 out of 6 in 7kro

Go back to Fluorine Binding Sites List in 7kro
Fluorine binding site 5 out of 6 in the Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc within 5.0Å range:
probe atom residue distance (Å) B Occ
F:F1005

b:141.0
occ:1.00
 F2 F:AF31005 0.0 141.0 1.0
AL F:AF31005 1.8 141.0 1.0
OE1 F:GLN404 2.2 136.6 1.0
O1B F:ADP1003 3.0 150.4 1.0
F1 F:AF31005 3.1 141.0 1.0
F3 F:AF31005 3.1 141.0 1.0
CB F:PRO284 3.3 143.5 1.0
CA F:PRO284 3.3 143.5 1.0
CD F:GLN404 3.3 136.6 1.0
CE F:LYS288 4.0 140.3 1.0
PB F:ADP1003 4.0 150.4 1.0
NZ F:LYS288 4.1 140.3 1.0
CG F:GLN404 4.1 136.6 1.0
O3B F:ADP1003 4.2 150.4 1.0
N F:PRO284 4.2 143.5 1.0
NH2 F:ARG567 4.2 150.1 1.0
NE2 F:GLN404 4.2 136.6 1.0
N F:GLY285 4.3 147.7 1.0
C F:PRO284 4.3 143.5 1.0
CG F:PRO284 4.6 143.5 1.0
O2B F:ADP1003 4.6 150.4 1.0
OE1 F:GLU375 4.6 130.7 1.0
CG F:GLN537 4.7 143.0 1.0
MG F:MG1004 4.7 121.4 1.0
OE2 F:GLU375 4.7 130.7 1.0
CB F:ASP401 4.8 132.7 1.0
CD F:PRO284 4.8 143.5 1.0
C F:PRO283 4.9 142.5 1.0
CZ F:ARG567 4.9 150.1 1.0
O F:PRO283 4.9 142.5 1.0

Fluorine binding site 6 out of 6 in 7kro

Go back to Fluorine Binding Sites List in 7kro
Fluorine binding site 6 out of 6 in the Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Structure of Sars-Cov-2 Backtracked Complex Complex Bound to NSP13 Helicase - NSP13(2)-Btc within 5.0Å range:
probe atom residue distance (Å) B Occ
F:F1005

b:141.0
occ:1.00
 F3 F:AF31005 0.0 141.0 1.0
AL F:AF31005 1.8 141.0 1.0
MG F:MG1004 2.1 121.4 1.0
OE2 F:GLU375 2.3 130.7 1.0
O3B F:ADP1003 2.5 150.4 1.0
PB F:ADP1003 3.1 150.4 1.0
F2 F:AF31005 3.1 141.0 1.0
F1 F:AF31005 3.1 141.0 1.0
CD F:GLU375 3.1 130.7 1.0
O2B F:ADP1003 3.3 150.4 1.0
O1B F:ADP1003 3.5 150.4 1.0
OE1 F:GLU375 3.5 130.7 1.0
OG F:SER289 4.0 138.1 1.0
CA F:GLY538 4.0 149.2 1.0
N F:GLY538 4.2 149.2 1.0
CG F:GLU375 4.3 130.7 1.0
C F:GLN537 4.4 143.0 1.0
O F:GLN537 4.5 143.0 1.0
CE F:LYS288 4.5 140.3 1.0
O3A F:ADP1003 4.6 150.4 1.0
OE1 F:GLN404 4.6 136.6 1.0
OD1 F:ASP374 4.7 125.6 1.0
CG F:GLN537 4.7 143.0 1.0

Reference:

B.Malone, J.Chen, Q.Wang, E.C.Llewellyn, Y.J.Choi, P.D.B.Olinares, X.Cao, C.Hernandez, E.Eng, B.T.Chait, D.E.Shaw, R.Landick, S.A.Darst, E.A.Campbell. Structural Basis For Backtracking By the Sars-Cov-2 Replication-Transcription Complex Proc.Natl.Acad.Sci.Usa 2021.
ISSN: ESSN 1091-6490
Page generated: Fri Aug 2 08:29:38 2024

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