Fluorine in PDB 7niq: Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class)

Enzymatic activity of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class)

All present enzymatic activity of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class):
3.6.4.13;

Other elements in 7niq:

The structure of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class) also contains other interesting chemical elements:

Aluminium (Al) 1 atom
Zinc (Zn) 1 atom

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class) (pdb code 7niq). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class), PDB code: 7niq:
Jump to Fluorine binding site number: 1; 2; 3; 4;

Fluorine binding site 1 out of 4 in 7niq

Go back to Fluorine Binding Sites List in 7niq
Fluorine binding site 1 out of 4 in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1102

b:80.7
occ:1.00
 F1 B:ALF1102 0.0 80.7 1.0
AL B:ALF1102 1.8 80.7 1.0
F4 B:ALF1102 2.5 80.7 1.0
F3 B:ALF1102 2.5 80.7 1.0
O3B B:ADP1101 2.8 84.9 1.0
O2B B:ADP1101 3.4 84.9 1.0
OE2 B:GLU445 3.4 50.3 1.0
F2 B:ALF1102 3.6 80.7 1.0
PB B:ADP1101 3.7 84.9 1.0
CA B:GLY795 3.9 84.6 1.0
N B:GLY795 4.3 84.6 1.0
O3A B:ADP1101 4.6 84.9 1.0
CD B:GLU445 4.6 50.3 1.0
O1B B:ADP1101 4.9 84.9 1.0
C B:GLY795 4.9 84.6 1.0

Fluorine binding site 2 out of 4 in 7niq

Go back to Fluorine Binding Sites List in 7niq
Fluorine binding site 2 out of 4 in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1102

b:80.7
occ:1.00
 F2 B:ALF1102 0.0 80.7 1.0
AL B:ALF1102 1.8 80.7 1.0
F3 B:ALF1102 2.5 80.7 1.0
NZ B:LYS336 2.5 74.7 1.0
F4 B:ALF1102 2.5 80.7 1.0
O2B B:ADP1101 2.6 84.9 1.0
PB B:ADP1101 2.9 84.9 1.0
O1B B:ADP1101 2.9 84.9 1.0
CE B:LYS336 3.1 74.7 1.0
O3B B:ADP1101 3.2 84.9 1.0
CD B:LYS336 3.3 74.7 1.0
CA B:THR332 3.4 80.9 1.0
F1 B:ALF1102 3.6 80.7 1.0
CG2 B:THR332 3.8 80.9 1.0
CB B:THR332 3.9 80.9 1.0
CB B:ALA490 4.1 70.3 1.0
N B:THR332 4.2 80.9 1.0
N B:GLY333 4.2 86.8 1.0
O B:PRO331 4.3 77.9 1.0
C B:THR332 4.3 80.9 1.0
CG B:LYS336 4.4 74.7 1.0
O3A B:ADP1101 4.4 84.9 1.0
C B:PRO331 4.5 77.9 1.0
O B:LEU330 4.7 72.6 1.0
N B:ALA490 4.9 70.3 1.0
CA B:ALA490 4.9 70.3 1.0

Fluorine binding site 3 out of 4 in 7niq

Go back to Fluorine Binding Sites List in 7niq
Fluorine binding site 3 out of 4 in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1102

b:80.7
occ:1.00
 F3 B:ALF1102 0.0 80.7 1.0
AL B:ALF1102 1.8 80.7 1.0
O2B B:ADP1101 2.2 84.9 1.0
F2 B:ALF1102 2.5 80.7 1.0
F1 B:ALF1102 2.5 80.7 1.0
PB B:ADP1101 3.3 84.9 1.0
CG2 B:THR332 3.3 80.9 1.0
CB B:THR332 3.5 80.9 1.0
F4 B:ALF1102 3.6 80.7 1.0
O3B B:ADP1101 3.6 84.9 1.0
CA B:THR332 3.9 80.9 1.0
O1B B:ADP1101 4.3 84.9 1.0
N B:GLY333 4.3 86.8 1.0
O3A B:ADP1101 4.4 84.9 1.0
OE1 B:GLN818 4.5 81.3 1.0
C B:THR332 4.7 80.9 1.0
OG1 B:THR332 4.8 80.9 1.0
NZ B:LYS336 4.9 74.7 1.0
OE2 B:GLU445 5.0 50.3 1.0

Fluorine binding site 4 out of 4 in 7niq

Go back to Fluorine Binding Sites List in 7niq
Fluorine binding site 4 out of 4 in the Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryoem Structure of Disease Related M854K MDA5-Dsrna Filament in Complex with Adp-ALF4(Major Class) within 5.0Å range:
probe atom residue distance (Å) B Occ
B:F1102

b:80.7
occ:1.00
 F4 B:ALF1102 0.0 80.7 1.0
AL B:ALF1102 1.8 80.7 1.0
O3B B:ADP1101 2.3 84.9 1.0
F1 B:ALF1102 2.5 80.7 1.0
F2 B:ALF1102 2.5 80.7 1.0
PB B:ADP1101 3.2 84.9 1.0
CD B:LYS336 3.4 74.7 1.0
F3 B:ALF1102 3.6 80.7 1.0
OE2 B:GLU445 3.6 50.3 1.0
O2B B:ADP1101 3.7 84.9 1.0
O1B B:ADP1101 3.7 84.9 1.0
NZ B:LYS336 4.0 74.7 1.0
CE B:LYS336 4.2 74.7 1.0
CB B:LYS336 4.4 74.7 1.0
CG B:LYS336 4.4 74.7 1.0
O3A B:ADP1101 4.6 84.9 1.0
CD B:GLU445 4.7 50.3 1.0

Reference:

Q.Yu, A.Herrero Del Valle, R.Singh, Y.Modis. MDA5 Autoimmune Disease Variant M854K Prevents Atp-Dependent Structural Discrimination of Viral and Cellular Rna. Nat Commun 2021.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-021-27062-5
Page generated: Fri Aug 2 10:05:44 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy