Fluorine in PDB 7ts3: Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine
Enzymatic activity of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine
All present enzymatic activity of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine:
1.14.13.39;
Protein crystallography data
The structure of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine, PDB code: 7ts3
was solved by
H.Li,
T.L.Poulos,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Resolution Low / High (Å)
|
49.59 /
2.10
|
Space group
|
P 1 21 1
|
Cell size a, b, c (Å), α, β, γ (°)
|
52.009,
163.977,
117.315,
90,
90,
90
|
R / Rfree (%)
|
20.1 /
25.3
|
Other elements in 7ts3:
The structure of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine
(pdb code 7ts3). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the
Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine, PDB code: 7ts3:
Jump to Fluorine binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
Fluorine binding site 1 out
of 8 in 7ts3
Go back to
Fluorine Binding Sites List in 7ts3
Fluorine binding site 1 out
of 8 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine
![](/pictures/F/pdb/ts/7ts3-F-sphere_01.jpg) Mono view
![](/pictures/F/pdb/ts/7ts3-F-sphere_01_stereo.jpg) Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F803
b:67.5
occ:1.00
|
F15
|
A:K7U803
|
0.0
|
67.5
|
1.0
|
C13
|
A:K7U803
|
1.3
|
64.1
|
1.0
|
F16
|
A:K7U803
|
2.2
|
66.7
|
1.0
|
C12
|
A:K7U803
|
2.4
|
61.6
|
1.0
|
C14
|
A:K7U803
|
2.4
|
62.5
|
1.0
|
N11
|
A:K7U803
|
2.9
|
61.3
|
1.0
|
O2D
|
A:HEM801
|
3.1
|
57.1
|
1.0
|
CH2
|
A:TRP683
|
3.8
|
29.7
|
1.0
|
OH
|
A:TYR711
|
3.8
|
66.5
|
1.0
|
O
|
A:HOH1105
|
3.9
|
36.6
|
1.0
|
O
|
A:HOH1100
|
4.0
|
54.3
|
1.0
|
CE2
|
A:TYR711
|
4.0
|
43.7
|
1.0
|
CGD
|
A:HEM801
|
4.1
|
47.8
|
1.0
|
CBD
|
A:HEM801
|
4.2
|
40.0
|
1.0
|
CZ3
|
A:TRP683
|
4.2
|
31.2
|
1.0
|
O2A
|
A:HEM801
|
4.4
|
33.3
|
1.0
|
C10
|
A:K7U803
|
4.4
|
57.4
|
1.0
|
CZ
|
A:TYR711
|
4.4
|
54.9
|
1.0
|
O
|
A:HOH1057
|
4.6
|
52.2
|
1.0
|
CZ2
|
A:TRP683
|
4.9
|
29.2
|
1.0
|
|
Fluorine binding site 2 out
of 8 in 7ts3
Go back to
Fluorine Binding Sites List in 7ts3
Fluorine binding site 2 out
of 8 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine
![](/pictures/F/pdb/ts/7ts3-F-sphere_02.jpg) Mono view
![](/pictures/F/pdb/ts/7ts3-F-sphere_02_stereo.jpg) Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F803
b:66.7
occ:1.00
|
F16
|
A:K7U803
|
0.0
|
66.7
|
1.0
|
C13
|
A:K7U803
|
1.3
|
64.1
|
1.0
|
F15
|
A:K7U803
|
2.2
|
67.5
|
1.0
|
O
|
A:HOH1105
|
2.2
|
36.6
|
1.0
|
C14
|
A:K7U803
|
2.4
|
62.5
|
1.0
|
C12
|
A:K7U803
|
2.4
|
61.6
|
1.0
|
N11
|
A:K7U803
|
3.1
|
61.3
|
1.0
|
CBD
|
A:HEM801
|
3.7
|
40.0
