Fluorine in PDB 7mhd: Thioesterase Domain of Human Fatty Acid Synthase (Fasn-Te) Binding A Competitive Inhibitor Sbp-7635

Enzymatic activity of Thioesterase Domain of Human Fatty Acid Synthase (Fasn-Te) Binding A Competitive Inhibitor Sbp-7635

All present enzymatic activity of Thioesterase Domain of Human Fatty Acid Synthase (Fasn-Te) Binding A Competitive Inhibitor Sbp-7635:
3.1.2.14;

Protein crystallography data

The structure of Thioesterase Domain of Human Fatty Acid Synthase (Fasn-Te) Binding A Competitive Inhibitor Sbp-7635, PDB code: 7mhd was solved by A.E.Aleshin, L.Lambert, R.C.Liddington, N.Cosford, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 35.93 / 2.03
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 53.886, 61.486, 77.45, 90, 90, 90
R / Rfree (%) 19.3 / 24.6

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Thioesterase Domain of Human Fatty Acid Synthase (Fasn-Te) Binding A Competitive Inhibitor Sbp-7635 (pdb code 7mhd). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Thioesterase Domain of Human Fatty Acid Synthase (Fasn-Te) Binding A Competitive Inhibitor Sbp-7635, PDB code: 7mhd:

Fluorine binding site 1 out of 1 in 7mhd

Go back to Fluorine Binding Sites List in 7mhd
Fluorine binding site 1 out of 1 in the Thioesterase Domain of Human Fatty Acid Synthase (Fasn-Te) Binding A Competitive Inhibitor Sbp-7635


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Thioesterase Domain of Human Fatty Acid Synthase (Fasn-Te) Binding A Competitive Inhibitor Sbp-7635 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F601

b:52.1
occ:1.00
 F14 A:ZEP601 0.0 52.1 1.0
C13 A:ZEP601 1.4 48.4 1.0
C12 A:ZEP601 2.4 50.2 1.0
C15 A:ZEP601 2.4 45.5 1.0
C11 A:ZEP601 2.7 52.5 1.0
O A:ALA363 2.8 37.5 1.0
S09 A:ZEP601 3.2 55.3 1.0
C10 A:ZEP601 3.2 52.6 1.0
N A:ALA367 3.3 37.5 1.0
CB A:GLU366 3.4 46.1 1.0
C18 A:ZEP601 3.6 50.9 1.0
C A:ALA363 3.6 38.3 1.0
C16 A:ZEP601 3.7 47.7 1.0
CB A:ALA367 3.8 36.7 1.0
CA A:ALA363 3.8 36.8 1.0
CG A:GLU366 3.9 53.8 1.0
CA A:ALA367 3.9 36.4 1.0
C A:GLU366 4.0 37.1 1.0
C17 A:ZEP601 4.1 49.6 1.0
CA A:GLU366 4.2 41.4 1.0
CB A:ALA363 4.3 38.7 1.0
N19 A:ZEP601 4.4 56.0 1.0
CD1 A:LEU427 4.6 41.1 1.0
CD1 A:LEU355 4.7 68.0 1.0
C08 A:ZEP601 4.7 60.9 1.0
N A:GLU366 4.7 39.2 1.0
N A:GLU364 4.9 37.0 1.0
O A:GLU366 4.9 36.1 1.0

Reference:

A.E.Aleshin, L.Lambert, R.C.Liddington, N.Cosford. Thioesterase Domain of Human Fatty Acid Synthase (Fasn-Te) Binding A Competitive Inhibitor Sbp-7635 To Be Published.
Page generated: Wed Apr 5 00:15:11 2023

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