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Fluorine in PDB 7uyr: Crystal Structure of TYK2 Kinase Domain in Complex with Compound 12Enzymatic activity of Crystal Structure of TYK2 Kinase Domain in Complex with Compound 12
All present enzymatic activity of Crystal Structure of TYK2 Kinase Domain in Complex with Compound 12:
2.7.10.2; Protein crystallography data
The structure of Crystal Structure of TYK2 Kinase Domain in Complex with Compound 12, PDB code: 7uyr
was solved by
A.V.Toms,
S.Leit,
J.R.Greenwood,
S.Mondal,
S.Carriero,
M.Dahlgren,
G.C.Harriman,
J.J.Kennedy-Smith,
R.Kapeller,
J.P.Lawson,
D.L.Romero,
M.Shelley,
R.T.Wester,
W.Westlin,
J.J.Mc Elwee,
W.Miao,
S.D.Edmondson,
C.E.Massee,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of TYK2 Kinase Domain in Complex with Compound 12
(pdb code 7uyr). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of TYK2 Kinase Domain in Complex with Compound 12, PDB code: 7uyr: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 7uyrGo back to Fluorine Binding Sites List in 7uyr
Fluorine binding site 1 out
of 2 in the Crystal Structure of TYK2 Kinase Domain in Complex with Compound 12
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 7uyrGo back to Fluorine Binding Sites List in 7uyr
Fluorine binding site 2 out
of 2 in the Crystal Structure of TYK2 Kinase Domain in Complex with Compound 12
Mono view Stereo pair view
Reference:
S.Leit,
J.R.Greenwood,
S.Mondal,
S.Carriero,
M.Dahlgren,
G.C.Harriman,
J.J.Kennedy-Smith,
R.Kapeller,
J.P.Lawson,
D.L.Romero,
A.V.Toms,
M.Shelley,
R.T.Wester,
W.Westlin,
J.J.Mcelwee,
W.Miao,
S.D.Edmondson,
C.E.Masse.
Potent and Selective TYK2-JH1 Inhibitors Highly Efficacious in Rodent Model of Psoriasis. Bioorg.Med.Chem.Lett. V. 73 28891 2022.
Page generated: Wed Apr 5 01:30:23 2023
ISSN: ESSN 1464-3405 PubMed: 35842205 DOI: 10.1016/J.BMCL.2022.128891 |
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