Fluorine in PDB 7x2d: Cryo-Em Structure of the Tavapadon-Bound D1 Dopamine Receptor and Mini-Gs Complex

The binding sites of Fluorine atom in the Cryo-Em Structure of the Tavapadon-Bound D1 Dopamine Receptor and Mini-Gs Complex (pdb code 7x2d). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Cryo-Em Structure of the Tavapadon-Bound D1 Dopamine Receptor and Mini-Gs Complex, PDB code: 7x2d:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in the Cryo-Em Structure of the Tavapadon-Bound D1 Dopamine Receptor and Mini-Gs Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of the Tavapadon-Bound D1 Dopamine Receptor and Mini-Gs Complex within 5.0Å range: probe atom residue distance (Å) B Occ F:F502 b:66.5 occ:1.00 F16 F:86W502 0.0 66.5 1.0 C15 F:86W502 1.4 66.5 1.0 O08 F:86W502 1.9 66.5 1.0 F18 F:86W502 2.2 66.5 1.0 F17 F:86W502 2.3 66.5 1.0 C10 F:86W502 2.3 66.5 1.0 C09 F:86W502 2.5 66.5 1.0 C06 F:86W502 3.1 66.5 1.0 CD1 F:ILE104 3.5 56.1 1.0 ND2 F:ASN292 3.5 64.6 1.0 C11 F:86W502 3.6 66.5 1.0 OG F:SER198 3.7 58.0 1.0 N14 F:86W502 3.7 66.5 1.0 C07 F:86W502 3.8 66.5 1.0 CD2 F:LEU190 3.9 79.3 1.0 C05 F:86W502 4.1 66.5 1.0 CG F:ASN292 4.4 64.6 1.0 CB F:SER198 4.5 58.0 1.0 C12 F:86W502 4.5 66.5 1.0 C13 F:86W502 4.6 66.5 1.0 OD1 F:ASN292 4.6 64.6 1.0 CD1 F:LEU190 4.9 79.3 1.0 CZ F:PHE288 4.9 54.3 1.0 CG1 F:ILE104 4.9 56.1 1.0 CE2 F:PHE288 5.0 54.3 1.0 CE2 F:PHE289 5.0 55.2 1.0

Fluorine binding site 2 out of 3 in the Cryo-Em Structure of the Tavapadon-Bound D1 Dopamine Receptor and Mini-Gs Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Cryo-Em Structure of the Tavapadon-Bound D1 Dopamine Receptor and Mini-Gs Complex within 5.0Å range: probe atom residue distance (Å) B Occ F:F502 b:66.5 occ:1.00 F17 F:86W502 0.0 66.5 1.0 C15 F:86W502 1.4 66.5 1.0 F18 F:86W502 2.2 66.5 1.0 F16 F:86W502 2.3 66.5 1.0 C10 F:86W502 2.4 66.5 1.0 C11 F:86W502 2.9 66.5 1.0 OG F:SER198 3.4 58.0 1.0 C09 F:86W502 3.5 66.5 1.0 CB F:SER198 3.6 58.0 1.0 O08 F:86W502 3.7 66.5 1.0 O F:SER198 3.7 58.0 1.0 CE2 F:PHE289 3.8 55.2 1.0 C F:SER198 3.8 58.0 1.0 N F:SER199 4.1 55.3 1.0 CB F:SER202 4.1 48.4 1.0 C12 F:86W502 4.2 66.5 1.0 CZ F:PHE289 4.2 55.2 1.0 CA F:SER198 4.3 58.0 1.0 CA F:SER199 4.4 55.3 1.0 OG F:SER202 4.4 48.4 1.0 ND2 F:ASN292 4.4 64.6 1.0 CD1 F:ILE104 4.4 56.1 1.0 N14 F:86W502 4.6 66.5 1.0 OG F:SER199 4.7 55.3 1.0 OG1 F:THR108 4.7 44.0 1.0 CD2 F:PHE289 4.8 55.2 1.0 C13 F:86W502 4.9 66.5 1.0

Fluorine binding site 3 out of 3 in the Cryo-Em Structure of the Tavapadon-Bound D1 Dopamine Receptor and Mini-Gs Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Cryo-Em Structure of the Tavapadon-Bound D1 Dopamine Receptor and Mini-Gs Complex within 5.0Å range: probe atom residue distance (Å) B Occ F:F502 b:66.5 occ:1.00 F18 F:86W502 0.0 66.5 1.0 C15 F:86W502 1.4 66.5 1.0 F16 F:86W502 2.2 66.5 1.0 F17 F:86W502 2.2 66.5 1.0 CD1 F:ILE104 2.3 56.1 1.0 C10 F:86W502 2.3 66.5 1.0 C09 F:86W502 3.0 66.5 1.0 O08 F:86W502 3.1 66.5 1.0 C11 F:86W502 3.1 66.5 1.0 CG2 F:ILE104 3.4 56.1 1.0 CG1 F:ILE104 3.5 56.1 1.0 CB F:ILE104 3.9 56.1 1.0 OG F:SER198 4.0 58.0 1.0 CB F:SER198 4.1 58.0 1.0 C06 F:86W502 4.2 66.5 1.0 N14 F:86W502 4.2 66.5 1.0 CA F:ILE104 4.2 56.1 1.0 C12 F:86W502 4.3 66.5 1.0 C05 F:86W502 4.5 66.5 1.0 OH F:TYR194 4.6 69.9 1.0 OG1 F:THR108 4.6 44.0 1.0 C13 F:86W502 4.7 66.5 1.0 CD2 F:LEU190 4.8 79.3 1.0

X.Teng, S.Chen, Y.Nie, P.Xiao, X.Yu, Z.Shao, S.Zheng. Ligand Recognition and Biased Agonism of the D1 Dopamine Receptor. Nat Commun V. 13 3186 2022.
ISSN: ESSN 2041-1723
PubMed: 35676276
DOI: 10.1038/S41467-022-30929-W