Fluorine in PDB 7u5x: Crystal Structure Analysis of Human Carbonic Anhydrase 2
Enzymatic activity of Crystal Structure Analysis of Human Carbonic Anhydrase 2
All present enzymatic activity of Crystal Structure Analysis of Human Carbonic Anhydrase 2:
4.2.1.1;
Protein crystallography data
The structure of Crystal Structure Analysis of Human Carbonic Anhydrase 2, PDB code: 7u5x
was solved by
H.-S.Seo,
S.Dhe-Paganon,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
|
Resolution Low / High (Å)
|
69.88 /
1.04
|
|
Space group
|
P 1 21 1
|
|
Cell size a, b, c (Å), α, β, γ (°)
|
42.23,
41.26,
72.07,
90,
104.17,
90
|
|
R / Rfree (%)
|
14.7 /
17.1
|
Other elements in 7u5x:
The structure of Crystal Structure Analysis of Human Carbonic Anhydrase 2 also contains other interesting chemical elements:
Fluorine Binding Sites:
Pages:
>>> Page 1 <<<
Page 2, Binding sites: 11 -
14;
Binding sites:
The binding sites of Fluorine atom in the Crystal Structure Analysis of Human Carbonic Anhydrase 2
(pdb code 7u5x). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 14 binding sites of Fluorine where determined in the
Crystal Structure Analysis of Human Carbonic Anhydrase 2, PDB code: 7u5x:
Jump to Fluorine binding site number:
1;
2;
3;
4;
5;
6;
7;
8;
9;
10;
Fluorine binding site 1 out
of 14 in 7u5x
Go back to
Fluorine Binding Sites List in 7u5x
Fluorine binding site 1 out
of 14 in the Crystal Structure Analysis of Human Carbonic Anhydrase 2
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure Analysis of Human Carbonic Anhydrase 2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F7
b:14.1
occ:0.31
|
F
|
A:YOF7
|
0.0
|
14.1
|
0.3
|
|
CE2
|
A:YOF7
|
1.2
|
11.9
|
0.7
|
|
CE1
|
A:YOF7
|
1.4
|
12.9
|
0.3
|
|
CD2
|
A:YOF7
|
2.2
|
13.7
|
0.7
|
|
CZ
|
A:YOF7
|
2.2
|
12.8
|
0.7
|
|
CD1
|
A:YOF7
|
2.4
|
14.3
|
0.3
|
|
CZ
|
A:YOF7
|
2.4
|
13.0
|
0.3
|
|
OH
|
A:YOF7
|
2.7
|
12.1
|
0.7
|
|
OH
|
A:YOF7
|
2.8
|
12.3
|
0.3
|
|
O
|
A:HOH421
|
2.9
|
12.7
|
1.0
|
|
C
|
A:TRP244
|
3.0
|
11.4
|
1.0
|
|
N
|
A:ARG245
|
3.1
|
10.7
|
1.0
|
|
O
|
A:TRP244
|
3.3
|
11.5
|
1.0
|
|
CH2
|
A:TRP16
|
3.3
|
12.8
|
1.0
|
|
CG
|
A:YOF7
|
3.5
|
15.2
|
0.7
|
|
CE1
|
A:YOF7
|
3.5
|
14.1
|
0.7
|
|
N
|
A:TRP244
|
3.5
|
11.0
|
1.0
|
|
CA
|
A:TRP244
|
3.6
|
10.5
|
1.0
|
|
C
|
A:ASN243
|
3.6
|
11.1
|
1.0
|
|
CG
|
A:YOF7
|
3.6
|
14.9
|
0.3
|
|
CE2
|
A:YOF7
|
3.7
|
13.2
|
0.3
|
|
CA
|
A:ARG245
|
3.7
|
11.2
|
1.0
|
|
CZ2
|
A:TRP16
|
3.7
|
12.8
|
1.0
|
|
O
|
A:ASN243
|
3.7
|
12.4
|
1.0
|
|
CD1
|
A:YOF7
|
4.0
|
15.7
|
0.7
|
|
CB
|
A:ARG245
|
4.0
|
11.5
|
1.0
|
|
CG
|
A:PRO13
|
4.0
|
15.8
|
1.0
|
|
CD2
|
A:YOF7
|
4.1
|
14.4
|
0.3
|
|
OE2
|
A:GLU106
|
4.3
|
11.3
|
1.0
|
|
CZ3
|
A:TRP16
|
4.4
|
12.2
|
1.0
|
|
CA
|
A:ASN243
|
4.5
|
11.1
|
1.0
|
|
F
|
A:YOF7
|
4.6
|
15.3
|
0.7
|
|
CD
|
A:PRO13
|
4.7
|
15.6
|
1.0
|
|
CB
|
A:YOF7
|
4.7
|
17.4
|
0.7
|
|
CB
|
A:YOF7
|
4.9
|
16.8
|
0.3
|
|
O
|
A:THR198
|
4.9
|
11.1
|
1.0
|
|
Fluorine binding site 2 out
of 14 in 7u5x
Go back to
Fluorine Binding Sites List in 7u5x
Fluorine binding site 2 out
of 14 in the Crystal Structure Analysis of Human Carbonic Anhydrase 2
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure Analysis of Human Carbonic Anhydrase 2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F7
b:15.3
occ:0.69
|
F
|
A:YOF7
|
0.0
|
15.3
|
0.7
|
|
CE2
|
A:YOF7
|
1.3
|
13.2
|
0.3
|
|
CE1
|
A:YOF7
|
1.3
|
14.1
|
0.7
|
|
CZ
|
A:YOF7
|
2.2
|
13.0
|
0.3
|
|
CD1
|
A:YOF7
|
2.4
|
15.7
|
0.7
|
|
CZ
|
A:YOF7
|
2.4
|
12.8
|
0.7
|
|
CD2
|
A:YOF7
|
2.4
|
14.4
|
0.3
|
|
OH
|
A:YOF7
|
2.5
|
12.3
|
0.3
|
|
OH
|
A:YOF7
|
2.8
|
12.1
|
0.7
|
|
CB
|
A:HIS64
|
3.1
|
19.1
|
1.0
|
|
O
|
A:HOH553
|
3.2
|
16.2
|
1.0
|
|
O
|
A:HIS64
|
3.4
|
16.4
|
1.0
|
|
CA
|
A:HIS64
|
3.4
|
15.4
|
1.0
|
|
CD2
|
A:HIS64
|
3.5
|
24.5
|
1.0
|
|
CE1
|
A:YOF7
|
3.5
|
12.9
|
0.3
|
|
CG
|
A:HIS64
|
3.6
|
23.5
|
1.0
|
|
CZ3
|
A:TRP5
|
3.6
|
16.7
|
1.0
|
|
CG
|
A:YOF7
|
3.6
|
14.9
|
0.3
|
|
CE2
|
A:YOF7
|
3.6
|
11.9
|
0.7
|
|
CG
|
A:YOF7
|
3.6
|
15.2
|
0.7
|
|
O
|
A:HOH603
|
3.7
|
24.5
|
1.0
|
|
C
|
A:HIS64
|
3.8
|
14.3
|
1.0
|
|
CB
|
A:ASN243
|
4.0
|
11.8
|
1.0
|
|
CH2
|
A:TRP5
|
4.1
|
17.6
|
1.0
|
|
CD1
|
A:YOF7
|
4.1
|
14.3
|
0.3
|
|
CD2
|
A:YOF7
|
4.1
|
13.7
|
0.7
|
|
CE1
|
A:PHE230
|
4.5
|
16.2
|
1.0
|
|
CA
|
A:ASN243
|
4.6
|
11.1
|
1.0
|
|
O
|
A:ASN243
|
4.6
|
12.4
|
1.0
|
|
F
|
A:YOF7
|
4.6
|
14.1
|
0.3
|
|
CE3
|
A:TRP5
|
4.6
|
15.7
|
1.0
|
|
NE2
|
A:HIS64
|
4.8
|
25.9
|
1.0
|
|
N
|
A:HIS64
|
4.8
|
15.0
|
1.0
|
|
C
|
A:ASN243
|
4.9
|
11.1
|
1.0
|
|
CB
|
A:YOF7
|
4.9
|
17.4
|
0.7
|
|
ND1
|
A:HIS64
|
4.9
|
25.3
|
1.0
|
|
CG2
|
A:THR199
|
4.9
|
13.9
|
1.0
|
|
CB
|
A:YOF7
|
4.9
|
16.8
|
0.3
|
|
C
|
A:GLY6
|
5.0
|
17.0
|
1.0
|
|
Fluorine binding site 3 out
of 14 in 7u5x
Go back to
Fluorine Binding Sites List in 7u5x
Fluorine binding site 3 out
of 14 in the Crystal Structure Analysis of Human Carbonic Anhydrase 2
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure Analysis of Human Carbonic Anhydrase 2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F40
b:36.5
occ:1.00
|
F
|
A:YOF40
|
0.0
|
36.5
|
1.0
|
|
CE1
|
A:YOF40
|
1.3
|
32.5
|
1.0
|
|
CZ
|
A:YOF40
|
2.4
|
32.3
|
1.0
|
|
CD1
|
A:YOF40
|
2.4
|
29.3
|
1.0
|
|
O
|
A:SER258
|
2.6
|
19.9
|
1.0
|
|
OH
|
A:YOF40
|
2.8
|
33.5
|
1.0
|
|
C
|
A:SER258
|
3.0
|
16.1
|
1.0
|
|
O
|
A:HOH514
|
3.1
|
30.3
|
1.0
|
|
N
|
A:PHE259
|
3.3
|
17.2
|
1.0
|
|
CA
|
A:PHE259
|
3.5
|
19.0
|
1.0
|
|
CE2
|
A:YOF40
|
3.6
|
31.4
|
1.0
|
|
CG
|
A:YOF40
|
3.7
|
27.4
|
1.0
|
|
C
|
A:PHE259
|
3.8
|
23.2
|
1.0
|
|
CA
|
A:SER258
|
4.0
|
14.8
|
1.0
|
|
CD2
|
A:YOF40
|
4.1
|
30.0
|
1.0
|
|
N
|
A:LYS260
|
4.2
|
27.6
|
1.0
|
|
O
|
A:HOH651
|
4.3
|
37.6
|
1.0
|
|
O
|
A:ASP41
|
4.3
|
25.2
|
1.0
|
|
O
|
A:ALA257
|
4.4
|
15.7
|
1.0
|
|
O
|
A:PHE259
|
4.4
|
23.7
|
1.0
|
|
CA
|
A:PRO42
|
4.5
|
28.7
|
1.0
|
|
C
|
A:ASP41
|
4.6
|
24.8
|
1.0
|
|
N
|
A:PRO42
|
4.8
|
27.8
|
1.0
|
|
CB
|
A:PHE259
|
4.9
|
19.4
|
1.0
|
|
CB
|
A:YOF40
|
4.9
|
23.7
|
1.0
|
|
N
|
A:ASP41
|
4.9
|
18.8
|
1.0
|
|
N
|
A:SER258
|
4.9
|
13.8
|
1.0
|
|
Fluorine binding site 4 out
of 14 in 7u5x
Go back to
Fluorine Binding Sites List in 7u5x
Fluorine binding site 4 out
of 14 in the Crystal Structure Analysis of Human Carbonic Anhydrase 2
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure Analysis of Human Carbonic Anhydrase 2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F51
b:15.9
occ:0.70
|
F
|
A:YOF51
|
0.0
|
15.9
|
0.7
|
|
CE2
|
A:YOF51
|
1.3
|
15.1
|
0.3
|
|
CE1
|
A:YOF51
|
1.3
|
15.2
|
0.7
|
|
CZ
|
A:YOF51
|
2.2
|
15.0
|
0.3
|
|
CD1
|
A:YOF51
|
2.3
|
15.9
|
0.7
|
|
CZ
|
A:YOF51
|
2.4
|
15.2
|
0.7
|
|
CD2
|
A:YOF51
|
2.4
|
15.6
|
0.3
|
|
OH
|
A:YOF51
|
2.4
|
15.0
|
0.3
|
|
OH
|
A:YOF51
|
2.9
|
13.7
|
0.7
|
|
NE2
|
A:HIS122
|
3.1
|
12.4
|
1.0
|
|
CD2
|
A:HIS122
|
3.4
|
12.6
|
1.0
|
|
CE1
|
A:YOF51
|
3.5
|
15.3
|
0.3
|
|
N
|
A:VAL78
|
3.6
|
16.5
|
1.0
|
|
C
|
A:ALA77
|
3.6
|
16.8
|
1.0
|
|
C
|
A:VAL78
|
3.6
|
15.2
|
1.0
|
|
CG
|
A:YOF51
|
3.6
|
16.5
|
0.7
|
|
CE2
|
A:YOF51
|
3.6
|
15.1
|
0.7
|
|
CG
|
A:YOF51
|
3.7
|
16.1
|
0.3
|
|
O
|
A:VAL78
|
3.7
|
16.6
|
1.0
|
|
O
|
A:ALA77
|
3.8
|
18.1
|
1.0
|
|
CB
|
A:LEU90
|
3.9
|
12.5
|
1.0
|
|
CA
|
A:VAL78
|
3.9
|
16.3
|
1.0
|
|
N
|
A:LEU79
|
4.0
|
14.4
|
1.0
|
|
CD1
|
A:YOF51
|
4.1
|
16.0
|
0.3
|
|
CD2
|
A:YOF51
|
4.1
|
16.4
|
0.7
|
|
CB
|
A:ALA77
|
4.2
|
18.2
|
1.0
|
|
CA
|
A:ALA77
|
4.3
|
16.7
|
1.0
|
|
CE1
|
A:HIS122
|
4.3
|
12.2
|
1.0
|
|
CD2
|
A:LEU90
|
4.4
|
14.5
|
1.0
|
|
CB
|
A:LEU79
|
4.5
|
16.0
|
1.0
|
|
CG
|
A:LEU90
|
4.6
|
14.2
|
1.0
|
|
F
|
A:YOF51
|
4.6
|
15.8
|
0.3
|
|
CG1
|
A:VAL49
|
4.6
|
22.7
|
1.0
|
|
O
|
A:SER50
|
4.6
|
18.8
|
1.0
|
|
CA
|
A:LEU79
|
4.6
|
14.9
|
1.0
|
|
CG
|
A:HIS122
|
4.7
|
11.8
|
1.0
|
|
N
|
A:LEU90
|
4.7
|
12.0
|
1.0
|
|
CA
|
A:LEU90
|
4.8
|
12.6
|
1.0
|
|
CD1
|
A:LEU90
|
4.8
|
14.6
|
1.0
|
|
CB
|
A:YOF51
|
4.9
|
18.1
|
0.7
|
|
CB
|
A:YOF51
|
5.0
|
17.1
|
0.3
|
|
N
|
A:SER50
|
5.0
|
19.0
|
1.0
|
|
Fluorine binding site 5 out
of 14 in 7u5x
Go back to
Fluorine Binding Sites List in 7u5x
Fluorine binding site 5 out
of 14 in the Crystal Structure Analysis of Human Carbonic Anhydrase 2
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure Analysis of Human Carbonic Anhydrase 2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F51
b:15.8
occ:0.30
|
F
|
A:YOF51
|
0.0
|
15.8
|
0.3
|
|
CE2
|
A:YOF51
|
1.2
|
15.1
|
0.7
|
|
CE1
|
A:YOF51
|
1.3
|
15.3
|
0.3
|
|
CZ
|
A:YOF51
|
2.2
|
15.2
|
0.7
|
|
CD2
|
A:YOF51
|
2.3
|
16.4
|
0.7
|
|
CD1
|
A:YOF51
|
2.4
|
16.0
|
0.3
|
|
CZ
|
A:YOF51
|
2.4
|
15.0
|
0.3
|
|
OH
|
A:YOF51
|
2.6
|
13.7
|
0.7
|
|
OH
|
A:YOF51
|
2.9
|
15.0
|
0.3
|
|
CE1
|
A:YOF51
|
3.5
|
15.2
|
0.7
|
|
CG
|
A:YOF51
|
3.5
|
16.5
|
0.7
|
|
CD2
|
A:LEU120
|
3.6
|
14.4
|
1.0
|
|
CG
|
A:YOF51
|
3.6
|
16.1
|
0.3
|
|
CE2
|
A:YOF51
|
3.7
|
15.1
|
0.3
|
|
CD2
|
A:LEU184
|
3.8
|
16.1
|
1.0
|
|
CB
|
A:PRO180
|
4.0
|
15.6
|
1.0
|
|
CD1
|
A:YOF51
|
4.0
|
15.9
|
0.7
|
|
CD1
|
A:LEU120
|
4.0
|
15.9
|
1.0
|
|
O
|
A:PRO180
|
4.1
|
14.1
|
1.0
|
|
CG1
|
A:VAL49
|
4.1
|
22.7
|
1.0
|
|
CD2
|
A:YOF51
|
4.1
|
15.6
|
0.3
|
|
C
|
A:PRO180
|
4.3
|
14.5
|
1.0
|
|
CD1
|
A:LEU184
|
4.3
|
16.6
|
1.0
|
|
CG
|
A:PRO180
|
4.3
|
16.5
|
1.0
|
|
CG
|
A:LEU184
|
4.4
|
14.9
|
1.0
|
|
CG
|
A:LEU120
|
4.4
|
12.9
|
1.0
|
|
F
|
A:YOF51
|
4.6
|
15.9
|
0.7
|
|
CB
|
A:YOF51
|
4.8
|
18.1
|
0.7
|
|
CA
|
A:PRO180
|
4.8
|
14.4
|
1.0
|
|
N
|
A:ARG181
|
4.8
|
14.8
|
1.0
|
|
CB
|
A:YOF51
|
4.8
|
17.1
|
0.3
|
|
CD2
|
A:LEU143
|
4.9
|
15.8
|
1.0
|
|
CB
|
A:LEU120
|
4.9
|
10.8
|
1.0
|
|
Fluorine binding site 6 out
of 14 in 7u5x
Go back to
Fluorine Binding Sites List in 7u5x
Fluorine binding site 6 out
of 14 in the Crystal Structure Analysis of Human Carbonic Anhydrase 2
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure Analysis of Human Carbonic Anhydrase 2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F88
b:13.4
occ:0.64
|
F
|
A:YOF88
|
0.0
|
13.4
|
0.6
|
|
CE2
|
A:YOF88
|
1.3
|
14.1
|
0.4
|
|
CE1
|
A:YOF88
|
1.3
|
11.4
|
0.6
|
|
CZ
|
A:YOF88
|
2.1
|
13.6
|
0.4
|
|
CZ
|
A:YOF88
|
2.4
|
11.1
|
0.6
|
|
CD1
|
A:YOF88
|
2.4
|
11.4
|
0.6
|
|
OH
|
A:YOF88
|
2.4
|
12.3
|
0.4
|
|
CD2
|
A:YOF88
|
2.5
|
13.3
|
0.4
|
|
OH
|
A:YOF88
|
2.8
|
11.7
|
0.6
|
|
N
|
A:GLY86
|
3.0
|
18.9
|
1.0
|
|
O
|
A:HOH427
|
3.2
|
18.9
|
1.0
|
|
CA
|
A:GLY86
|
3.3
|
18.9
|
1.0
|
|
C
|
A:GLY86
|
3.4
|
17.4
|
1.0
|
|
CB
|
A:LEU84
|
3.4
|
15.1
|
1.0
|
|
O
|
A:GLY86
|
3.4
|
17.8
|
1.0
|
|
CE1
|
A:YOF88
|
3.4
|
14.0
|
0.4
|
|
CE2
|
A:YOF88
|
3.6
|
11.1
|
0.6
|
|
CG
|
A:YOF88
|
3.6
|
12.0
|
0.6
|
|
CG
|
A:YOF88
|
3.6
|
12.9
|
0.4
|
|
N
|
A:ASP85
|
3.7
|
17.5
|
1.0
|
|
ND2
|
A:ASN124
|
3.8
|
14.6
|
1.0
|
|
CD2
|
A:LEU84
|
4.0
|
13.7
|
1.0
|
|
CD1
|
A:YOF88
|
4.0
|
13.4
|
0.4
|
|
CA
|
A:LEU84
|
4.1
|
15.6
|
1.0
|
|
C
|
A:ASP85
|
4.1
|
20.0
|
1.0
|
|
N
|
A:THR87
|
4.1
|
15.7
|
1.0
|
|
CG
|
A:LEU84
|
4.1
|
14.1
|
1.0
|
|
O
|
A:HOH411
|
4.1
|
24.8
|
1.0
|
|
CD2
|
A:YOF88
|
4.1
|
11.2
|
0.6
|
|
C
|
A:LEU84
|
4.2
|
17.5
|
1.0
|
|
OD2
|
A:ASP85
|
4.2
|
32.7
|
1.0
|
|
CD1
|
A:LEU84
|
4.3
|
14.8
|
1.0
|
|
CG
|
A:ASN124
|
4.4
|
13.1
|
1.0
|
|
CA
|
A:ASP85
|
4.5
|
20.1
|
1.0
|
|
F
|
A:YOF88
|
4.5
|
16.8
|
0.4
|
|
C
|
A:THR87
|
4.8
|
13.7
|
1.0
|
|
OD1
|
A:ASN124
|
4.8
|
13.2
|
1.0
|
|
CA
|
A:THR87
|
4.9
|
15.2
|
1.0
|
|
CB
|
A:YOF88
|
4.9
|
13.3
|
0.6
|
|
CB
|
A:YOF88
|
4.9
|
12.9
|
0.4
|
|
O
|
A:THR87
|
5.0
|
14.7
|
1.0
|
|
N
|
A:YOF88
|
5.0
|
13.5
|
0.6
|
|
Fluorine binding site 7 out
