Fluorine in PDB 7ms6: Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (2-Fluoro-4-((4-Phenylpiperidin-1-Yl)Sulfonyl)Benzoyl)Glycine

Enzymatic activity of Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (2-Fluoro-4-((4-Phenylpiperidin-1-Yl)Sulfonyl)Benzoyl)Glycine

All present enzymatic activity of Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (2-Fluoro-4-((4-Phenylpiperidin-1-Yl)Sulfonyl)Benzoyl)Glycine:
3.4.19.12;

Protein crystallography data

The structure of Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (2-Fluoro-4-((4-Phenylpiperidin-1-Yl)Sulfonyl)Benzoyl)Glycine, PDB code: 7ms6 was solved by M.K.Mann, C.A.Zepeda-Velazquez, H.G.Alvarez, A.Dong, T.Kiyota, A.Aman, C.H.Arrowsmith, R.Al-Awar, R.J.Harding, M.Schapira, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 38.07 / 1.55
Space group P 43
Cell size a, b, c (Å), α, β, γ (°) 53.575, 53.575, 54.097, 90, 90, 90
R / Rfree (%) 14.8 / 16.4

Other elements in 7ms6:

The structure of Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (2-Fluoro-4-((4-Phenylpiperidin-1-Yl)Sulfonyl)Benzoyl)Glycine also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (2-Fluoro-4-((4-Phenylpiperidin-1-Yl)Sulfonyl)Benzoyl)Glycine (pdb code 7ms6). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (2-Fluoro-4-((4-Phenylpiperidin-1-Yl)Sulfonyl)Benzoyl)Glycine, PDB code: 7ms6:

Fluorine binding site 1 out of 1 in 7ms6

Go back to Fluorine Binding Sites List in 7ms6
Fluorine binding site 1 out of 1 in the Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (2-Fluoro-4-((4-Phenylpiperidin-1-Yl)Sulfonyl)Benzoyl)Glycine


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of USP5 Zinc-Finger Ubiquitin Binding Domain Co-Crystallized with (2-Fluoro-4-((4-Phenylpiperidin-1-Yl)Sulfonyl)Benzoyl)Glycine within 5.0Å range:
probe atom residue distance (Å) B Occ
A:F301

b:11.1
occ:1.00
 F A:ZPV301 0.0 11.1 1.0
C18 A:ZPV301 1.4 10.5 1.0
C19 A:ZPV301 2.3 12.1 1.0
C14 A:ZPV301 2.4 10.0 1.0
N1 A:ZPV301 2.7 8.2 1.0
C15 A:ZPV301 3.0 8.9 1.0
CH2 A:TRP209 3.1 8.4 1.0
CZ2 A:TRP209 3.2 7.9 1.0
O A:HOH535 3.2 21.9 1.0
O A:HOH428 3.3 11.9 1.0
C11 A:ZPV301 3.6 11.8 1.0
SD A:MET266 3.6 11.3 1.0
O A:HOH529 3.6 27.4 1.0
C13 A:ZPV301 3.6 10.8 1.0
C16 A:ZPV301 4.1 7.8 1.0
C12 A:ZPV301 4.1 11.0 1.0
O2 A:ZPV301 4.2 10.1 1.0
CZ3 A:TRP209 4.2 8.0 1.0
CE2 A:TRP209 4.3 7.9 1.0
O A:HOH445 4.4 23.4 1.0
OH A:TYR223 4.6 13.5 1.0
CE A:MET266 4.6 12.2 1.0
CD1 A:TYR259 4.6 8.7 1.0
O A:ZPV301 4.6 10.5 1.0
CB A:TYR259 4.6 8.7 1.0
CG A:TYR259 4.7 8.3 1.0
C17 A:ZPV301 5.0 9.3 1.0
CG A:MET266 5.0 12.3 1.0

Reference:

M.K.Mann, C.A.Zepeda-Velazquez, H.G.Alvarez, A.Dong, T.Kiyota, A.Aman, C.H.Arrowsmith, R.Al-Awar, R.J.Harding, M.Schapira. Structure Activity Relationship of Allosteric Inhibitors of USP5 To Be Published.
Page generated: Fri Aug 2 09:46:07 2024

Last articles

Zn in 9JPJ
Zn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy