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Fluorine in PDB 7v10: Factor Xia in Complex with Compound 2DEnzymatic activity of Factor Xia in Complex with Compound 2D
All present enzymatic activity of Factor Xia in Complex with Compound 2D:
3.4.21.27; Protein crystallography data
The structure of Factor Xia in Complex with Compound 2D, PDB code: 7v10
was solved by
P.L.Shaffer,
J.Spurlino,
C.M.Milligan,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 7v10:
The structure of Factor Xia in Complex with Compound 2D also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Factor Xia in Complex with Compound 2D
(pdb code 7v10). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Factor Xia in Complex with Compound 2D, PDB code: 7v10: Fluorine binding site 1 out of 1 in 7v10Go back to Fluorine Binding Sites List in 7v10
Fluorine binding site 1 out
of 1 in the Factor Xia in Complex with Compound 2D
Mono view Stereo pair view
Reference:
G.Xu,
Z.Liu,
X.Wang,
T.Lu,
R.L.Desjarlais,
T.Thieu,
J.Zhang,
Z.H.Devine,
F.Du,
Q.Li,
C.M.Milligan,
P.Shaffer,
P.E.Cedervall,
J.C.Spurlino,
C.F.Stratton,
B.Pietrak,
L.M.Szewczuk,
V.Wong,
R.A.Steele,
W.Bruinzeel,
M.Chintala,
J.Silva,
M.D.Gaul,
M.J.Macielag,
R.Nargund.
Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor Xia Inhibitors Through Exploiting Nonclassical Interactions. J.Med.Chem. V. 65 10419 2022.
Page generated: Fri Aug 2 14:21:34 2024
ISSN: ISSN 0022-2623 PubMed: 35862732 DOI: 10.1021/ACS.JMEDCHEM.2C00442 |
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