Fluorine in PDB 7mfh: Crystal Structure of Bio-32546 Bound Mouse Autotaxin
Enzymatic activity of Crystal Structure of Bio-32546 Bound Mouse Autotaxin
All present enzymatic activity of Crystal Structure of Bio-32546 Bound Mouse Autotaxin:
3.1.4.39;
3.1.4.39;
Protein crystallography data
The structure of Crystal Structure of Bio-32546 Bound Mouse Autotaxin, PDB code: 7mfh
was solved by
J.V.Chodaparambil,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 46.13 / 2.30 |
| Space group | P 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 61.02, 61.62, 67.32, 89.07, 74.2, 79.88 |
| R / Rfree (%) | 21.5 / 26.8 |
Other elements in 7mfh:
The structure of Crystal Structure of Bio-32546 Bound Mouse Autotaxin also contains other interesting chemical elements:
| Iodine | (I) | 1 atom |
| Zinc | (Zn) | 7 atoms |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin
(pdb code 7mfh). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin, PDB code: 7mfh:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
In total 6 binding sites of Fluorine where determined in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin, PDB code: 7mfh:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;
Fluorine binding site 1 out of 6 in 7mfh
Go back to
Fluorine Binding Sites List in 7mfh
Fluorine binding site 1 out
of 6 in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Bio-32546 Bound Mouse Autotaxin within 5.0Å range:
|
Fluorine binding site 2 out of 6 in 7mfh
Go back to
Fluorine Binding Sites List in 7mfh
Fluorine binding site 2 out
of 6 in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Bio-32546 Bound Mouse Autotaxin within 5.0Å range:
|
Fluorine binding site 3 out of 6 in 7mfh
Go back to
Fluorine Binding Sites List in 7mfh
Fluorine binding site 3 out
of 6 in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of Bio-32546 Bound Mouse Autotaxin within 5.0Å range:
|
Fluorine binding site 4 out of 6 in 7mfh
Go back to
Fluorine Binding Sites List in 7mfh
Fluorine binding site 4 out
of 6 in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of Bio-32546 Bound Mouse Autotaxin within 5.0Å range:
|
Fluorine binding site 5 out of 6 in 7mfh
Go back to
Fluorine Binding Sites List in 7mfh
Fluorine binding site 5 out
of 6 in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of Bio-32546 Bound Mouse Autotaxin within 5.0Å range:
|
Fluorine binding site 6 out of 6 in 7mfh
Go back to
Fluorine Binding Sites List in 7mfh
Fluorine binding site 6 out
of 6 in the Crystal Structure of Bio-32546 Bound Mouse Autotaxin
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of Bio-32546 Bound Mouse Autotaxin within 5.0Å range:
|
Reference:
B.Ma,
L.Zhang,
L.Sun,
Z.Xin,
G.Kumaravel,
D.Marcotte,
J.V.Chodaparambil,
Q.Wang,
A.Wehr,
J.Jing,
V.S.Hong,
T.Wang,
C.Huang,
Z.Shao,
S.Mi.
Discovery of Potent Selective Nonzinc Binding Autotaxin Inhibitor Bio-32546. Acs Med.Chem.Lett. V. 12 1124 2021.
ISSN: ISSN 1948-5875
PubMed: 34267882
DOI: 10.1021/ACSMEDCHEMLETT.1C00211
Page generated: Wed Apr 5 00:15:21 2023
ISSN: ISSN 1948-5875
PubMed: 34267882
DOI: 10.1021/ACSMEDCHEMLETT.1C00211
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