|
Atomistry » Fluorine » PDB 7svn-7tfp » 7t47 | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 7svn-7tfp » 7t47 » |
Fluorine in PDB 7t47: Kras G12D (Gppcp) with Mrtx-1133Enzymatic activity of Kras G12D (Gppcp) with Mrtx-1133
All present enzymatic activity of Kras G12D (Gppcp) with Mrtx-1133:
3.6.5.2; Protein crystallography data
The structure of Kras G12D (Gppcp) with Mrtx-1133, PDB code: 7t47
was solved by
N.C.Thomas,
R.J.Gunn,
J.D.Lawson,
X.Wang,
M.A.Matthew,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7t47:
The structure of Kras G12D (Gppcp) with Mrtx-1133 also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Kras G12D (Gppcp) with Mrtx-1133
(pdb code 7t47). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Kras G12D (Gppcp) with Mrtx-1133, PDB code: 7t47: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 7t47Go back to Fluorine Binding Sites List in 7t47
Fluorine binding site 1 out
of 3 in the Kras G12D (Gppcp) with Mrtx-1133
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 7t47Go back to Fluorine Binding Sites List in 7t47
Fluorine binding site 2 out
of 3 in the Kras G12D (Gppcp) with Mrtx-1133
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 7t47Go back to Fluorine Binding Sites List in 7t47
Fluorine binding site 3 out
of 3 in the Kras G12D (Gppcp) with Mrtx-1133
Mono view Stereo pair view
Reference:
J.Christensen,
J.Hallin,
V.Bowcut,
A.Calinsan,
D.Briere,
L.Hargis,
L.Engstrom,
J.Laguer,
J.Medwid,
D.Vanderpool,
E.Lifset,
D.Trinh,
N.Hoffman,
X.Wang,
J.Lawson,
R.Gunn,
C.Smith,
N.Thomas,
M.Martinson,
A.Bergstrom,
F.Sullivan,
K.Bouhana,
S.Winski,
L.He,
F.B.Julio,
A.Pavlicek,
J.Hafing,
L.Rahbaek,
M.Marx,
P.Olson.
A Non-Covalent KRASG12D Allele Specific Inhibitor Demonstrates Potent Inhibition of Kras-Dependent Signaling and Regression of KRASG12D-Mutant Tumors Nature 2022.
Page generated: Fri Aug 2 13:17:34 2024
ISSN: ESSN 1476-4687 DOI: 10.21203/RS.3.RS-1261963/V1 |
Last articlesNa in 4GE8Na in 4GBU Na in 4G8T Na in 4GDX Na in 4GBJ Na in 4GDK Na in 4G8J Na in 4GDL Na in 4G1K Na in 4GBT |
© Copyright 2008-2020 by atomistry.com | ||
Home | Site Map | Copyright | Contact us | Privacy |