|
1.0
|
CG1
|
A:VAL572
|
3.8
|
30.7
|
1.0
|
SD
|
A:MET575
|
3.8
|
37.6
|
1.0
|
CG2
|
A:VAL572
|
3.8
|
31.3
|
1.0
|
O2D
|
A:HEM801
|
3.9
|
57.1
|
1.0
|
C10
|
A:K7U803
|
4.0
|
57.4
|
1.0
|
C09
|
A:K7U803
|
4.3
|
55.1
|
1.0
|
CGD
|
A:HEM801
|
4.4
|
47.8
|
1.0
|
CB
|
A:VAL572
|
4.4
|
29.7
|
1.0
|
CG
|
A:MET575
|
4.6
|
30.3
|
1.0
|
CE2
|
A:TYR711
|
4.7
|
43.7
|
1.0
|
CAD
|
A:HEM801
|
4.7
|
32.8
|
1.0
|
C08
|
A:K7U803
|
4.9
|
48.2
|
1.0
|
|
Fluorine binding site 3 out
of 8 in 7ts3
Go back to
Fluorine Binding Sites List in 7ts3
Fluorine binding site 3 out
of 8 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine
![](/pictures/F/pdb/ts/7ts3-F-sphere_03.jpg) Mono view
![](/pictures/F/pdb/ts/7ts3-F-sphere_03_stereo.jpg) Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F803
b:72.8
occ:1.00
|
F15
|
B:K7U803
|
0.0
|
72.8
|
1.0
|
C13
|
B:K7U803
|
1.3
|
70.1
|
1.0
|
F16
|
B:K7U803
|
2.2
|
75.9
|
1.0
|
C14
|
B:K7U803
|
2.4
|
68.0
|
1.0
|
C12
|
B:K7U803
|
2.4
|
67.9
|
1.0
|
O2D
|
B:HEM801
|
2.8
|
41.2
|
1.0
|
N11
|
B:K7U803
|
3.0
|
67.1
|
1.0
|
OH
|
B:TYR711
|
3.0
|
59.9
|
1.0
|
CH2
|
B:TRP683
|
3.4
|
31.9
|
1.0
|
CBD
|
B:HEM801
|
3.4
|
33.5
|
1.0
|
CGD
|
B:HEM801
|
3.6
|
43.3
|
1.0
|
CZ3
|
B:TRP683
|
3.7
|
28.2
|
1.0
|
O
|
B:HOH1143
|
3.8
|
28.0
|
1.0
|
CZ
|
B:TYR711
|
4.1
|
56.6
|
1.0
|
CE2
|
B:TYR711
|
4.2
|
56.5
|
1.0
|
C10
|
B:K7U803
|
4.3
|
58.0
|
1.0
|
O2A
|
B:HEM801
|
4.4
|
44.0
|
1.0
|
CZ2
|
B:TRP683
|
4.5
|
34.8
|
1.0
|
CAD
|
B:HEM801
|
4.6
|
30.9
|
1.0
|
O1D
|
B:HEM801
|
4.9
|
43.0
|
1.0
|
C09
|
B:K7U803
|
4.9
|
60.0
|
1.0
|
O
|
B:HOH1076
|
4.9
|
42.7
|
1.0
|
O
|
B:HOH1009
|
5.0
|
43.9
|
1.0
|
|
Fluorine binding site 4 out
of 8 in 7ts3
Go back to
Fluorine Binding Sites List in 7ts3
Fluorine binding site 4 out
of 8 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine
![](/pictures/F/pdb/ts/7ts3-F-sphere_04.jpg) Mono view
![](/pictures/F/pdb/ts/7ts3-F-sphere_04_stereo.jpg) Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
B:F803
b:75.9
occ:1.00
|
F16
|
B:K7U803
|
0.0
|
75.9
|
1.0
|
C13
|
B:K7U803
|
1.3
|
70.1
|
1.0
|
F15
|
B:K7U803
|
2.2
|
72.8
|
1.0
|
O
|
B:HOH1143
|
2.3
|
28.0
|
1.0
|
C12
|
B:K7U803
|
2.3
|
67.9
|
1.0
|
C14
|
B:K7U803
|
2.4
|
68.0
|
1.0
|
N11
|
B:K7U803
|
3.1
|
67.1
|
1.0
|
CBD
|
B:HEM801
|
3.6
|
33.5
|
1.0
|
CG2
|
B:VAL572
|
3.7
|
24.0
|
1.0
|
CG1
|
B:VAL572
|
3.8
|
24.7
|
1.0
|
C10
|
B:K7U803
|
3.8
|
58.0
|
1.0
|
SD
|
B:MET575
|
4.0
|
34.6
|
1.0
|
O2D
|
B:HEM801
|
4.1
|
41.2
|
1.0
|
C09
|
B:K7U803
|
4.2
|
60.0
|
1.0
|
CB
|
B:VAL572
|
4.3
|
24.8
|
1.0
|
CGD
|
B:HEM801
|
4.4
|
43.3
|
1.0
|
OH
|
B:TYR711
|
4.4
|
59.9
|
1.0
|
CG
|
B:MET575
|
4.7
|
30.0
|
1.0
|
CE2
|
B:TYR711
|
4.8
|
56.5
|
1.0
|
CAD
