Fluorine in PDB 7re2: Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(1)-Rtc

Enzymatic activity of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(1)-Rtc

All present enzymatic activity of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(1)-Rtc:
2.7.7.48; 3.6.4.12; 3.6.4.13;

Other elements in 7re2:

The structure of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(1)-Rtc also contains other interesting chemical elements:

Zinc (Zn) 5 atoms
Aluminium (Al) 1 atom
Magnesium (Mg) 2 atoms

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(1)-Rtc (pdb code 7re2). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(1)-Rtc, PDB code: 7re2:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in 7re2

Go back to Fluorine Binding Sites List in 7re2
Fluorine binding site 1 out of 3 in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(1)-Rtc


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(1)-Rtc within 5.0Å range:
probe atom residue distance (Å) B Occ
E:F706

b:121.1
occ:1.00
 F1 E:AF3706 0.0 121.1 1.0
AL E:AF3706 1.8 121.1 1.0
NH2 E:ARG443 2.2 126.7 1.0
O3B E:ADP704 2.8 120.7 1.0
NH2 E:ARG567 2.8 126.2 1.0
F3 E:AF3706 3.1 121.1 1.0
F2 E:AF3706 3.1 121.1 1.0
CZ E:ARG443 3.1 126.7 1.0
NH1 E:ARG443 3.4 126.7 1.0
CA E:GLY538 3.6 127.4 1.0
O1B E:ADP704 3.6 120.7 1.0
CZ E:ARG567 3.6 126.2 1.0
PB E:ADP704 3.7 120.7 1.0
N E:GLY538 3.8 127.4 1.0
NE E:ARG567 4.1 126.2 1.0
C E:GLY538 4.1 127.4 1.0
MG E:MG705 4.1 99.1 1.0
NE E:ARG443 4.3 126.7 1.0
O3A E:ADP704 4.3 120.7 1.0
O1A E:ADP704 4.3 120.7 1.0
O E:GLY538 4.4 127.4 1.0
N E:GLY285 4.4 118.9 1.0
NH1 E:ARG567 4.4 126.2 1.0
NE2 E:GLN537 4.4 123.7 1.0
CB E:PRO284 4.5 118.8 1.0
CA E:PRO284 4.6 118.8 1.0
OE2 E:GLU375 4.7 110.4 1.0
N E:SER539 4.8 127.9 1.0
NZ E:LYS288 5.0 111.8 1.0

Fluorine binding site 2 out of 3 in 7re2

Go back to Fluorine Binding Sites List in 7re2
Fluorine binding site 2 out of 3 in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(1)-Rtc


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(1)-Rtc within 5.0Å range:
probe atom residue distance (Å) B Occ
E:F706

b:121.1
occ:1.00
 F2 E:AF3706 0.0 121.1 1.0
AL E:AF3706 1.8 121.1 1.0
NE2 E:GLN404 2.5 114.8 1.0
NE2 E:GLN537 3.0 123.7 1.0
F1 E:AF3706 3.1 121.1 1.0
F3 E:AF3706 3.1 121.1 1.0
CD E:GLN404 3.3 114.8 1.0
CB E:PRO284 3.5 118.8 1.0
CA E:PRO284 3.6 118.8 1.0
CG E:GLN404 3.7 114.8 1.0
NZ E:LYS288 3.9 111.8 1.0
OE2 E:GLU375 4.0 110.4 1.0
NH2 E:ARG567 4.1 126.2 1.0
O1B E:ADP704 4.2 120.7 1.0
OE1 E:GLU375 4.2 110.4 1.0
CD E:GLN537 4.2 123.7 1.0
OE1 E:GLN404 4.2 114.8 1.0
N E:PRO284 4.3 118.8 1.0
CE E:LYS288 4.3 111.8 1.0
CG E:PRO284 4.5 118.8 1.0
CD E:GLU375 4.5 110.4 1.0
O3B E:ADP704 4.5 120.7 1.0
CD E:PRO284 4.5 118.8 1.0
NH1 E:ARG567 4.8 126.2 1.0
CZ E:ARG567 4.8 126.2 1.0
C E:PRO284 4.8 118.8 1.0
PB E:ADP704 4.9 120.7 1.0
NH2 E:ARG443 4.9 126.7 1.0
N E:GLY285 4.9 118.9 1.0
OE1 E:GLN537 4.9 123.7 1.0

Fluorine binding site 3 out of 3 in 7re2

Go back to Fluorine Binding Sites List in 7re2
Fluorine binding site 3 out of 3 in the Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(1)-Rtc


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Sars-Cov-2 Replication-Transcription Complex Bound to NSP13 Helicase - NSP13(1)-Rtc within 5.0Å range:
probe atom residue distance (Å) B Occ
E:F706

b:121.1
occ:1.00
 F3 E:AF3706 0.0 121.1 1.0
AL E:AF3706 1.8 121.1 1.0
OE2 E:GLU375 2.2 110.4 1.0
O3B E:ADP704 2.3 120.7 1.0
F1 E:AF3706 3.1 121.1 1.0
F2 E:AF3706 3.1 121.1 1.0
PB E:ADP704 3.2 120.7 1.0
MG E:MG705 3.2 99.1 1.0
CE E:LYS288 3.2 111.8 1.0
NZ E:LYS288 3.3 111.8 1.0
CD E:GLU375 3.4 110.4 1.0
O1B E:ADP704 3.5 120.7 1.0
O2B E:ADP704 3.7 120.7 1.0
OE1 E:GLU375 4.0 110.4 1.0
OG E:SER289 4.0 111.7 1.0
NE2 E:GLN537 4.2 123.7 1.0
NH2 E:ARG443 4.5 126.7 1.0
CA E:GLY538 4.5 127.4 1.0
CG E:GLU375 4.5 110.4 1.0
O3A E:ADP704 4.6 120.7 1.0
CD E:LYS288 4.6 111.8 1.0
CB E:LYS288 4.8 111.8 1.0
OE1 E:GLN537 4.9 123.7 1.0
OD1 E:ASP374 4.9 103.4 1.0
CD E:GLN537 5.0 123.7 1.0

Reference:

J.Chen, Q.Wang, B.Malone, E.Llewellyn, Y.Pechersky, K.Maruthi, E.T.Eng, J.K.Perry, E.A.Campbell, D.E.Shaw, S.A.Darst. Ensemble Cryo-Electron Microscopy Reveals Conformational States of the NSP13 Helicase in the Sars-Cov-2 Helicase Replication-Transcription Complex Biorxiv 2021.
DOI: 10.1101/2021.11.10.468168
Page generated: Fri Aug 2 12:02:10 2024

Last articles

Zn in 9JYW
Zn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy