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Atomistry » Fluorine » PDB 7re1-7rrz » 7rpz | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 7re1-7rrz » 7rpz » |
Fluorine in PDB 7rpz: Kras G12D in Complex with Mrtx-1133Enzymatic activity of Kras G12D in Complex with Mrtx-1133
All present enzymatic activity of Kras G12D in Complex with Mrtx-1133:
3.6.5.2; Protein crystallography data
The structure of Kras G12D in Complex with Mrtx-1133, PDB code: 7rpz
was solved by
R.J.Gunn,
N.C.Thomas,
W.Xiaolun,
J.D.Lawson,
M.A.Marx,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7rpz:
The structure of Kras G12D in Complex with Mrtx-1133 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Kras G12D in Complex with Mrtx-1133
(pdb code 7rpz). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Kras G12D in Complex with Mrtx-1133, PDB code: 7rpz: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 7rpzGo back to Fluorine Binding Sites List in 7rpz
Fluorine binding site 1 out
of 3 in the Kras G12D in Complex with Mrtx-1133
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 7rpzGo back to Fluorine Binding Sites List in 7rpz
Fluorine binding site 2 out
of 3 in the Kras G12D in Complex with Mrtx-1133
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 7rpzGo back to Fluorine Binding Sites List in 7rpz
Fluorine binding site 3 out
of 3 in the Kras G12D in Complex with Mrtx-1133
Mono view Stereo pair view
Reference:
X.Wang,
S.Allen,
J.F.Blake,
V.Bowcut,
D.M.Briere,
A.Calinisan,
J.R.Dahlke,
J.B.Fell,
J.P.Fischer,
R.J.Gunn,
J.Hallin,
J.Laguer,
J.D.Lawson,
J.Medwid,
B.Newhouse,
P.Nguyen,
J.M.O'leary,
P.Olson,
S.Pajk,
L.Rahbaek,
M.Rodriguez,
C.R.Smith,
T.P.Tang,
N.C.Thomas,
D.Vanderpool,
G.P.Vigers,
J.G.Christensen,
M.A.Marx.
Identification of MRTX1133, A Noncovalent, Potent, and Selective Kras G12D Inhibitor. J.Med.Chem. 2021.
Page generated: Fri Aug 2 12:20:18 2024
ISSN: ISSN 0022-2623 PubMed: 34889605 DOI: 10.1021/ACS.JMEDCHEM.1C01688 |
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