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Fluorine in PDB 7tfp: Human Ornithine Aminotransferase Cocrystallized with Its Inhibitor, (1S,3S)-3-Amino-4-(Difluoromethylene)Cyclopentane-1-Carboxylic Acid.Enzymatic activity of Human Ornithine Aminotransferase Cocrystallized with Its Inhibitor, (1S,3S)-3-Amino-4-(Difluoromethylene)Cyclopentane-1-Carboxylic Acid.
All present enzymatic activity of Human Ornithine Aminotransferase Cocrystallized with Its Inhibitor, (1S,3S)-3-Amino-4-(Difluoromethylene)Cyclopentane-1-Carboxylic Acid.:
2.6.1.13; Protein crystallography data
The structure of Human Ornithine Aminotransferase Cocrystallized with Its Inhibitor, (1S,3S)-3-Amino-4-(Difluoromethylene)Cyclopentane-1-Carboxylic Acid., PDB code: 7tfp
was solved by
A.Butrin,
W.Zhu,
R.Silverman,
D.Liu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Human Ornithine Aminotransferase Cocrystallized with Its Inhibitor, (1S,3S)-3-Amino-4-(Difluoromethylene)Cyclopentane-1-Carboxylic Acid.
(pdb code 7tfp). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Human Ornithine Aminotransferase Cocrystallized with Its Inhibitor, (1S,3S)-3-Amino-4-(Difluoromethylene)Cyclopentane-1-Carboxylic Acid., PDB code: 7tfp: Fluorine binding site 1 out of 1 in 7tfpGo back to Fluorine Binding Sites List in 7tfp
Fluorine binding site 1 out
of 1 in the Human Ornithine Aminotransferase Cocrystallized with Its Inhibitor, (1S,3S)-3-Amino-4-(Difluoromethylene)Cyclopentane-1-Carboxylic Acid.
Mono view Stereo pair view
Reference:
W.Zhu,
A.Butrin,
R.D.Melani,
P.F.Doubleday,
G.M.Ferreira,
M.T.Tavares,
T.S.Habeeb Mohammad,
B.A.Beaupre,
N.L.Kelleher,
G.R.Moran,
D.Liu,
R.B.Silverman.
Rational Design, Synthesis, and Mechanism of (3 S ,4 R )-3-Amino-4-(Difluoromethyl)Cyclopent-1-Ene-1-Carboxylic Acid: Employing A Second-Deprotonation Strategy For Selectivity of Human Ornithine Aminotransferase Over Gaba Aminotransferase. J.Am.Chem.Soc. V. 144 5629 2022.
Page generated: Fri Aug 2 13:26:49 2024
ISSN: ESSN 1520-5126 PubMed: 35293728 DOI: 10.1021/JACS.2C00924 |
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