Fluorine in PDB 7m0z: Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766

Enzymatic activity of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766

All present enzymatic activity of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766:
2.7.11.1; 2.7.12.2;

Protein crystallography data

The structure of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766, PDB code: 7m0z was solved by K.Li, G.Gonzalez Del-Pino, B.H.Ha, E.Park, M.J.Eck, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 43.33 / 3.12
Space group P 31 2 1
Cell size a, b, c (Å), α, β, γ (°) 116.784, 116.784, 129.256, 90, 90, 120
R / Rfree (%) 19.1 / 22.5

Other elements in 7m0z:

The structure of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766 also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766 (pdb code 7m0z). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766, PDB code: 7m0z:

Fluorine binding site 1 out of 1 in 7m0z

Go back to Fluorine Binding Sites List in 7m0z
Fluorine binding site 1 out of 1 in the Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F402

b:82.0
occ:1.00
 F33 B:CHU402 0.0 82.0 1.0
C22 B:CHU402 1.3 77.7 1.0
C23 B:CHU402 2.3 82.8 1.0
C14 B:CHU402 2.4 74.1 1.0
N27 B:CHU402 2.7 91.4 1.0
C13 B:CHU402 2.8 70.5 1.0
CA B:ILE216 3.1 77.5 1.0
CB B:MET219 3.4 71.0 1.0
O B:ILE216 3.6 75.8 1.0
N24 B:CHU402 3.6 79.3 1.0
C26 B:CHU402 3.7 81.5 1.0
CB B:ILE216 3.7 74.9 1.0
CG2 B:ILE216 3.8 80.9 1.0
C B:ILE216 3.8 76.7 1.0
CG1 B:ILE216 3.8 72.3 1.0
O B:LEU215 3.8 75.3 1.0
CE B:MET219 3.9 74.5 1.0
N B:ILE216 4.0 77.3 1.0
C25 B:CHU402 4.1 77.3 1.0
CG B:MET219 4.1 88.0 1.0
C B:LEU215 4.2 73.9 1.0
C8 B:CHU402 4.3 74.3 1.0
S28 B:CHU402 4.3 87.1 1.0
CA B:MET219 4.7 76.7 1.0
C12 B:CHU402 4.7 76.6 1.0
O32 B:CHU402 4.7 74.8 1.0
SD B:MET219 4.9 96.3 1.0
N B:MET219 5.0 81.7 1.0

Reference:

K.Li, G.Gonzalez Del-Pino, B.H.Ha, E.Park, M.J.Eck. Crystal Structure of the Braf:MEK1 Kinases in Complex with Amppnp and CH5126766 To Be Published.
Page generated: Fri Aug 2 09:15:26 2024

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