|
Fluorine in PDB 7q7w: JAK2 in Complex with 4-(2-{[5-(Dimethylamino)Pentyl]Amino}-8-{[(2S)-1- Hydroxypropan-2-Yl]Amino}Quinazolin-6-Yl)-5-Ethyl-2-FluorophenolEnzymatic activity of JAK2 in Complex with 4-(2-{[5-(Dimethylamino)Pentyl]Amino}-8-{[(2S)-1- Hydroxypropan-2-Yl]Amino}Quinazolin-6-Yl)-5-Ethyl-2-Fluorophenol
All present enzymatic activity of JAK2 in Complex with 4-(2-{[5-(Dimethylamino)Pentyl]Amino}-8-{[(2S)-1- Hydroxypropan-2-Yl]Amino}Quinazolin-6-Yl)-5-Ethyl-2-Fluorophenol:
2.7.10.2; Protein crystallography data
The structure of JAK2 in Complex with 4-(2-{[5-(Dimethylamino)Pentyl]Amino}-8-{[(2S)-1- Hydroxypropan-2-Yl]Amino}Quinazolin-6-Yl)-5-Ethyl-2-Fluorophenol, PDB code: 7q7w
was solved by
P.Rowland,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the JAK2 in Complex with 4-(2-{[5-(Dimethylamino)Pentyl]Amino}-8-{[(2S)-1- Hydroxypropan-2-Yl]Amino}Quinazolin-6-Yl)-5-Ethyl-2-Fluorophenol
(pdb code 7q7w). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the JAK2 in Complex with 4-(2-{[5-(Dimethylamino)Pentyl]Amino}-8-{[(2S)-1- Hydroxypropan-2-Yl]Amino}Quinazolin-6-Yl)-5-Ethyl-2-Fluorophenol, PDB code: 7q7w: Fluorine binding site 1 out of 1 in 7q7wGo back to Fluorine Binding Sites List in 7q7w
Fluorine binding site 1 out
of 1 in the JAK2 in Complex with 4-(2-{[5-(Dimethylamino)Pentyl]Amino}-8-{[(2S)-1- Hydroxypropan-2-Yl]Amino}Quinazolin-6-Yl)-5-Ethyl-2-Fluorophenol
Mono view Stereo pair view
Reference:
C.R.Wellaway,
I.R.Baldwin,
P.Bamborough,
D.Barker,
M.A.Bartholomew,
C.W.Chung,
B.Dumpelfeld,
J.P.Evans,
N.J.Fazakerley,
P.Homes,
S.P.Keeling,
X.Q.Lewell,
F.W.Mcnab,
J.Morley,
D.Needham,
M.Neu,
A.J.M.Van Oosterhout,
A.Pal,
F.B.M.Reinhard,
F.Rianjongdee,
C.M.Robertson,
P.Rowland,
R.R.Shah,
E.B.Sherriff,
L.A.Sloan,
S.Teague,
D.A.Thomas,
N.Wellaway,
J.Wojno-Picon,
J.M.Woolven,
D.M.Coe.
Investigation of Janus Kinase (Jak) Inhibitors For Lung Delivery and the Importance of Aldehyde Oxidase Metabolism. J.Med.Chem. V. 65 633 2022.
Page generated: Wed Apr 5 00:38:12 2023
ISSN: ISSN 0022-2623 PubMed: 34928601 DOI: 10.1021/ACS.JMEDCHEM.1C01765 |
Last articlesZn in 8WB0Zn in 8WAX Zn in 8WAU Zn in 8WAZ Zn in 8WAY Zn in 8WAV Zn in 8WAW Zn in 8WAT Zn in 8W7M Zn in 8WD3 |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |