Fluorine in PDB 7xr6: Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613

The structure of Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613 also contains other interesting chemical elements:

Bromine

(Br)

3 atoms

The binding sites of Fluorine atom in the Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613 (pdb code 7xr6). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613, PDB code: 7xr6:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613 within 5.0Å range: probe atom residue distance (Å) B Occ A:F601 b:60.5 occ:1.00 F1 A:GJ0601 0.0 60.5 1.0 C2 A:GJ0601 1.4 60.5 1.0 C3 A:GJ0601 2.4 60.5 1.0 C25 A:GJ0601 2.4 60.5 1.0 F4 A:GJ0601 2.7 60.5 1.0 CB A:LEU467 3.2 45.1 1.0 CG2 A:VAL468 3.4 48.0 1.0 N A:VAL468 3.6 48.0 1.0 C5 A:GJ0601 3.6 60.5 1.0 C23 A:GJ0601 3.6 60.5 1.0 C A:LEU467 3.8 45.1 1.0 OH A:TYR404 3.9 35.0 1.0 CG2 A:ILE464 4.0 42.9 1.0 CD2 A:LEU467 4.0 45.1 1.0 O A:ILE464 4.0 42.9 1.0 CA A:VAL468 4.0 48.0 1.0 C6 A:GJ0601 4.1 60.5 1.0 CA A:LEU467 4.1 45.1 1.0 OD2 A:ASP471 4.1 51.9 1.0 O A:LEU467 4.2 45.1 1.0 CG A:LEU467 4.2 45.1 1.0 CB A:VAL468 4.3 48.0 1.0 CB A:ASP471 4.4 51.9 1.0 CG A:ASP471 4.6 51.9 1.0 CD2 A:LEU447 4.9 35.4 1.0 C A:ILE464 5.0 42.9 1.0 CZ A:TYR404 5.0 35.0 1.0

Fluorine binding site 2 out of 6 in the Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613 within 5.0Å range: probe atom residue distance (Å) B Occ A:F601 b:60.5 occ:1.00 F4 A:GJ0601 0.0 60.5 1.0 C3 A:GJ0601 1.4 60.5 1.0 C2 A:GJ0601 2.4 60.5 1.0 C5 A:GJ0601 2.4 60.5 1.0 F1 A:GJ0601 2.7 60.5 1.0 SD A:MET450 3.0 32.4 1.0 CG A:MET450 3.4 32.4 1.0 CE1 A:TYR404 3.6 35.0 1.0 C25 A:GJ0601 3.6 60.5 1.0 C6 A:GJ0601 3.6 60.5 1.0 CB A:MET450 3.7 32.4 1.0 OH A:TYR404 3.8 35.0 1.0 CD2 A:LEU467 3.9 45.1 1.0 C23 A:GJ0601 4.1 60.5 1.0 CZ A:TYR404 4.2 35.0 1.0 CD1 A:TYR404 4.7 35.0 1.0 CE A:MET450 4.8 32.4 1.0 CB A:LEU467 4.8 45.1 1.0 O7 A:GJ0601 4.8 60.5 1.0 OD2 A:ASP471 4.9 51.9 1.0 O A:GLY446 4.9 41.4 1.0 CG A:LEU467 4.9 45.1 1.0 CA A:MET450 5.0 32.4 1.0

Fluorine binding site 3 out of 6 in the Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613 within 5.0Å range: probe atom residue distance (Å) B Occ B:F601 b:59.1 occ:1.00 F1 B:GJ0601 0.0 59.1 1.0 C2 B:GJ0601 1.4 59.1 1.0 C3 B:GJ0601 2.4 59.1 1.0 C25 B:GJ0601 2.4 59.1 1.0 F4 B:GJ0601 2.7 59.1 1.0 CB B:LEU467 3.2 42.8 1.0 OH B:TYR404 3.5 34.7 1.0 CG2 B:VAL468 3.5 45.4 1.0 C5 B:GJ0601 3.6 59.1 1.0 C23 B:GJ0601 3.6 59.1 1.0 N B:VAL468 3.7 45.4 1.0 CD2 B:LEU467 3.8 42.8 1.0 C B:LEU467 3.8 42.8 1.0 CG2 B:ILE464 3.9 40.3 1.0 CG B:LEU467 4.1 42.8 1.0 CA B:LEU467 4.1 42.8 1.0 CA B:VAL468 4.1 45.4 1.0 O B:ILE464 4.1 40.3 1.0 C6 B:GJ0601 4.1 59.1 1.0 O B:LEU467 4.3 42.8 1.0 OD2 B:ASP471 4.3 50.2 1.0 CB B:VAL468 4.4 45.4 1.0 CB B:ASP471 4.5 50.2 1.0 CZ B:TYR404 4.7 34.7 1.0 CG B:ASP471 4.7 50.2 1.0 CG B:MET450 4.9 31.6 1.0 CD2 B:LEU447 5.0 32.8 1.0 SD B:MET450 5.0 31.6 1.0

Fluorine binding site 4 out of 6 in the Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613 within 5.0Å range: probe atom residue distance (Å) B Occ B:F601 b:59.1 occ:1.00 F4 B:GJ0601 0.0 59.1 1.0 C3 B:GJ0601 1.4 59.1 1.0 C2 B:GJ0601 2.4 59.1 1.0 C5 B:GJ0601 2.4 59.1 1.0 F1 B:GJ0601 2.7 59.1 1.0 SD B:MET450 2.8 31.6 1.0 CG B:MET450 3.2 31.6 1.0 OH B:TYR404 3.4 34.7 1.0 CB B:MET450 3.4 31.6 1.0 CE1 B:TYR404 3.6 34.7 1.0 C25 B:GJ0601 3.6 59.1 1.0 C6 B:GJ0601 3.7 59.1 1.0 CD2 B:LEU467 4.0 42.8 1.0 CZ B:TYR404 4.0 34.7 1.0 C23 B:GJ0601 4.1 59.1 1.0 CE B:MET450 4.6 31.6 1.0 O B:GLY446 4.6 38.3 1.0 CD1 B:TYR404 4.7 34.7 1.0 CA B:MET450 4.7 31.6 1.0 O7 B:GJ0601 4.8 59.1 1.0 CB B:LEU467 4.9 42.8 1.0

Fluorine binding site 5 out of 6 in the Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613 within 5.0Å range: probe atom residue distance (Å) B Occ C:F602 b:59.0 occ:1.00 F1 C:GJ0602 0.0 59.0 1.0 C2 C:GJ0602 1.4 59.0 1.0 C3 C:GJ0602 2.4 59.0 1.0 C25 C:GJ0602 2.4 59.0 1.0 F4 C:GJ0602 2.7 59.0 1.0 CB C:LEU467 3.2 43.8 1.0 OH C:TYR404 3.4 33.6 1.0 CG2 C:VAL468 3.6 46.0 1.0 C5 C:GJ0602 3.6 59.0 1.0 C23 C:GJ0602 3.6 59.0 1.0 CD2 C:LEU467 3.8 43.8 1.0 N C:VAL468 3.8 46.0 1.0 C C:LEU467 3.9 43.8 1.0 CG2 C:ILE464 3.9 40.6 1.0 CG C:LEU467 4.1 43.8 1.0 O C:ILE464 4.1 40.6 1.0 C6 C:GJ0602 4.1 59.0 1.0 CA C:LEU467 4.2 43.8 1.0 CA C:VAL468 4.2 46.0 1.0 OD2 C:ASP471 4.3 51.8 1.0 O C:LEU467 4.4 43.8 1.0 CB C:VAL468 4.5 46.0 1.0 CB C:ASP471 4.5 51.8 1.0 CZ C:TYR404 4.6 33.6 1.0 CG C:ASP471 4.7 51.8 1.0 CG C:MET450 4.9 31.3 1.0 CD2 C:LEU447 5.0 33.2 1.0

Fluorine binding site 6 out of 6 in the Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Structure of Human Excitatory Amino Acid Transporter 2 (EAAT2) in Complex with Way-213613 within 5.0Å range: probe atom residue distance (Å) B Occ C:F602 b:59.0 occ:1.00 F4 C:GJ0602 0.0 59.0 1.0 C3 C:GJ0602 1.4 59.0 1.0 C2 C:GJ0602 2.4 59.0 1.0 C5 C:GJ0602 2.4 59.0 1.0 F1 C:GJ0602 2.7 59.0 1.0 SD C:MET450 2.9 31.3 1.0 CG C:MET450 3.2 31.3 1.0 OH C:TYR404 3.2 33.6 1.0 CB C:MET450 3.4 31.3 1.0 CE1 C:TYR404 3.5 33.6 1.0 C25 C:GJ0602 3.6 59.0 1.0 C6 C:GJ0602 3.7 59.0 1.0 CZ C:TYR404 3.8 33.6 1.0 CD2 C:LEU467 4.0 43.8 1.0 C23 C:GJ0602 4.1 59.0 1.0 CE C:MET450 4.6 31.3 1.0 CD1 C:TYR404 4.7 33.6 1.0 O C:GLY446 4.7 39.2 1.0 CA C:MET450 4.7 31.3 1.0 O7 C:GJ0602 4.8 59.0 1.0 CB C:LEU467 4.9 43.8 1.0

Z.Zhang, H.Chen, Z.Geng, Z.Yu, H.Li, Y.Dong, H.Zhang, Z.Huang, J.Jiang, Y.Zhao. Structural Basis of Ligand Binding Modes of Human EAAT2. Nat Commun V. 13 3329 2022.
ISSN: ESSN 2041-1723
PubMed: 35680945
DOI: 10.1038/S41467-022-31031-X