Fluorine in PDB 7rbt: Cryo-Em Structure of Human Gastric Inhibitory Polypeptide Receptor Gipr Bound to Tirzepatide

The binding sites of Fluorine atom in the Cryo-Em Structure of Human Gastric Inhibitory Polypeptide Receptor Gipr Bound to Tirzepatide (pdb code 7rbt). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Cryo-Em Structure of Human Gastric Inhibitory Polypeptide Receptor Gipr Bound to Tirzepatide, PDB code: 7rbt:

Fluorine binding site 1 out of 1 in the Cryo-Em Structure of Human Gastric Inhibitory Polypeptide Receptor Gipr Bound to Tirzepatide


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Human Gastric Inhibitory Polypeptide Receptor Gipr Bound to Tirzepatide within 5.0Å range: probe atom residue distance (Å) B Occ R:F501 b:44.9 occ:1.00 F28 R:41Y501 0.0 44.9 1.0 C27 R:41Y501 1.4 44.9 1.0 C26 R:41Y501 2.4 44.9 1.0 C29 R:41Y501 2.4 44.9 1.0 NE2 R:HIS353 2.8 42.6 1.0 O30 R:41Y501 2.8 44.9 1.0 CD2 R:HIS353 3.0 42.6 1.0 CE1 R:HIS353 3.2 42.6 1.0 CG R:GLN384 3.4 45.9 1.0 CG R:HIS353 3.5 42.6 1.0 ND1 R:HIS353 3.6 42.6 1.0 C25 R:41Y501 3.6 44.9 1.0 CB R:GLN384 3.7 45.9 1.0 C31 R:41Y501 3.7 44.9 1.0 CD R:GLN384 3.8 45.9 1.0 CA R:GLN384 4.0 45.9 1.0 CB R:PRO348 4.1 34.4 1.0 C37 R:41Y501 4.2 44.9 1.0 CA R:PRO348 4.2 34.4 1.0 OE1 R:GLN384 4.2 45.9 1.0 NE2 R:GLN384 4.3 45.9 1.0 O R:LEU380 4.4 50.4 1.0 CB R:LEU380 4.4 50.4 1.0 CB R:HIS353 4.6 42.6 1.0 C R:LEU380 4.6 50.4 1.0 N R:GLN384 4.6 45.9 1.0 CA R:LEU380 4.6 50.4 1.0 C24 R:41Y501 4.7 44.9 1.0 N32 R:41Y501 4.9 44.9 1.0 N R:PRO348 4.9 34.4 1.0 CD2 R:LEU387 5.0 54.0 1.0 CD2 R:LEU380 5.0 50.4 1.0

B.Sun, F.S.Willard, D.Feng, J.Alsina-Fernandez, Q.Chen, M.Vieth, J.D.Ho, A.D.Showalter, C.Stutsman, L.Ding, T.M.Suter, J.D.Dunbar, J.W.Carpenter, F.A.Mohammed, E.Aihara, R.A.Brown, A.B.Bueno, P.J.Emmerson, J.S.Moyers, T.S.Kobilka, M.P.Coghlan, B.K.Kobilka, K.W.Sloop. Structural Determinants of Dual Incretin Receptor Agonism By Tirzepatide. Proc.Natl.Acad.Sci.Usa V. 119 06119 2022.
ISSN: ESSN 1091-6490
PubMed: 35333651
DOI: 10.1073/PNAS.2116506119