Fluorine in PDB 7s15: Glp-1 Receptor Bound with Pfizer Small Molecule Agonist

The binding sites of Fluorine atom in the Glp-1 Receptor Bound with Pfizer Small Molecule Agonist (pdb code 7s15). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Glp-1 Receptor Bound with Pfizer Small Molecule Agonist, PDB code: 7s15:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Glp-1 Receptor Bound with Pfizer Small Molecule Agonist


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Glp-1 Receptor Bound with Pfizer Small Molecule Agonist within 5.0Å range: probe atom residue distance (Å) B Occ R:F501 b:103.8 occ:1.00 F39 R:82L501 0.0 103.8 1.0 C38 R:82L501 1.3 103.8 1.0 C33 R:82L501 2.3 103.8 1.0 C37 R:82L501 2.3 103.8 1.0 N30 R:82L501 2.6 103.8 1.0 C32 R:82L501 2.8 103.8 1.0 C21 R:82L501 3.0 103.8 1.0 CB R:TRP203 3.2 105.9 1.0 C22 R:82L501 3.2 103.8 1.0 C25 R:82L501 3.4 103.8 1.0 C29 R:82L501 3.5 103.8 1.0 C36 R:82L501 3.6 103.8 1.0 C34 R:82L501 3.6 103.8 1.0 CE3 R:TRP203 3.6 105.9 1.0 O31 R:82L501 3.6 103.8 1.0 C20 R:82L501 3.9 103.8 1.0 O R:TRP203 3.9 105.9 1.0 CG R:TRP203 3.9 105.9 1.0 CA R:TRP203 4.0 105.9 1.0 CD2 R:TRP203 4.0 105.9 1.0 C35 R:82L501 4.1 103.8 1.0 C R:TRP203 4.4 105.9 1.0 F40 R:82L501 4.7 103.8 1.0 CZ3 R:TRP203 4.7 105.9 1.0 C26 R:82L501 4.7 103.8 1.0 C23 R:82L501 4.7 103.8 1.0 C28 R:82L501 4.8 103.8 1.0

Fluorine binding site 2 out of 2 in the Glp-1 Receptor Bound with Pfizer Small Molecule Agonist


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Glp-1 Receptor Bound with Pfizer Small Molecule Agonist within 5.0Å range: probe atom residue distance (Å) B Occ R:F501 b:103.8 occ:1.00 F40 R:82L501 0.0 103.8 1.0 C36 R:82L501 1.4 103.8 1.0 C35 R:82L501 2.3 103.8 1.0 C37 R:82L501 2.3 103.8 1.0 C38 R:82L501 3.6 103.8 1.0 C34 R:82L501 3.6 103.8 1.0 CB R:LEU217 3.9 116.9 1.0 C33 R:82L501 4.1 103.8 1.0 NE2 R:GLN221 4.2 121.0 1.0 CD1 R:LEU217 4.2 116.9 1.0 CZ3 R:TRP33 4.3 109.3 1.0 O R:LEU217 4.3 116.9 1.0 CA R:LEU217 4.4 116.9 1.0 CG R:LEU217 4.4 116.9 1.0 CD2 R:LEU217 4.5 116.9 1.0 C R:LEU217 4.6 116.9 1.0 F39 R:82L501 4.7 103.8 1.0 CD R:GLN221 4.8 121.0 1.0 CG R:GLN221 4.9 121.0 1.0 CH2 R:TRP33 4.9 109.3 1.0

D.A.Griffith, D.J.Edmonds, J.P.Fortin, A.S.Kalgutkar, J.B.Kuzmiski, P.M.Loria, A.R.Saxena, S.W.Bagley, C.Buckeridge, J.M.Curto, D.R.Derksen, J.M.Dias, M.C.Griffor, S.Han, V.M.Jackson, M.S.Landis, D.Lettiere, C.Limberakis, Y.Liu, A.M.Mathiowetz, J.C.Patel, D.W.Piotrowski, D.A.Price, R.B.Ruggeri, D.A.Tess. A Small-Molecule Oral Agonist of the Human Glucagon-Like Peptide-1 Receptor. J.Med.Chem. V. 65 8208 2022.
ISSN: ISSN 0022-2623
PubMed: 35647711
DOI: 10.1021/ACS.JMEDCHEM.1C01856