Fluorine in PDB 7ty8: Cryo-Em Structure of Human Anion Exchanger 1 Bound to Niflumic Acid

The binding sites of Fluorine atom in the Cryo-Em Structure of Human Anion Exchanger 1 Bound to Niflumic Acid (pdb code 7ty8). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Cryo-Em Structure of Human Anion Exchanger 1 Bound to Niflumic Acid, PDB code: 7ty8:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Cryo-Em Structure of Human Anion Exchanger 1 Bound to Niflumic Acid


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of Human Anion Exchanger 1 Bound to Niflumic Acid within 5.0Å range: probe atom residue distance (Å) B Occ A:F2204 b:153.3 occ:1.00 F3 A:NFL2204 0.0 153.3 1.0 C15 A:NFL2204 1.3 152.6 1.0 F2 A:NFL2204 2.1 149.4 1.0 F1 A:NFL2204 2.1 154.4 1.0 C9 A:NFL2204 2.3 152.8 1.0 C10 A:NFL2204 2.8 154.0 1.0 O A:LEU677 3.2 76.0 1.0 CG A:PRO860 3.3 105.1 1.0 CA A:LEU677 3.4 77.6 1.0 C14 A:NFL2204 3.5 153.4 1.0 CB A:PRO860 3.7 105.3 1.0 C A:LEU677 3.8 74.2 1.0 CG A:LEU677 3.9 83.9 1.0 CB A:LEU677 4.0 80.5 1.0 C11 A:NFL2204 4.1 152.7 1.0 CA A:PRO860 4.3 105.7 1.0 CB A:LEU680 4.3 72.2 1.0 CD A:PRO860 4.3 104.5 1.0 N A:LEU677 4.4 77.4 1.0 O A:ILE676 4.4 77.8 1.0 N A:GLU681 4.5 70.8 1.0 N1 A:NFL2204 4.6 154.4 1.0 N A:PRO860 4.6 104.8 1.0 C13 A:NFL2204 4.7 153.0 1.0 C A:ILE676 4.8 75.7 1.0 CD1 A:LEU677 4.8 85.1 1.0 CB A:GLU681 4.8 75.5 1.0 CD2 A:LEU677 4.8 86.8 1.0 C A:LEU680 4.9 70.0 1.0 C12 A:NFL2204 4.9 151.6 1.0 CB A:PRO467 4.9 75.0 1.0

Fluorine binding site 2 out of 6 in the Cryo-Em Structure of Human Anion Exchanger 1 Bound to Niflumic Acid


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of Human Anion Exchanger 1 Bound to Niflumic Acid within 5.0Å range: probe atom residue distance (Å) B Occ A:F2204 b:154.4 occ:1.00 F1 A:NFL2204 0.0 154.4 1.0 C15 A:NFL2204 1.3 152.6 1.0 F3 A:NFL2204 2.1 153.3 1.0 F2 A:NFL2204 2.1 149.4 1.0 C9 A:NFL2204 2.4 152.8 1.0 C10 A:NFL2204 3.1 154.0 1.0 C14 A:NFL2204 3.3 153.4 1.0 CD2 A:LEU863 3.3 90.0 1.0 CB A:LEU680 3.4 72.2 1.0 CA A:PRO860 3.8 105.7 1.0 CB A:PRO860 3.9 105.3 1.0 C A:LEU680 4.2 70.0 1.0 CG A:PRO860 4.2 105.1 1.0 CD1 A:LEU680 4.2 72.5 1.0 N A:GLU681 4.3 70.8 1.0 C11 A:NFL2204 4.4 152.7 1.0 O A:LEU680 4.4 72.1 1.0 CA A:LEU680 4.4 70.7 1.0 CG A:LEU680 4.4 73.9 1.0 C13 A:NFL2204 4.5 153.0 1.0 N A:PRO860 4.5 104.8 1.0 CG A:LEU863 4.5 91.7 1.0 CE2 A:PHE524 4.6 59.6 1.0 O A:LEU677 4.6 76.0 1.0 CB A:LEU863 4.6 92.2 1.0 CD A:PRO860 4.9 104.5 1.0 C12 A:NFL2204 4.9 151.6 1.0 CA A:GLU681 4.9 70.6 1.0 CD2 A:PHE524 4.9 61.4 1.0

Fluorine binding site 3 out of 6 in the Cryo-Em Structure of Human Anion Exchanger 1 Bound to Niflumic Acid


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of Human Anion Exchanger 1 Bound to Niflumic Acid within 5.0Å range: probe atom residue distance (Å) B Occ A:F2204 b:149.4 occ:1.00 F2 A:NFL2204 0.0 149.4 1.0 C15 A:NFL2204 1.3 152.6 1.0 F3 A:NFL2204 2.1 153.3 1.0 F1 A:NFL2204 2.1 154.4 1.0 C9 A:NFL2204 2.4 152.8 1.0 N A:GLU681 2.6 70.8 1.0 C14 A:NFL2204 2.8 153.4 1.0 O A:LEU677 2.9 76.0 1.0 CA A:GLU681 3.0 70.6 1.0 C A:LEU680 3.1 70.0 1.0 CB A:GLU681 3.2 75.5 1.0 CB A:LEU680 3.6 72.2 1.0 C10 A:NFL2204 3.6 154.0 1.0 O A:LEU680 3.6 72.1 1.0 CA A:LEU680 3.8 70.7 1.0 C A:LEU677 4.0 74.2 1.0 C13 A:NFL2204 4.1 153.0 1.0 CE2 A:PHE524 4.2 59.6 1.0 OE1 A:GLU681 4.2 87.4 1.0 CA A:LEU677 4.3 77.6 1.0 N A:LEU680 4.4 71.2 1.0 CG A:GLU681 4.4 80.3 1.0 CD A:GLU681 4.5 86.0 1.0 C A:GLU681 4.5 64.7 1.0 O A:ILE676 4.6 77.8 1.0 C11 A:NFL2204 4.7 152.7 1.0 CD2 A:LEU863 4.8 90.0 1.0 CZ A:PHE524 4.9 59.1 1.0 C12 A:NFL2204 4.9 151.6 1.0 CG A:LEU680 5.0 73.9 1.0

Fluorine binding site 4 out of 6 in the Cryo-Em Structure of Human Anion Exchanger 1 Bound to Niflumic Acid


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Cryo-Em Structure of Human Anion Exchanger 1 Bound to Niflumic Acid within 5.0Å range: probe atom residue distance (Å) B Occ B:F2204 b:145.8 occ:1.00 F3 B:NFL2204 0.0 145.8 1.0 C15 B:NFL2204 1.3 145.3 1.0 F1 B:NFL2204 2.1 145.9 1.0 F2 B:NFL2204 2.1 142.1 1.0 C9 B:NFL2204 2.4 146.3 1.0 CD2 B:LEU863 3.1 90.0 1.0 C10 B:NFL2204 3.1 146.9 1.0 C14 B:NFL2204 3.3 147.3 1.0 CB B:LEU680 3.9 72.3 1.0 CA B:PRO860 4.0 106.2 1.0 CB B:PRO860 4.2 105.9 1.0 CG B:LEU863 4.4 91.7 1.0 CE2 B:PHE524 4.4 59.3 1.0 C11 B:NFL2204 4.4 145.6 1.0 CG B:PRO860 4.4 105.7 1.0 CB B:LEU863 4.4 92.2 1.0 N B:PRO860 4.5 105.3 1.0 C13 B:NFL2204 4.5 146.7 1.0 C B:LEU680 4.5 70.0 1.0 CD1 B:LEU680 4.6 72.7 1.0 O B:LEU680 4.6 72.1 1.0 N B:GLU681 4.6 70.8 1.0 CD2 B:PHE524 4.7 61.2 1.0 CA B:LEU680 4.8 70.8 1.0 CG B:LEU680 4.9 74.1 1.0 CD B:PRO860 4.9 105.1 1.0 C12 B:NFL2204 4.9 145.5 1.0 O B:LEU677 4.9 76.2 1.0 C B:LEU859 5.0 105.0 1.0

Fluorine binding site 5 out of 6 in the Cryo-Em Structure of Human Anion Exchanger 1 Bound to Niflumic Acid


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Cryo-Em Structure of Human Anion Exchanger 1 Bound to Niflumic Acid within 5.0Å range: probe atom residue distance (Å) B Occ B:F2204 b:145.9 occ:1.00 F1 B:NFL2204 0.0 145.9 1.0 C15 B:NFL2204 1.3 145.3 1.0 F2 B:NFL2204 2.1 142.1 1.0 F3 B:NFL2204 2.1 145.8 1.0 C9 B:NFL2204 2.4 146.3 1.0 C10 B:NFL2204 2.8 146.9 1.0 CG B:PRO860 3.3 105.7 1.0 C14 B:NFL2204 3.5 147.3 1.0 O B:LEU677 3.6 76.2 1.0 CB B:PRO860 3.7 105.9 1.0 CA B:LEU677 3.8 77.7 1.0 CG B:LEU677 4.1 84.0 1.0 C11 B:NFL2204 4.2 145.6 1.0 CA B:PRO860 4.2 106.2 1.0 CD B:PRO860 4.2 105.1 1.0 C B:LEU677 4.2 74.2 1.0 CB B:LEU677 4.4 80.5 1.0 N B:PRO860 4.4 105.3 1.0 CB B:LEU680 4.5 72.3 1.0 C13 B:NFL2204 4.7 146.7 1.0 N1 B:NFL2204 4.7 146.7 1.0 N B:GLU681 4.7 70.8 1.0 N B:LEU677 4.8 77.4 1.0 CB B:PRO467 4.9 75.5 1.0 O B:ILE676 4.9 77.7 1.0 C12 B:NFL2204 4.9 145.5 1.0 CD2 B:LEU677 5.0 87.0 1.0 CG B:PRO467 5.0 76.1 1.0 CD1 B:LEU677 5.0 85.2 1.0

Fluorine binding site 6 out of 6 in the Cryo-Em Structure of Human Anion Exchanger 1 Bound to Niflumic Acid


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Cryo-Em Structure of Human Anion Exchanger 1 Bound to Niflumic Acid within 5.0Å range: probe atom residue distance (Å) B Occ B:F2204 b:142.1 occ:1.00 F2 B:NFL2204 0.0 142.1 1.0 C15 B:NFL2204 1.3 145.3 1.0 F1 B:NFL2204 2.1 145.9 1.0 F3 B:NFL2204 2.1 145.8 1.0 C9 B:NFL2204 2.4 146.3 1.0 C14 B:NFL2204 2.8 147.3 1.0 N B:GLU681 2.9 70.8 1.0 O B:LEU677 3.2 76.2 1.0 CA B:GLU681 3.2 70.7 1.0 C B:LEU680 3.4 70.0 1.0 CB B:GLU681 3.4 75.6 1.0 C10 B:NFL2204 3.6 146.9 1.0 O B:LEU680 3.8 72.1 1.0 CB B:LEU680 3.8 72.3 1.0 CE2 B:PHE524 4.0 59.3 1.0 CA B:LEU680 4.1 70.8 1.0 C13 B:NFL2204 4.1 146.7 1.0 OE1 B:GLU681 4.1 87.4 1.0 C B:LEU677 4.3 74.2 1.0 CD B:GLU681 4.5 86.0 1.0 CG B:GLU681 4.5 80.3 1.0 CA B:LEU677 4.6 77.7 1.0 CD2 B:LEU863 4.7 90.0 1.0 N B:LEU680 4.7 71.2 1.0 C11 B:NFL2204 4.7 145.6 1.0 C B:GLU681 4.7 64.7 1.0 CZ B:PHE524 4.8 58.8 1.0 CD2 B:PHE524 4.9 61.2 1.0 C12 B:NFL2204 4.9 145.5 1.0 O B:ILE676 4.9 77.7 1.0

M.J.Capper, S.Yang, A.C.Stone, S.Vatansever, G.Zilberg, Y.K.Mathiharan, R.Habib, K.Hutchinson, A.Schlessinger, M.Mezei, R.Osman, B.Zhang, D.Wacker. Substrate Binding and Inhibition of the Anion Exchanger 1 Bicarbonate Transporter To Be Published.