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Fluorine in PDB 7p5k: Pyrazole Carboxylic Acid Inhibitors of KEAP1:NRF2 InteractionProtein crystallography data
The structure of Pyrazole Carboxylic Acid Inhibitors of KEAP1:NRF2 Interaction, PDB code: 7p5k
was solved by
T.G.Davies,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7p5k:
The structure of Pyrazole Carboxylic Acid Inhibitors of KEAP1:NRF2 Interaction also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Pyrazole Carboxylic Acid Inhibitors of KEAP1:NRF2 Interaction
(pdb code 7p5k). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Pyrazole Carboxylic Acid Inhibitors of KEAP1:NRF2 Interaction, PDB code: 7p5k: Fluorine binding site 1 out of 1 in 7p5kGo back to Fluorine Binding Sites List in 7p5k
Fluorine binding site 1 out
of 1 in the Pyrazole Carboxylic Acid Inhibitors of KEAP1:NRF2 Interaction
Mono view Stereo pair view
Reference:
D.Norton,
W.G.Bonnette,
J.F.Callahan,
M.G.Carr,
C.M.Griffiths-Jones,
T.D.Heightman,
J.K.Kerns,
H.Nie,
S.J.Rich,
C.Richardson,
W.Rumsey,
Y.Sanchez,
M.L.Verdonk,
H.M.G.Willems,
W.E.Wixted,
L.Wolfe 3Rd,
A.J.Woolford,
Z.Wu,
T.G.Davies.
Fragment-Guided Discovery of Pyrazole Carboxylic Acid Inhibitors of the Kelch-Like Ech-Associated Protein 1: Nuclear Factor Erythroid 2 Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction. J.Med.Chem. 2021.
Page generated: Fri Aug 2 10:56:56 2024
ISSN: ISSN 0022-2623 PubMed: 34705450 DOI: 10.1021/ACS.JMEDCHEM.1C01351 |
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