Fluorine in PDB 7wll: Cryoem Structure of Human Low-Voltage Activated T-Type Calcium Channel CAV3.3 in Complex with Pimozide(Pmz)

The structure of Cryoem Structure of Human Low-Voltage Activated T-Type Calcium Channel CAV3.3 in Complex with Pimozide(Pmz) also contains other interesting chemical elements:

Calcium

(Ca)

2 atoms

The binding sites of Fluorine atom in the Cryoem Structure of Human Low-Voltage Activated T-Type Calcium Channel CAV3.3 in Complex with Pimozide(Pmz) (pdb code 7wll). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Cryoem Structure of Human Low-Voltage Activated T-Type Calcium Channel CAV3.3 in Complex with Pimozide(Pmz), PDB code: 7wll:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Cryoem Structure of Human Low-Voltage Activated T-Type Calcium Channel CAV3.3 in Complex with Pimozide(Pmz)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryoem Structure of Human Low-Voltage Activated T-Type Calcium Channel CAV3.3 in Complex with Pimozide(Pmz) within 5.0Å range: probe atom residue distance (Å) B Occ A:F2301 b:59.0 occ:1.00 F01 A:1II2301 0.0 59.0 1.0 C33 A:1II2301 1.4 59.0 1.0 C29 A:1II2301 2.4 59.0 1.0 C31 A:1II2301 2.4 59.0 1.0 CD2 A:PHE1426 3.2 59.1 1.0 CA A:LEU1423 3.2 57.0 1.0 CB A:PHE1426 3.3 59.1 1.0 O A:LEU1423 3.3 57.0 1.0 CG2 A:VAL858 3.5 59.1 1.0 CD2 A:LEU1423 3.5 57.0 1.0 CG A:PHE1426 3.6 59.1 1.0 CB A:LEU1423 3.6 57.0 1.0 C25 A:1II2301 3.6 59.0 1.0 C27 A:1II2301 3.6 59.0 1.0 C A:LEU1423 3.7 57.0 1.0 C20 A:1II2301 4.1 59.0 1.0 CG A:LEU1423 4.2 57.0 1.0 CE2 A:PHE1426 4.2 59.1 1.0 N A:LEU1423 4.3 57.0 1.0 O A:VAL1422 4.4 54.6 1.0 CA A:PHE1426 4.6 59.1 1.0 CG1 A:VAL858 4.6 59.1 1.0 CB A:VAL858 4.6 59.1 1.0 CD1 A:PHE1426 4.7 59.1 1.0 C A:VAL1422 4.7 54.6 1.0 N A:VAL1427 4.8 63.4 1.0 N A:PHE1426 4.8 59.1 1.0 CZ A:PHE854 4.8 56.8 0.5 CG2 A:VAL1427 4.9 63.4 1.0

Fluorine binding site 2 out of 2 in the Cryoem Structure of Human Low-Voltage Activated T-Type Calcium Channel CAV3.3 in Complex with Pimozide(Pmz)


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryoem Structure of Human Low-Voltage Activated T-Type Calcium Channel CAV3.3 in Complex with Pimozide(Pmz) within 5.0Å range: probe atom residue distance (Å) B Occ A:F2301 b:59.0 occ:1.00 F02 A:1II2301 0.0 59.0 1.0 C34 A:1II2301 1.4 59.0 1.0 C30 A:1II2301 2.4 59.0 1.0 C32 A:1II2301 2.4 59.0 1.0 C A:LEU1721 2.9 55.4 1.0 N A:ILE1722 2.9 57.8 1.0 O A:LEU1721 3.1 55.4 1.0 CB A:LEU1721 3.1 55.4 1.0 CA A:ILE1722 3.3 57.8 1.0 CA A:LEU1721 3.6 55.4 1.0 C28 A:1II2301 3.6 59.0 1.0 C26 A:1II2301 3.6 59.0 1.0 CG1 A:ILE1722 3.7 57.8 1.0 CG2 A:VAL1725 3.8 62.6 1.0 CE1 A:PHE387 4.0 57.8 1.0 C21 A:1II2301 4.1 59.0 1.0 CB A:ILE1722 4.1 57.8 1.0 O A:GLN1718 4.2 54.3 1.0 CZ A:PHE387 4.3 57.8 1.0 C A:ILE1722 4.5 57.8 1.0 CG A:LEU1721 4.5 55.4 1.0 CB A:VAL1725 4.5 62.6 1.0 ND2 A:ASN391 4.6 63.1 1.0 N A:LEU1721 4.7 55.4 1.0 CD1 A:LEU1721 4.7 55.4 1.0 NE2 A:GLN1718 4.8 54.3 1.0 O A:ILE1722 5.0 57.8 1.0

L.He, Z.Yu, Z.Geng, Z.Huang, C.Zhang, Y.Dong, Y.Gao, Y.Wang, Q.Chen, L.Sun, X.Ma, B.Huang, X.Wang, Y.Zhao. Structure, Gating, and Pharmacology of Human Ca V 3.3 Channel. Nat Commun V. 13 2084 2022.
ISSN: ESSN 2041-1723
PubMed: 35440630
DOI: 10.1038/S41467-022-29728-0