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Fluorine in PDB 7m2f: CDK2 with Compound 14 Inhibitor with CarboxylateEnzymatic activity of CDK2 with Compound 14 Inhibitor with Carboxylate
All present enzymatic activity of CDK2 with Compound 14 Inhibitor with Carboxylate:
2.7.11.22; Protein crystallography data
The structure of CDK2 with Compound 14 Inhibitor with Carboxylate, PDB code: 7m2f
was solved by
K.L.Longenecker,
W.Qiu,
A.Korepanova,
Y.Tong,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the CDK2 with Compound 14 Inhibitor with Carboxylate
(pdb code 7m2f). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the CDK2 with Compound 14 Inhibitor with Carboxylate, PDB code: 7m2f: Fluorine binding site 1 out of 1 in 7m2fGo back to Fluorine Binding Sites List in 7m2f
Fluorine binding site 1 out
of 1 in the CDK2 with Compound 14 Inhibitor with Carboxylate
Mono view Stereo pair view
Reference:
Y.Tong,
A.S.Flojancic,
R.F.Clark,
C.Lai,
A.Mastracchio,
G.Zhu,
M.L.Smith,
P.J.Kovar,
B.Shaw,
D.H.Albert,
W.Qiu,
K.L.Longenecker,
X.Liu,
A.M.Olson,
D.J.Osterling,
S.K.Tahir,
D.C.Phillips,
J.D.Leverson,
A.J.Souers,
T.D.Penning.
Balancing Properties with Carboxylates: A Lead Optimization Campaign For Selective and Orally Active CDK9 Inhibitors Acs Med.Chem.Lett. 2021.
Page generated: Sat Jul 10 14:23:38 2021
ISSN: ISSN 1948-5875 DOI: 10.1021/ACSMEDCHEMLETT.1C00161 |
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