Fluorine in PDB 7oug: Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir

The structure of Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir also contains other interesting chemical elements:

Magnesium	(Mg)	4 atoms
Zinc	(Zn)	4 atoms

The binding sites of Fluorine atom in the Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir (pdb code 7oug). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir, PDB code: 7oug:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir within 5.0Å range: probe atom residue distance (Å) B Occ E:F304 b:9.9 occ:1.00 FAI E:RLT304 0.0 9.9 1.0 CAX E:RLT304 1.3 9.9 1.0 CAK E:RLT304 2.4 9.9 1.0 CAJ E:RLT304 2.4 9.9 1.0 N1 I:DG4 2.9 9.9 1.0 C6 I:DG4 3.1 9.9 1.0 CG2 E:THR152 3.3 25.3 1.0 O6 I:DG4 3.4 9.9 1.0 C2 I:DG4 3.4 9.9 1.0 CAM E:RLT304 3.6 9.9 1.0 CAL E:RLT304 3.6 9.9 1.0 C5 I:DG4 3.6 9.9 1.0 N3 J:DC19 3.8 9.9 1.0 N4 J:DC19 3.9 9.9 1.0 C4 J:DC19 3.9 9.9 1.0 C4 I:DG4 4.0 9.9 1.0 N3 I:DG4 4.0 9.9 1.0 N2 I:DG4 4.0 9.9 1.0 CAY E:RLT304 4.1 9.9 1.0 CA E:THR152 4.2 25.3 1.0 CB E:THR152 4.3 25.3 1.0 N E:THR152 4.4 25.3 1.0 C2 J:DC19 4.5 9.9 1.0 N7 I:DG4 4.5 9.9 1.0 C5 J:DC19 4.7 9.9 1.0 C E:PRO151 4.8 152.4 1.0 O E:PRO151 4.9 152.4 1.0 O2 J:DC19 5.0 9.9 1.0 N9 I:DG4 5.0 9.9 1.0

Fluorine binding site 2 out of 2 in the Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Stlv-1 Intasome:B56 in Complex with the Strand-Transfer Inhibitor Raltegravir within 5.0Å range: probe atom residue distance (Å) B Occ B:F304 b:9.9 occ:1.00 FAI B:RLT304 0.0 9.9 1.0 CAX B:RLT304 1.3 9.9 1.0 CAK B:RLT304 2.4 9.9 1.0 CAJ B:RLT304 2.4 9.9 1.0 N1 K:DG4 2.9 9.9 1.0 C6 K:DG4 3.0 9.9 1.0 CG2 B:THR152 3.3 9.9 1.0 O6 K:DG4 3.3 9.9 1.0 C2 K:DG4 3.4 9.9 1.0 CAM B:RLT304 3.6 9.9 1.0 C5 K:DG4 3.6 9.9 1.0 CAL B:RLT304 3.6 9.9 1.0 N3 L:DC19 3.8 9.9 1.0 N4 L:DC19 3.8 9.9 1.0 C4 L:DC19 3.9 9.9 1.0 C4 K:DG4 4.0 9.9 1.0 N3 K:DG4 4.0 9.9 1.0 N2 K:DG4 4.0 9.9 1.0 CAY B:RLT304 4.1 9.9 1.0 CA B:THR152 4.3 9.9 1.0 CB B:THR152 4.3 9.9 1.0 C2 L:DC19 4.5 9.9 1.0 N B:THR152 4.5 9.9 1.0 N7 K:DG4 4.5 9.9 1.0 C5 L:DC19 4.7 9.9 1.0 C B:PRO151 4.9 11.7 1.0 O2 L:DC19 4.9 9.9 1.0 O B:PRO151 5.0 11.7 1.0

M.S.Barski, T.Vanzo, X.Zhao, S.J.Smith, A.Ballandras-Colas, N.B.Cronin, V.E.Pye, S.H.Hughes, T.R.Burke, P.Cherepanov, G.N.Maertens. Structural Basis For the Inhibition of Htlv-1 Integration Inferred From Cryo-Em Deltaretroviral Intasome Structures Nat Commun 2021.
ISSN: ESSN 2041-1723