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Fluorine in PDB 7ymk: Estrogen Receptor Alpha Ligand Binding Domain C381S C417S Y537S Mutant in Complex with An Covalent Selective Estrogen Receptor Degrader 29C and Grip PeptideProtein crystallography data
The structure of Estrogen Receptor Alpha Ligand Binding Domain C381S C417S Y537S Mutant in Complex with An Covalent Selective Estrogen Receptor Degrader 29C and Grip Peptide, PDB code: 7ymk
was solved by
J.Min,
H.B.Hu,
Y.Yang,
C.E.Dong,
H.B.Zhou,
C.-C.Chen,
R.-T.Guo,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Estrogen Receptor Alpha Ligand Binding Domain C381S C417S Y537S Mutant in Complex with An Covalent Selective Estrogen Receptor Degrader 29C and Grip Peptide
(pdb code 7ymk). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Estrogen Receptor Alpha Ligand Binding Domain C381S C417S Y537S Mutant in Complex with An Covalent Selective Estrogen Receptor Degrader 29C and Grip Peptide, PDB code: 7ymk: Jump to Fluorine binding site number: 1; 2; 3; Fluorine binding site 1 out of 3 in 7ymkGo back to Fluorine Binding Sites List in 7ymk
Fluorine binding site 1 out
of 3 in the Estrogen Receptor Alpha Ligand Binding Domain C381S C417S Y537S Mutant in Complex with An Covalent Selective Estrogen Receptor Degrader 29C and Grip Peptide
Mono view Stereo pair view
Fluorine binding site 2 out of 3 in 7ymkGo back to Fluorine Binding Sites List in 7ymk
Fluorine binding site 2 out
of 3 in the Estrogen Receptor Alpha Ligand Binding Domain C381S C417S Y537S Mutant in Complex with An Covalent Selective Estrogen Receptor Degrader 29C and Grip Peptide
Mono view Stereo pair view
Fluorine binding site 3 out of 3 in 7ymkGo back to Fluorine Binding Sites List in 7ymk
Fluorine binding site 3 out
of 3 in the Estrogen Receptor Alpha Ligand Binding Domain C381S C417S Y537S Mutant in Complex with An Covalent Selective Estrogen Receptor Degrader 29C and Grip Peptide
Mono view Stereo pair view
Reference:
Y.Wang,
J.Min,
X.Deng,
T.Feng,
H.Hu,
X.Guo,
Y.Cheng,
B.Xie,
Y.Yang,
C.C.Chen,
R.T.Guo,
C.Dong,
H.B.Zhou.
Discovery of Novel Covalent Selective Estrogen Receptor Degraders Against Endocrine-Resistant Breast Cancer Acta Pharm Sin B 2023.
Page generated: Thu Jul 27 13:40:29 2023
ISSN: ESSN 2211-3843 DOI: 10.1016/J.APSB.2023.05.005 |
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