Fluorine in PDB 7wcn: Cryo-Em Structure of GPR119-Gs Complex with Small Molecule Agonist AR231453

The binding sites of Fluorine atom in the Cryo-Em Structure of GPR119-Gs Complex with Small Molecule Agonist AR231453 (pdb code 7wcn). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Cryo-Em Structure of GPR119-Gs Complex with Small Molecule Agonist AR231453, PDB code: 7wcn:

Fluorine binding site 1 out of 1 in the Cryo-Em Structure of GPR119-Gs Complex with Small Molecule Agonist AR231453


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of GPR119-Gs Complex with Small Molecule Agonist AR231453 within 5.0Å range: probe atom residue distance (Å) B Occ R:F401 b:58.0 occ:1.00 F28 R:8WL401 0.0 58.0 1.0 C27 R:8WL401 1.4 58.0 1.0 C26 R:8WL401 2.4 58.0 1.0 C18 R:8WL401 2.4 58.0 1.0 N15 R:8WL401 2.7 58.0 1.0 N17 R:8WL401 2.9 58.0 1.0 C16 R:8WL401 3.0 58.0 1.0 CD2 R:PHE157 3.3 69.4 1.0 CZ R:PHE241 3.5 56.0 1.0 CD1 R:TRP265 3.6 58.1 1.0 CE2 R:PHE157 3.6 69.4 1.0 C21 R:8WL401 3.6 58.0 1.0 C19 R:8WL401 3.6 58.0 1.0 CE1 R:PHE241 3.6 56.0 1.0 C14 R:8WL401 3.7 58.0 1.0 CG R:PHE157 3.9 69.4 1.0 NE1 R:TRP265 3.9 58.1 1.0 OE1 R:GLU261 4.0 66.6 1.0 C20 R:8WL401 4.1 58.0 1.0 C29 R:8WL401 4.2 58.0 1.0 CG R:TRP265 4.4 58.1 1.0 CB R:PHE157 4.4 69.4 1.0 CZ R:PHE157 4.4 69.4 1.0 CE2 R:PHE241 4.6 56.0 1.0 CD1 R:PHE157 4.6 69.4 1.0 N13 R:8WL401 4.7 58.0 1.0 O R:LEU260 4.8 66.5 1.0 CD1 R:PHE241 4.9 56.0 1.0 CE1 R:PHE157 4.9 69.4 1.0 CE2 R:TRP265 4.9 58.1 1.0 CB R:TRP265 5.0 58.1 1.0 C12 R:8WL401 5.0 58.0 1.0

Y.Qian, J.Wang, L.Yang, Y.Liu, L.Wang, W.Liu, Y.Lin, H.Yang, L.Ma, S.Ye, S.Wu, A.Qiao. Activation and Signaling Mechanism Revealed By GPR119-G S Complex Structures. Nat Commun V. 13 7033 2022.
ISSN: ESSN 2041-1723
PubMed: 36396650
DOI: 10.1038/S41467-022-34696-6