Fluorine in PDB 7mfh: Crystal Structure of Bio-32546 Bound Mouse Autotaxin
Enzymatic activity of Crystal Structure of Bio-32546 Bound Mouse Autotaxin
All present enzymatic activity of Crystal Structure of Bio-32546 Bound Mouse Autotaxin:
3.1.4.39;
3.1.4.39;
Protein crystallography data
The structure of Crystal Structure of Bio-32546 Bound Mouse Autotaxin, PDB code: 7mfh
was solved by
J.V.Chodaparambil,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 46.13 / 2.30 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 61.02, 61.62, 67.32, 89.07, 74.2, 79.88 |
| R / Rfree (%) | 21.5 / 26.8 |
Other elements in 7mfh:
The structure of Crystal Structure of Bio-32546 Bound Mouse Autotaxin also contains other interesting chemical elements:
| Iodine | (I) | 1 atom |
| Zinc | (Zn) | 7 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin
(pdb code 7mfh). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin, PDB code: 7mfh:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin, PDB code: 7mfh:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 7mfh
Go back to
Fluorine Binding Sites List in 7mfh
Fluorine binding site 1 out
of 6 in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Bio-32546 Bound Mouse Autotaxin within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 7mfh
Go back to
Fluorine Binding Sites List in 7mfh
Fluorine binding site 2 out
of 6 in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Bio-32546 Bound Mouse Autotaxin within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 7mfh
Go back to
Fluorine Binding Sites List in 7mfh
Fluorine binding site 3 out
of 6 in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Bio-32546 Bound Mouse Autotaxin within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 7mfh
Go back to
Fluorine Binding Sites List in 7mfh
Fluorine binding site 4 out
of 6 in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Bio-32546 Bound Mouse Autotaxin within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 7mfh
Go back to
Fluorine Binding Sites List in 7mfh
Fluorine binding site 5 out
of 6 in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of Bio-32546 Bound Mouse Autotaxin within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 7mfh
Go back to
Fluorine Binding Sites List in 7mfh
Fluorine binding site 6 out
of 6 in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of Bio-32546 Bound Mouse Autotaxin within 5.0Å range:
|
Reference:
B.Ma,
L.Zhang,
L.Sun,
Z.Xin,
G.Kumaravel,
D.Marcotte,
J.V.Chodaparambil,
Q.Wang,
A.Wehr,
J.Jing,
V.S.Hong,
T.Wang,
C.Huang,
Z.Shao,
S.Mi.
Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor Bio-32546. Acs Med.Chem.Lett. V. 12 1124 2021.
ISSN: ISSN 1948-5875
PubMed: 34267882
DOI: 10.1021/ACSMEDCHEMLETT.1C00211
Page generated: Fri Aug 2 09:29:02 2024
ISSN: ISSN 1948-5875
PubMed: 34267882
DOI: 10.1021/ACSMEDCHEMLETT.1C00211
Last articles
Zn in 9JPJZn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
