Fluorine in PDB 7n33: Sars-Cov-2 NSP15 Endoribonuclease Pre-Cleavage State

The binding sites of Fluorine atom in the Sars-Cov-2 NSP15 Endoribonuclease Pre-Cleavage State (pdb code 7n33). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Sars-Cov-2 NSP15 Endoribonuclease Pre-Cleavage State, PDB code: 7n33:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Sars-Cov-2 NSP15 Endoribonuclease Pre-Cleavage State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Sars-Cov-2 NSP15 Endoribonuclease Pre-Cleavage State within 5.0Å range: probe atom residue distance (Å) B Occ G:F401 b:82.9 occ:1.00 F2' G:UFT401 0.0 82.9 1.0 C2' G:UFT401 1.4 82.9 1.0 C1' G:UFT401 2.4 82.9 1.0 NZ A:LYS290 2.4 70.8 1.0 C3' G:UFT401 2.5 82.9 1.0 OP2 G:A402 2.6 86.7 1.0 CE1 A:HIS250 2.8 80.7 1.0 P G:A402 2.8 86.7 1.0 O3' G:UFT401 2.9 82.9 1.0 OP1 G:A402 2.9 86.7 1.0 C4' G:UFT401 3.1 82.9 1.0 NE2 A:HIS250 3.1 80.7 1.0 CE A:LYS290 3.1 70.8 1.0 O4' G:UFT401 3.3 82.9 1.0 O2 G:UFT401 3.3 82.9 1.0 N1 G:UFT401 3.5 82.9 1.0 CD A:LYS290 3.5 70.8 1.0 C2 G:UFT401 3.8 82.9 1.0 ND1 A:HIS250 4.1 80.7 1.0 O5' G:A402 4.4 86.7 1.0 CD2 A:HIS250 4.5 80.7 1.0 N A:GLY248 4.5 83.6 1.0 O A:GLY248 4.6 83.6 1.0 O A:VAL292 4.6 65.0 1.0 C5' G:UFT401 4.6 82.9 1.0 C6 G:UFT401 4.7 82.9 1.0 CG A:LYS290 4.8 70.8 1.0 CA A:GLY248 4.9 83.6 1.0 CG A:HIS250 4.9 80.7 1.0 SG A:CYS293 4.9 69.0 1.0 CA A:CYS293 4.9 69.0 1.0

Fluorine binding site 2 out of 6 in the Sars-Cov-2 NSP15 Endoribonuclease Pre-Cleavage State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Sars-Cov-2 NSP15 Endoribonuclease Pre-Cleavage State within 5.0Å range: probe atom residue distance (Å) B Occ H:F401 b:84.6 occ:1.00 F2' H:UFT401 0.0 84.6 1.0 C2' H:UFT401 1.4 84.6 1.0 NZ B:LYS290 2.4 71.5 1.0 C1' H:UFT401 2.4 84.6 1.0 C3' H:UFT401 2.5 84.6 1.0 OP2 H:A402 2.6 87.7 1.0 CE1 B:HIS250 2.8 82.3 1.0 P H:A402 2.8 87.7 1.0 O3' H:UFT401 2.9 84.6 1.0 OP1 H:A402 2.9 87.7 1.0 C4' H:UFT401 3.1 84.6 1.0 CE B:LYS290 3.1 71.5 1.0 NE2 B:HIS250 3.1 82.3 1.0 O4' H:UFT401 3.3 84.6 1.0 O2 H:UFT401 3.3 84.6 1.0 N1 H:UFT401 3.5 84.6 1.0 CD B:LYS290 3.5 71.5 1.0 C2 H:UFT401 3.8 84.6 1.0 ND1 B:HIS250 4.1 82.3 1.0 O5' H:A402 4.4 87.7 1.0 CD2 B:HIS250 4.5 82.3 1.0 N B:GLY248 4.5 85.6 1.0 O B:VAL292 4.6 66.1 1.0 O B:GLY248 4.6 85.6 1.0 C5' H:UFT401 4.6 84.6 1.0 C6 H:UFT401 4.7 84.6 1.0 CG B:LYS290 4.8 71.5 1.0 CA B:GLY248 4.9 85.6 1.0 CG B:HIS250 5.0 82.3 1.0 SG B:CYS293 5.0 69.9 1.0 CA B:CYS293 5.0 69.9 1.0

Fluorine binding site 3 out of 6 in the Sars-Cov-2 NSP15 Endoribonuclease Pre-Cleavage State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Sars-Cov-2 NSP15 Endoribonuclease Pre-Cleavage State within 5.0Å range: probe atom residue distance (Å) B Occ I:F401 b:83.4 occ:1.00 F2' I:UFT401 0.0 83.4 1.0 C2' I:UFT401 1.4 83.4 1.0 NZ C:LYS290 2.3 70.7 1.0 C1' I:UFT401 2.4 83.4 1.0 C3' I:UFT401 2.5 83.4 1.0 OP2 I:A402 2.6 87.2 1.0 P I:A402 2.8 87.2 1.0 CE1 C:HIS250 2.9 80.7 1.0 O3' I:UFT401 2.9 83.4 1.0 OP1 I:A402 2.9 87.2 1.0 C4' I:UFT401 3.1 83.4 1.0 CE C:LYS290 3.1 70.7 1.0 NE2 C:HIS250 3.2 80.7 1.0 O4' I:UFT401 3.3 83.4 1.0 O2 I:UFT401 3.3 83.4 1.0 N1 I:UFT401 3.5 83.4 1.0 CD C:LYS290 3.5 70.7 1.0 C2 I:UFT401 3.8 83.4 1.0 ND1 C:HIS250 4.1 80.7 1.0 O5' I:A402 4.4 87.2 1.0 N C:GLY248 4.5 83.9 1.0 CD2 C:HIS250 4.5 80.7 1.0 O C:GLY248 4.6 83.9 1.0 C5' I:UFT401 4.6 83.4 1.0 O C:VAL292 4.6 65.2 1.0 C6 I:UFT401 4.7 83.4 1.0 CG C:LYS290 4.8 70.7 1.0 CA C:GLY248 4.9 83.9 1.0 CG C:HIS250 5.0 80.7 1.0 SG C:CYS293 5.0 69.5 1.0

Fluorine binding site 4 out of 6 in the Sars-Cov-2 NSP15 Endoribonuclease Pre-Cleavage State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Sars-Cov-2 NSP15 Endoribonuclease Pre-Cleavage State within 5.0Å range: probe atom residue distance (Å) B Occ J:F401 b:62.9 occ:1.00 F2' J:UFT401 0.0 62.9 1.0 C2' J:UFT401 1.4 62.9 1.0 C1' J:UFT401 2.4 62.9 1.0 C3' J:UFT401 2.5 62.9 1.0 NZ D:LYS290 2.6 45.8 1.0 OP2 J:A402 2.6 67.9 1.0 P J:A402 2.8 67.9 1.0 OP1 J:A402 2.9 67.9 1.0 O3' J:UFT401 2.9 62.9 1.0 C4' J:UFT401 3.1 62.9 1.0 O4' J:UFT401 3.3 62.9 1.0 O2 J:UFT401 3.3 62.9 1.0 CE1 D:HIS250 3.4 53.6 1.0 NE2 D:HIS250 3.5 53.6 1.0 CE D:LYS290 3.5 45.8 1.0 N1 J:UFT401 3.5 62.9 1.0 CD D:LYS290 3.7 45.8 1.0 C2 J:UFT401 3.8 62.9 1.0 O5' J:A402 4.4 67.9 1.0 C5' J:UFT401 4.6 62.9 1.0 N D:GLY248 4.6 57.5 1.0 ND1 D:HIS250 4.7 53.6 1.0 C6 J:UFT401 4.7 62.9 1.0 CD2 D:HIS250 4.8 53.6 1.0 O D:VAL292 4.9 44.9 1.0 O D:LEU246 5.0 50.1 1.0