|
B:HEM801
|
4.8
|
30.9
|
1.0
|
O
|
B:HOH1009
|
4.8
|
43.9
|
1.0
|
C08
|
B:K7U803
|
4.9
|
57.1
|
1.0
|
|
Fluorine binding site 5 out
of 8 in 7ts3
Go back to
Fluorine Binding Sites List in 7ts3
Fluorine binding site 5 out
of 8 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine
![](/pictures/F/pdb/ts/7ts3-F-sphere_05.jpg) Mono view
![](/pictures/F/pdb/ts/7ts3-F-sphere_05_stereo.jpg) Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:F803
b:69.6
occ:1.00
|
F15
|
C:K7U803
|
0.0
|
69.6
|
1.0
|
C13
|
C:K7U803
|
1.3
|
67.9
|
1.0
|
F16
|
C:K7U803
|
2.2
|
73.2
|
1.0
|
C12
|
C:K7U803
|
2.4
|
64.1
|
1.0
|
C14
|
C:K7U803
|
2.4
|
66.0
|
1.0
|
O2D
|
C:HEM801
|
2.6
|
53.3
|
1.0
|
N11
|
C:K7U803
|
3.0
|
65.3
|
1.0
|
CBD
|
C:HEM801
|
3.4
|
37.9
|
1.0
|
CGD
|
C:HEM801
|
3.5
|
47.1
|
1.0
|
O
|
C:HOH1103
|
3.7
|
42.9
|
1.0
|
CH2
|
C:TRP683
|
3.7
|
30.7
|
1.0
|
OH
|
C:TYR711
|
3.7
|
73.1
|
1.0
|
CZ3
|
C:TRP683
|
3.9
|
36.2
|
1.0
|
CE2
|
C:TYR711
|
4.1
|
53.7
|
1.0
|
O2A
|
C:HEM801
|
4.4
|
41.4
|
1.0
|
C10
|
C:K7U803
|
4.4
|
57.9
|
1.0
|
CZ
|
C:TYR711
|
4.4
|
65.5
|
1.0
|
O
|
C:HOH1104
|
4.5
|
53.3
|
1.0
|
CAD
|
C:HEM801
|
4.5
|
33.4
|
1.0
|
O1D
|
C:HEM801
|
4.7
|
36.0
|
1.0
|
CZ2
|
C:TRP683
|
4.8
|
33.7
|
1.0
|
SD
|
C:MET575
|
5.0
|
35.6
|
1.0
|
|
Fluorine binding site 6 out
of 8 in 7ts3
Go back to
Fluorine Binding Sites List in 7ts3
Fluorine binding site 6 out
of 8 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine
![](/pictures/F/pdb/ts/7ts3-F-sphere_06.jpg) Mono view
![](/pictures/F/pdb/ts/7ts3-F-sphere_06_stereo.jpg) Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
C:F803
b:73.2
occ:1.00
|
F16
|
C:K7U803
|
0.0
|
73.2
|
1.0
|
C13
|
C:K7U803
|
1.3
|
67.9
|
1.0
|
F15
|
C:K7U803
|
2.2
|
69.6
|
1.0
|
C12
|
C:K7U803
|
2.4
|
64.1
|
1.0
|
C14
|
C:K7U803
|
2.4
|
66.0
|
1.0
|
O
|
C:HOH1103
|
2.5
|
42.9
|
1.0
|
N11
|
C:K7U803
|
3.1
|
65.3
|
1.0
|
CG2
|
C:VAL572
|
3.7
|
23.4
|
1.0
|
CG1
|
C:VAL572
|
3.8
|
19.9
|
1.0
|
C10
|
C:K7U803
|
3.8
|
57.9
|
1.0
|
SD
|
C:MET575
|
3.9
|
35.6
|
1.0
|
CBD
|
C:HEM801
|
3.9
|
37.9
|
1.0
|
O2D
|
C:HEM801
|
4.1
|
53.3
|
1.0
|
CB
|
C:VAL572
|
4.4
|
25.2
|
1.0
|
C09
|
C:K7U803
|
4.4
|
52.6
|
1.0
|
CG
|
C:MET575
|
4.5
|
29.5
|
1.0
|
CGD
|
C:HEM801
|
4.5
|
47.1
|
1.0
|
OD1
|
C:ASN574
|
4.7
|
25.9
|
1.0
|
CE2
|
C:TYR711
|
4.8
|
53.7
|
1.0
|
O
|
C:HOH928
|
4.9
|
59.8
|
1.0
|
|
Fluorine binding site 7 out
of 8 in 7ts3
Go back to
Fluorine Binding Sites List in 7ts3
Fluorine binding site 7 out
of 8 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine
![](/pictures/F/pdb/ts/7ts3-F-sphere_07.jpg) Mono view
![](/pictures/F/pdb/ts/7ts3-F-sphere_07_stereo.jpg) Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:F803
