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Fluorine in PDB 7u9a: Egfr in Complex with A Macrocyclic InhibitorEnzymatic activity of Egfr in Complex with A Macrocyclic Inhibitor
All present enzymatic activity of Egfr in Complex with A Macrocyclic Inhibitor:
2.7.10.1; Protein crystallography data
The structure of Egfr in Complex with A Macrocyclic Inhibitor, PDB code: 7u9a
was solved by
T.S.Beyett,
M.J.Eck,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7u9a:
The structure of Egfr in Complex with A Macrocyclic Inhibitor also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Egfr in Complex with A Macrocyclic Inhibitor
(pdb code 7u9a). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Egfr in Complex with A Macrocyclic Inhibitor, PDB code: 7u9a: Fluorine binding site 1 out of 1 in 7u9aGo back to Fluorine Binding Sites List in 7u9a
Fluorine binding site 1 out
of 1 in the Egfr in Complex with A Macrocyclic Inhibitor
Mono view Stereo pair view
Reference:
J.A.Amrhein,
T.S.Beyett,
W.W.Feng,
A.Kramer,
J.Weckesser,
I.K.Schaeffner,
J.K.Rana,
P.A.Janne,
M.J.Eck,
S.Knapp,
T.Hanke.
Macrocyclization of Quinazoline-Based Egfr Inhibitors Leads to Exclusive Mutant Selectivity For Egfr L858R and DEL19. J.Med.Chem. V. 65 15679 2022.
Page generated: Fri Aug 2 13:57:15 2024
ISSN: ISSN 0022-2623 PubMed: 36384036 DOI: 10.1021/ACS.JMEDCHEM.2C01041 |
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