of 14 in 7u5x
Go back to
Fluorine Binding Sites List in 7u5x
Fluorine binding site 7 out
of 14 in the Crystal Structure Analysis of Human Carbonic Anhydrase 2
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Crystal Structure Analysis of Human Carbonic Anhydrase 2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F88
b:16.8
occ:0.36
|
F
|
A:YOF88
|
0.0
|
16.8
|
0.4
|
|
CE2
|
A:YOF88
|
1.1
|
11.1
|
0.6
|
|
CE1
|
A:YOF88
|
1.4
|
14.0
|
0.4
|
|
CZ
|
A:YOF88
|
2.2
|
11.1
|
0.6
|
|
CD2
|
A:YOF88
|
2.2
|
11.2
|
0.6
|
|
CD1
|
A:YOF88
|
2.4
|
13.4
|
0.4
|
|
CZ
|
A:YOF88
|
2.4
|
13.6
|
0.4
|
|
OH
|
A:YOF88
|
2.6
|
11.7
|
0.6
|
|
OH
|
A:YOF88
|
2.9
|
12.3
|
0.4
|
|
C
|
A:LEU140
|
2.9
|
10.1
|
1.0
|
|
C
|
A:GLY139
|
2.9
|
11.5
|
1.0
|
|
N
|
A:LEU140
|
2.9
|
10.8
|
1.0
|
|
O
|
A:ASP138
|
3.0
|
12.8
|
1.0
|
|
O
|
A:HOH439
|
3.0
|
13.1
|
1.0
|
|
O
|
A:GLY139
|
3.0
|
11.6
|
1.0
|
|
O
|
A:LEU140
|
3.1
|
10.8
|
1.0
|
|
CA
|
A:LEU140
|
3.1
|
10.6
|
1.0
|
|
CE1
|
A:YOF88
|
3.4
|
11.4
|
0.6
|
|
N
|
A:ALA141
|
3.4
|
10.1
|
1.0
|
|
CG
|
A:YOF88
|
3.4
|
12.0
|
0.6
|
|
CB
|
A:ASN124
|
3.5
|
12.7
|
1.0
|
|
CG
|
A:YOF88
|
3.6
|
12.9
|
0.4
|
|
C
|
A:ASP138
|
3.7
|
11.8
|
1.0
|
|
CE2
|
A:YOF88
|
3.7
|
14.1
|
0.4
|
|
CA
|
A:GLY139
|
3.9
|
11.2
|
1.0
|
|
N
|
A:ASN124
|
3.9
|
11.3
|
1.0
|
|
CD1
|
A:YOF88
|
3.9
|
11.4
|
0.6
|
|
N
|
A:GLY139
|
4.0
|
11.6
|
1.0
|
|
ND2
|
A:ASN124
|
4.1
|
14.6
|
1.0
|
|
CA
|
A:ASN124
|
4.1
|
12.2
|
1.0
|
|
CD2
|
A:YOF88
|
4.1
|
13.3
|
0.4
|
|
CG
|
A:ASN124
|
4.3
|
13.1
|
1.0
|
|
CB
|
A:ALA141
|
4.3
|
11.2
|
1.0
|
|
CA
|
A:ALA141
|
4.3
|
10.9
|
1.0
|
|
F
|
A:YOF88
|
4.5
|
13.4
|
0.6
|
|
C
|
A:TRP123
|
4.6
|
10.8
|
1.0
|
|
O
|
A:HIS122
|
4.6
|
11.3
|
1.0
|
|
CB
|
A:LEU140
|
4.7
|
11.5
|
1.0
|
|
CB
|
A:YOF88
|
4.7
|
13.3
|
0.6
|
|
CA
|
A:ASP138
|
4.7
|
12.3
|
1.0
|
|
CA
|
A:TRP123
|
4.8
|
11.0
|
1.0
|
|
CB
|
A:YOF88
|
4.8
|
12.9
|
0.4
|
|
Fluorine binding site 8 out
of 14 in 7u5x
Go back to
Fluorine Binding Sites List in 7u5x
Fluorine binding site 8 out
of 14 in the Crystal Structure Analysis of Human Carbonic Anhydrase 2
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Crystal Structure Analysis of Human Carbonic Anhydrase 2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F114
b:18.4
occ:0.51
|
F
|
A:YOF114
|
0.0
|
18.4
|
0.5
|
|
CE2
|
A:YOF114
|
1.3
|
12.7
|
0.5
|
|
CE1
|
A:YOF114
|
1.3
|
14.8
|
0.5
|
|
CZ
|
A:YOF114
|
2.2
|
14.9
|
0.5
|
|
CD1
|
A:YOF114
|
2.4
|
12.3
|
0.5
|
|
CZ
|
A:YOF114
|
2.4
|
15.4
|
0.5
|
|
CD2
|
A:YOF114
|
2.4
|
11.9
|
0.5
|
|
OH
|
A:YOF114
|
2.5
|
18.0
|
0.5
|
|
OH
|
A:YOF114
|
2.9
|
18.8
|
0.5
|
|
CG2
|
A:VAL109
|
3.2
|
13.9
|
1.0
|
|
CB
|
A:VAL109
|
3.3
|
13.7
|
1.0
|
|
CE1
|
A:YOF114
|
3.5
|
14.7
|
0.5
|
|
O
|
A:HOH572
|
3.6
|
31.3
|
1.0
|
|
CG
|
A:YOF114
|
3.6
|
11.1
|
0.5
|
|
CG
|
A:YOF114
|
3.6
|
11.5
|
0.5
|
|
CE2
|
A:YOF114
|
3.7
|
14.1
|
0.5
|
|
O
|
A:HOH501
|
3.7
|
21.5
|
1.0
|
|
CD
|
A:LYS112
|
3.8
|
17.1
|
1.0
|
|
CD1
|
A:YOF114
|
4.0
|
12.5
|
0.5
|
|
CD2
|
A:PHE146
|
4.1
|
11.4
|
1.0
|
|
CD2
|
A:YOF114
|
4.1
|
12.1
|
0.5
|
|
CE2
|
A:PHE146
|
4.1
|
11.6
|
1.0
|
|
CG
|
A:LYS112
|
4.2
|
15.5
|
1.0
|
|
O
|
A:LYS112
|
4.2
|
13.0
|
1.0
|
|
CE
|
A:LYS112
|
4.2
|
19.8
|
1.0
|
|
N
|
A:VAL109
|
4.2
|
11.7
|
1.0
|
|
CG1
|
A:VAL109
|
4.3
|
14.2
|
1.0
|
|
CG
|
A:PHE146
|
4.3
|
10.2
|
1.0
|
|
CB
|
A:LYS112
|
4.4
|
13.9
|
1.0
|
|
CA
|
A:VAL109
|
4.4
|
12.2
|
1.0
|
|
CZ
|
A:PHE146
|
4.4
|
11.0
|
1.0
|
|
CD1
|
A:PHE146
|
4.6
|
10.1
|
1.0
|
|
F
|
A:YOF114
|
4.6
|
16.8
|
0.5
|
|
CE1
|
A:PHE146
|
4.7
|
11.2
|
1.0
|
|
O
|
A:HOH531
|
4.8
|
18.4
|
1.0
|
|
O
|
A:VAL109
|
4.8
|
13.0
|
1.0
|
|
C
|
A:LYS112
|
4.9
|
12.4
|
1.0
|
|
CB
|
A:YOF114
|
4.9
|
11.3
|
0.5
|
|
CB
|
A:YOF114
|
4.9
|
11.3
|
0.5
|
|
CB
|
A:PHE146
|
5.0
|
10.6
|
1.0
|
|
Fluorine binding site 9 out
of 14 in 7u5x
Go back to
Fluorine Binding Sites List in 7u5x
Fluorine binding site 9 out
of 14 in the Crystal Structure Analysis of Human Carbonic Anhydrase 2
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 9 of Crystal Structure Analysis of Human Carbonic Anhydrase 2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F114
b:16.8
occ:0.49
|
F
|
A:YOF114
|
0.0
|
16.8
|
0.5
|
|
CE2
|
A:YOF114
|
1.2
|
14.1
|
0.5
|
|
CE1
|
A:YOF114
|
1.4
|
14.7
|
0.5
|
|
CD2
|
A:YOF114
|
2.2
|
12.1
|
0.5
|
|
CZ
|
A:YOF114
|
2.2
|
15.4
|
0.5
|
|
CD1
|
A:YOF114
|
2.3
|
12.5
|
0.5
|
|
CZ
|
A:YOF114
|
2.4
|
14.9
|
0.5
|
|
OH
|
A:YOF114
|
2.6
|
18.8
|
0.5
|
|
O
|
A:HOH424
|
2.8
|
28.9
|
1.0
|
|
OH
|
A:YOF114
|
3.0
|
18.0
|
0.5
|
|
CG
|
A:PRO214
|
3.1
|
19.3
|
1.0
|
|
O
|
A:HOH686