Fluorine binding site 5 out of 6 in the Sars-Cov-2 NSP15 Endoribonuclease Pre-Cleavage State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Sars-Cov-2 NSP15 Endoribonuclease Pre-Cleavage State within 5.0Å range: probe atom residue distance (Å) B Occ K:F401 b:64.5 occ:1.00 F2' K:UFT401 0.0 64.5 1.0 C2' K:UFT401 1.4 64.5 1.0 C1' K:UFT401 2.4 64.5 1.0 C3' K:UFT401 2.5 64.5 1.0 OP2 K:A402 2.6 69.8 1.0 NZ E:LYS290 2.7 46.5 1.0 P K:A402 2.8 69.8 1.0 O3' K:UFT401 2.9 64.5 1.0 OP1 K:A402 2.9 69.8 1.0 C4' K:UFT401 3.1 64.5 1.0 O4' K:UFT401 3.3 64.5 1.0 O2 K:UFT401 3.3 64.5 1.0 N1 K:UFT401 3.5 64.5 1.0 CE1 E:HIS250 3.6 53.8 1.0 CE E:LYS290 3.6 46.5 1.0 NE2 E:HIS250 3.6 53.8 1.0 CD E:LYS290 3.7 46.5 1.0 C2 K:UFT401 3.8 64.5 1.0 O5' K:A402 4.4 69.8 1.0 C5' K:UFT401 4.6 64.5 1.0 N E:GLY248 4.7 57.8 1.0 C6 K:UFT401 4.7 64.5 1.0 ND1 E:HIS250 4.9 53.8 1.0 O E:LEU246 5.0 51.0 1.0

Fluorine binding site 6 out of 6 in the Sars-Cov-2 NSP15 Endoribonuclease Pre-Cleavage State


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Sars-Cov-2 NSP15 Endoribonuclease Pre-Cleavage State within 5.0Å range: probe atom residue distance (Å) B Occ L:F401 b:63.7 occ:1.00 F2' L:UFT401 0.0 63.7 1.0 C2' L:UFT401 1.4 63.7 1.0 C1' L:UFT401 2.4 63.7 1.0 C3' L:UFT401 2.5 63.7 1.0 OP2 L:A402 2.6 68.5 1.0 NZ F:LYS290 2.7 46.0 1.0 P L:A402 2.8 68.5 1.0 OP1 L:A402 2.9 68.5 1.0 O3' L:UFT401 2.9 63.7 1.0 C4' L:UFT401 3.1 63.7 1.0 O4' L:UFT401 3.3 63.7 1.0 O2 L:UFT401 3.3 63.7 1.0 N1 L:UFT401 3.5 63.7 1.0 CE1 F:HIS250 3.6 52.3 1.0 CE F:LYS290 3.6 46.0 1.0 NE2 F:HIS250 3.7 52.3 1.0 CD F:LYS290 3.7 46.0 1.0 C2 L:UFT401 3.8 63.7 1.0 O5' L:A402 4.4 68.5 1.0 C5' L:UFT401 4.6 63.7 1.0 N F:GLY248 4.7 57.5 1.0 C6 L:UFT401 4.7 63.7 1.0 ND1 F:HIS250 4.9 52.3 1.0 O F:LEU246 5.0 51.5 1.0

M.N.Frazier, L.B.Dillard, J.M.Krahn, L.Perera, J.G.Williams, I.M.Wilson, Z.D.Stewart, M.C.Pillon, L.J.Deterding, M.J.Borgnia, R.E.Stanley. Characterization of SARS2 NSP15 Nuclease Activity Reveals Its Mad About U To Be Published.