Fluorine in PDB 7wl4: Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50
Protein crystallography data
The structure of Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50, PDB code: 7wl4
was solved by
C.Zhang,
C.Wang,
W.Li,
Y.Zhang,
Y.Xu,
L.Sun,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 107.31 / 1.82 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 59.858, 42.484, 107.309, 90, 90, 90 |
| R / Rfree (%) | 18.4 / 22.1 |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50
(pdb code 7wl4). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 8 binding sites of Fluorine where determined in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50, PDB code: 7wl4:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
In total 8 binding sites of Fluorine where determined in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50, PDB code: 7wl4:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8;
Fluorine binding site 1 out of 8 in 7wl4
Go back to
Fluorine Binding Sites List in 7wl4
Fluorine binding site 1 out
of 8 in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50 within 5.0Å range:
|
Fluorine binding site 2 out of 8 in 7wl4
Go back to
Fluorine Binding Sites List in 7wl4
Fluorine binding site 2 out
of 8 in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50 within 5.0Å range:
|
Fluorine binding site 3 out of 8 in 7wl4
Go back to
Fluorine Binding Sites List in 7wl4
Fluorine binding site 3 out
of 8 in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50 within 5.0Å range:
|
Fluorine binding site 4 out of 8 in 7wl4
Go back to
Fluorine Binding Sites List in 7wl4
Fluorine binding site 4 out
of 8 in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 4 of Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50 within 5.0Å range:
|
Fluorine binding site 5 out of 8 in 7wl4
Go back to
Fluorine Binding Sites List in 7wl4
Fluorine binding site 5 out
of 8 in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 5 of Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50 within 5.0Å range:
|
Fluorine binding site 6 out of 8 in 7wl4
Go back to
Fluorine Binding Sites List in 7wl4
Fluorine binding site 6 out
of 8 in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 6 of Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50 within 5.0Å range:
|
Fluorine binding site 7 out of 8 in 7wl4
Go back to
Fluorine Binding Sites List in 7wl4
Fluorine binding site 7 out
of 8 in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 7 of Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50 within 5.0Å range:
|
Fluorine binding site 8 out of 8 in 7wl4
Go back to
Fluorine Binding Sites List in 7wl4
Fluorine binding site 8 out
of 8 in the Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 8 of Crystal Structure of the First Bromodomain of Human BRD4 in Complex with the Inhibitor Slp-50 within 5.0Å range:
|
Reference:
W.Li,
C.Zhang,
H.E.Zhang,
R.Dong,
J.Y.Liu,
C.M.Wang,
M.Wang,
Y.W.Wang,
C.Wang,
Y.Zhang,
L.Shi,
Y.Xu,
L.P.Sun.
Design, Synthesis, and Anticancer Evaluation of Ammosamide B with Pyrroloquinoline Derivatives As Novel BRD4 Inhibitors. Bioorg.Chem. V. 127 05917 2022.
ISSN: ISSN 0045-2068
PubMed: 35738217
DOI: 10.1016/J.BIOORG.2022.105917
Page generated: Fri Aug 2 14:50:25 2024
ISSN: ISSN 0045-2068
PubMed: 35738217
DOI: 10.1016/J.BIOORG.2022.105917
Last articles
Zn in 9JYWZn in 9IR4
Zn in 9IR3
Zn in 9GMX
Zn in 9GMW
Zn in 9JEJ
Zn in 9ERF
Zn in 9ERE
Zn in 9EGV
Zn in 9EGW
