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Fluorine in PDB 7wln: Crystal Structure of the Second Bromodomain of Human BRD2 in Complex with the Inhibitor Y13153Protein crystallography data
The structure of Crystal Structure of the Second Bromodomain of Human BRD2 in Complex with the Inhibitor Y13153, PDB code: 7wln
was solved by
J.Li,
C.Zhang,
H.Xu,
X.Zhuang,
X.Wu,
Y.Zhang,
Y.Xu,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of the Second Bromodomain of Human BRD2 in Complex with the Inhibitor Y13153
(pdb code 7wln). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 4 binding sites of Fluorine where determined in the Crystal Structure of the Second Bromodomain of Human BRD2 in Complex with the Inhibitor Y13153, PDB code: 7wln: Jump to Fluorine binding site number: 1; 2; 3; 4; Fluorine binding site 1 out of 4 in 7wlnGo back to Fluorine Binding Sites List in 7wln
Fluorine binding site 1 out
of 4 in the Crystal Structure of the Second Bromodomain of Human BRD2 in Complex with the Inhibitor Y13153
Mono view Stereo pair view
Fluorine binding site 2 out of 4 in 7wlnGo back to Fluorine Binding Sites List in 7wln
Fluorine binding site 2 out
of 4 in the Crystal Structure of the Second Bromodomain of Human BRD2 in Complex with the Inhibitor Y13153
Mono view Stereo pair view
Fluorine binding site 3 out of 4 in 7wlnGo back to Fluorine Binding Sites List in 7wln
Fluorine binding site 3 out
of 4 in the Crystal Structure of the Second Bromodomain of Human BRD2 in Complex with the Inhibitor Y13153
Mono view Stereo pair view
Fluorine binding site 4 out of 4 in 7wlnGo back to Fluorine Binding Sites List in 7wln
Fluorine binding site 4 out
of 4 in the Crystal Structure of the Second Bromodomain of Human BRD2 in Complex with the Inhibitor Y13153
Mono view Stereo pair view
Reference:
J.Li,
C.Zhang,
H.Xu,
C.Wang,
R.Dong,
H.Shen,
X.Zhuang,
X.Chen,
Q.Li,
J.Lu,
M.Zhang,
X.Wu,
K.M.Loomes,
Y.Zhou,
Y.Zhang,
J.Liu,
Y.Xu.
Structure-Based Discovery and Optimization of Furo[3,2- C ]Pyridin-4(5 H )-One Derivatives As Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (Bet) Inhibitors. J.Med.Chem. V. 65 5760 2022.
Page generated: Wed Apr 5 01:47:36 2023
ISSN: ISSN 0022-2623 PubMed: 35333526 DOI: 10.1021/ACS.JMEDCHEM.2C00100 |
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