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Fluorine in PDB 7nzn: Structure of Ret Kinase Domain Bound to Inhibitor Jb-48Enzymatic activity of Structure of Ret Kinase Domain Bound to Inhibitor Jb-48
All present enzymatic activity of Structure of Ret Kinase Domain Bound to Inhibitor Jb-48:
2.7.10.1; Protein crystallography data
The structure of Structure of Ret Kinase Domain Bound to Inhibitor Jb-48, PDB code: 7nzn
was solved by
D.C.Briggs,
N.Q.Mcdonald,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Ret Kinase Domain Bound to Inhibitor Jb-48
(pdb code 7nzn). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Structure of Ret Kinase Domain Bound to Inhibitor Jb-48, PDB code: 7nzn: Fluorine binding site 1 out of 1 in 7nznGo back to Fluorine Binding Sites List in 7nzn
Fluorine binding site 1 out
of 1 in the Structure of Ret Kinase Domain Bound to Inhibitor Jb-48
Mono view Stereo pair view
Reference:
L.Zhang,
M.Moccia,
D.C.Briggs,
J.B.Bharate,
N.R.Lakkaniga,
P.Knowles,
W.Yan,
P.Tran,
A.Kharbanda,
X.Wang,
Y.K.Leung,
B.Frett,
M.Santoro,
N.Q.Mcdonald,
F.Carlomagno,
H.Y.Li.
Discovery of N-Trisubstituted Pyrimidine Derivatives As Type I Ret and Ret Gatekeeper Mutant Inhibitors with A Novel Kinase Binding Pose. J.Med.Chem. V. 65 1536 2022.
Page generated: Fri Aug 2 10:24:36 2024
ISSN: ISSN 0022-2623 PubMed: 35081714 DOI: 10.1021/ACS.JMEDCHEM.1C01280 |
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