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Fluorine in PDB 7u30: PRMT5:MEP50 Complexed with Cyclonucleoside Compound 1Enzymatic activity of PRMT5:MEP50 Complexed with Cyclonucleoside Compound 1
All present enzymatic activity of PRMT5:MEP50 Complexed with Cyclonucleoside Compound 1:
2.1.1.320; Protein crystallography data
The structure of PRMT5:MEP50 Complexed with Cyclonucleoside Compound 1, PDB code: 7u30
was solved by
R.L.Palte,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the PRMT5:MEP50 Complexed with Cyclonucleoside Compound 1
(pdb code 7u30). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the PRMT5:MEP50 Complexed with Cyclonucleoside Compound 1, PDB code: 7u30: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 7u30Go back to Fluorine Binding Sites List in 7u30
Fluorine binding site 1 out
of 2 in the PRMT5:MEP50 Complexed with Cyclonucleoside Compound 1
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 7u30Go back to Fluorine Binding Sites List in 7u30
Fluorine binding site 2 out
of 2 in the PRMT5:MEP50 Complexed with Cyclonucleoside Compound 1
Mono view Stereo pair view
Reference:
S.Kawamura,
R.L.Palte,
H.Y.Kim,
J.Sauri,
C.Sondey,
M.S.Mansueto,
M.D.Altman,
M.R.Machacek.
Design and Synthesis of Unprecedented 9- and 10-Membered Cyclonucleosides with PRMT5 Inhibitory Activity. Bioorg.Med.Chem. V. 66 16820 2022.
Page generated: Fri Aug 2 13:53:12 2024
ISSN: ESSN 1464-3391 PubMed: 35594650 DOI: 10.1016/J.BMC.2022.116820 |
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