|
3.2
|
29.3
|
1.0
|
|
CE1
|
A:YOF114
|
3.5
|
14.8
|
0.5
|
|
CB
|
A:PRO214
|
3.5
|
13.3
|
1.0
|
|
CG
|
A:YOF114
|
3.5
|
11.5
|
0.5
|
|
O
|
A:HOH534
|
3.6
|
20.2
|
1.0
|
|
CG
|
A:YOF114
|
3.6
|
11.1
|
0.5
|
|
CE2
|
A:YOF114
|
3.7
|
12.7
|
0.5
|
|
CD
|
A:LYS148
|
3.7
|
22.4
|
1.0
|
|
CE
|
A:LYS112
|
3.8
|
19.8
|
1.0
|
|
CB
|
A:LYS148
|
3.8
|
15.4
|
1.0
|
|
CD1
|
A:YOF114
|
4.0
|
12.3
|
0.5
|
|
CG
|
A:LYS148
|
4.1
|
17.3
|
1.0
|
|
CD2
|
A:YOF114
|
4.1
|
11.9
|
0.5
|
|
O
|
A:HOH614
|
4.4
|
45.5
|
1.0
|
|
CD
|
A:PRO214
|
4.4
|
15.2
|
1.0
|
|
O
|
A:HOH662
|
4.6
|
15.8
|
1.0
|
|
NZ
|
A:LYS112
|
4.6
|
21.8
|
1.0
|
|
F
|
A:YOF114
|
4.6
|
18.4
|
0.5
|
|
CB
|
A:YOF114
|
4.7
|
11.3
|
0.5
|
|
CE
|
A:LYS148
|
4.8
|
26.0
|
1.0
|
|
CA
|
A:LYS148
|
4.8
|
13.0
|
1.0
|
|
CB
|
A:YOF114
|
4.8
|
11.3
|
0.5
|
|
CD
|
A:LYS112
|
4.8
|
17.1
|
1.0
|
|
N
|
A:LYS148
|
4.9
|
11.8
|
1.0
|
|
Fluorine binding site 10 out
of 14 in 7u5x
Go back to
Fluorine Binding Sites List in 7u5x
Fluorine binding site 10 out
of 14 in the Crystal Structure Analysis of Human Carbonic Anhydrase 2
 Mono view
 Stereo pair view
|
|
A full contact list of Fluorine with other atoms in the F binding
site number 10 of Crystal Structure Analysis of Human Carbonic Anhydrase 2 within 5.0Å range:
|
probe
|
atom
|
residue
|
distance (Å)
|
B
|
Occ
|
A:F127
b:21.4
occ:1.00
|
F
|
A:YOF127
|
0.0
|
21.4
|
1.0
|
|
CE1
|
A:YOF127
|
1.3
|
17.0
|
1.0
|
|
CZ
|
A:YOF127
|
2.3
|
16.3
|
1.0
|
|
CD1
|
A:YOF127
|
2.4
|
16.1
|
1.0
|
|
OH
|
A:YOF127
|
2.6
|
17.9
|
1.0
|
|
O
|
A:HOH544
|
2.9
|
39.3
|
1.0
|
|
O
|
A:HOH726
|
3.2
|
36.5
|
1.0
|
|
CE2
|
A:YOF127
|
3.6
|
15.2
|
1.0
|
|
O
|
A:HOH606
|
3.6
|
20.6
|
1.0
|
|
CG
|
A:YOF127
|
3.6
|
13.8
|
1.0
|
|
CD
|
A:GLN136
|
4.0
|
20.2
|
1.0
|
|
CD2
|
A:YOF127
|
4.0
|
13.8
|
1.0
|
|
OE1
|
A:GLN136
|
4.1
|
23.9
|
1.0
|
|
CG
|
A:GLN136
|
4.2
|
18.2
|
1.0
|
|
CE
|
A:LYS126
|
4.3
|
22.3
|
1.0
|
|
NE2
|
A:GLN136
|
4.4
|
23.4
|
1.0
|
|
CG
|
A:LYS126
|
4.6
|
18.0
|
1.0
|
|
CB
|
A:GLN136
|
4.9
|
14.8
|
1.0
|
|
CD
|
A:LYS126
|
4.9
|
20.3
|
1.0
|
|
CB
|
A:YOF127
|
4.9
|
14.7
|
1.0
|
|
O
|
A:LYS126
|
4.9
|
16.4
|
1.0
|
|
Reference:
H.-S.Seo,
S.Dhe-Paganon.
Crystal Structure Analysis of Human Carbonic Anhydrase 2 To Be Published.
Page generated: Fri Aug 2 13:56:31 2024
|
