Fluorine in PDB 7vc5: Toxoplasma Gondii Prolyl-Trna Synthetase (Tgprs) in Complex with Inhibitor T35 and Febrifugine (Ff) at 1.61 A Resolution

The structure of Toxoplasma Gondii Prolyl-Trna Synthetase (Tgprs) in Complex with Inhibitor T35 and Febrifugine (Ff) at 1.61 A Resolution, PDB code: 7vc5 was solved by Y.Manickam, N.Malhotra, A.Sharma, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	53.56 / 1.61
Space group	C 1 2 1
Cell size a, b, c (Å), α, β, γ (°)	115.194, 73.092, 74.936, 90, 111.57, 90
R / Rfree (%)	16.5 / 19.6

The structure of Toxoplasma Gondii Prolyl-Trna Synthetase (Tgprs) in Complex with Inhibitor T35 and Febrifugine (Ff) at 1.61 A Resolution also contains other interesting chemical elements:

Chlorine

(Cl)

2 atoms

The binding sites of Fluorine atom in the Toxoplasma Gondii Prolyl-Trna Synthetase (Tgprs) in Complex with Inhibitor T35 and Febrifugine (Ff) at 1.61 A Resolution (pdb code 7vc5). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Toxoplasma Gondii Prolyl-Trna Synthetase (Tgprs) in Complex with Inhibitor T35 and Febrifugine (Ff) at 1.61 A Resolution, PDB code: 7vc5:

Fluorine binding site 1 out of 1 in the Toxoplasma Gondii Prolyl-Trna Synthetase (Tgprs) in Complex with Inhibitor T35 and Febrifugine (Ff) at 1.61 A Resolution


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Toxoplasma Gondii Prolyl-Trna Synthetase (Tgprs) in Complex with Inhibitor T35 and Febrifugine (Ff) at 1.61 A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:F901 b:37.0 occ:0.94 F A:1TI901 0.0 37.0 0.9 C10 A:1TI901 1.4 32.8 0.9 C9 A:1TI901 2.3 29.7 0.9 C11 A:1TI901 2.4 33.1 0.9 CB A:PRO476 3.2 36.8 1.0 O A:LYS474 3.3 44.6 1.0 O A:HOH1007 3.3 53.8 1.0 CA A:PRO476 3.4 34.5 1.0 C8 A:1TI901 3.6 30.8 0.9 C12 A:1TI901 3.6 30.1 0.9 N A:PRO476 3.7 32.8 1.0 CG A:ARG483 3.8 37.3 1.0 CD A:PRO476 4.0 41.1 1.0 O A:ARG481 4.0 31.6 1.0 O A:GLU472 4.0 50.7 1.0 CG A:PRO476 4.1 41.1 1.0 C13 A:1TI901 4.1 30.7 0.9 C A:GLN475 4.2 37.5 1.0 NE A:ARG483 4.2 61.9 1.0 N A:ARG483 4.3 28.6 1.0 C A:LYS474 4.3 46.4 1.0 CA A:GLY363 4.4 40.7 1.0 CA A:THR482 4.5 32.1 1.0 C A:THR482 4.5 30.8 1.0 O A:GLN475 4.5 37.8 1.0 CD A:ARG483 4.6 49.4 1.0 C A:ARG481 4.6 31.3 1.0 N A:THR482 4.8 30.2 1.0 C14 A:1TI901 4.8 33.9 0.9 C7 A:1TI901 4.9 28.8 0.9 CB A:ARG483 4.9 34.2 1.0 CB A:GLU472 4.9 47.3 0.8 C A:GLU472 4.9 50.1 1.0 C A:PRO476 4.9 35.5 1.0 CA A:ARG483 4.9 30.3 1.0 CB A:GLU472 4.9 49.9 0.1

N.Malhotra, Y.Manickam, A.Sharma. Tgprs with Double Inhibitors To Be Published.