b:86.0
occ:1.00
|
F15
|
D:K7U803
|
0.0
|
86.0
|
1.0
|
C13
|
D:K7U803
|
1.3
|
86.1
|
1.0
|
F16
|
D:K7U803
|
2.2
|
94.5
|
1.0
|
C14
|
D:K7U803
|
2.4
|
84.0
|
1.0
|
C12
|
D:K7U803
|
2.4
|
84.2
|
1.0
|
O2D
|
D:HEM801
|
2.7
|
48.5
|
1.0
|
N11
|
D:K7U803
|
3.0
|
79.9
|
1.0
|
OH
|
D:TYR711
|
3.1
|
66.2
|
1.0
|
CBD
|
D:HEM801
|
3.3
|
45.4
|
1.0
|
CGD
|
D:HEM801
|
3.4
|
46.3
|
1.0
|
CE2
|
D:TYR711
|
3.6
|
51.6
|
1.0
|
CH2
|
D:TRP683
|
3.7
|
23.2
|
1.0
|
CZ
|
D:TYR711
|
3.8
|
57.7
|
1.0
|
O
|
D:HOH1133
|
3.9
|
93.6
|
1.0
|
CZ3
|
D:TRP683
|
4.1
|
23.8
|
1.0
|
C10
|
D:K7U803
|
4.3
|
65.1
|
1.0
|
CAD
|
D:HEM801
|
4.3
|
37.4
|
1.0
|
SD
|
D:MET575
|
4.5
|
31.9
|
1.0
|
O
|
D:HOH1140
|
4.6
|
31.0
|
1.0
|
O1D
|
D:HEM801
|
4.6
|
40.2
|
1.0
|
CZ2
|
D:TRP683
|
4.7
|
28.5
|
1.0
|
CD2
|
D:TYR711
|
4.8
|
44.8
|
1.0
|
O
|
D:HOH1034
|
4.9
|
47.6
|
1.0
|
O2A
|
D:HEM801
|
4.9
|
39.6
|
1.0
|
|
Fluorine binding site 8 out
of 8 in 7ts3
Go back to
Fluorine Binding Sites List in 7ts3
Fluorine binding site 8 out
of 8 in the Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine
![](/pictures/F/pdb/ts/7ts3-F-sphere_08.jpg) Mono view
![](/pictures/F/pdb/ts/7ts3-F-sphere_08_stereo.jpg) Stereo pair view
|
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Structure of Human Neuronal Nitric Oxide Synthase R354A/G357D Mutant Heme Domain in Complex with 6-(3-(3,3-Difluoroazetidin-1-Yl)Prop-1- Yn-1-Yl)-4-Methylpyridin-2-Amine within 5.0Å range:
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
D:F803
b:94.5
occ:1.00
|
F16
|
D:K7U803
|
0.0
|
94.5
|
1.0
|
C13
|
D:K7U803
|
1.3
|
86.1
|
1.0
|
F15
|
D:K7U803
|
2.2
|
86.0
|
1.0
|
C14
|
D:K7U803
|
2.4
|
84.0
|
1.0
|
C12
|
D:K7U803
|
2.4
|
84.2
|
1.0
|
N11
|
D:K7U803
|
3.0
|
79.9
|
1.0
|
O
|
D:HOH1034
|
3.3
|
47.6
|
1.0
|
C10
|
D:K7U803
|
3.6
|
65.1
|
1.0
|
O
|
D:HOH1114
|
3.9
|
31.9
|
1.0
|
O
|
D:HOH1024
|
4.0
|
47.2
|
1.0
|
O
|
D:HOH1133
|
4.3
|
93.6
|
1.0
|
CG1
|
D:VAL572
|
4.3
|
23.8
|
1.0
|
OD1
|
D:ASN574
|
4.4
|
27.2
|
1.0
|
CE2
|
D:TYR711
|
4.4
|
51.6
|
1.0
|
CG2
|
D:VAL572
|
4.4
|
20.7
|
1.0
|
O
|
D:HOH1140
|
4.5
|
31.0
|
1.0
|
C09
|
D:K7U803
|
4.6
|
60.5
|
1.0
|
SD
|
D:MET575
|
4.7
|
31.9
|
1.0
|
OH
|
D:TYR711
|
4.8
|
66.2
|
1.0
|
O2D
|
D:HEM801
|
4.9
|
48.5
|
1.0
|
CG
|
D:MET575
|
5.0
|
27.6
|
1.0
|
|
Reference:
D.Vasu,
H.Li,
C.D.Hardy,
T.L.Poulos,
R.B.Silverman.
2-Aminopyridines with A Shortened Amino Sidechain As Potent, Selective, and Highly Permeable Human Neuronal Nitric Oxide Synthase Inhibitors. Bioorg.Med.Chem. V. 69 16878 2022.
ISSN: ESSN 1464-3391
PubMed: 35772285
DOI: 10.1016/J.BMC.2022.116878
Page generated: Fri Aug 2 13:38:55 2024
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