Fluorine in PDB 7yq4: Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined

Fluorine Binding Sites:

The binding sites of Fluorine atom in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined (pdb code 7yq4). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined, PDB code: 7yq4:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in 7yq4

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Fluorine binding site 1 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined within 5.0Å range:
probe atom residue distance (Å) B Occ
G:F2

b:58.0
occ:1.00
F G:AF22 0.0 58.0 1.0
C2' G:AF22 1.4 58.0 1.0
C3' G:AF22 2.2 58.0 1.0
C1' G:AF22 2.5 58.0 1.0
O3' G:AF22 2.6 58.0 1.0
C4' G:AF22 2.7 58.0 1.0
C33 G:85Y20 3.1 35.0 1.0
O4' G:AF22 3.1 58.0 1.0
C4' G:DUZ3 3.3 50.0 1.0
C32 G:85Y20 3.3 35.0 1.0
C27 G:85Y20 3.4 35.0 1.0
C5' G:DUZ3 3.5 50.0 1.0
O4' G:DUZ3 3.5 50.0 1.0
O5' G:DUZ3 3.6 50.0 1.0
N9 G:AF22 3.6 58.0 1.0
P G:DUZ3 3.7 50.0 1.0
C31 G:85Y20 3.8 35.0 1.0
C26 G:85Y20 3.9 35.0 1.0
C28 G:85Y20 4.0 35.0 1.0
C5' G:AF22 4.1 58.0 1.0
C30 G:85Y20 4.1 35.0 1.0
C8 G:AF22 4.4 58.0 1.0
C3' G:DUZ3 4.6 50.0 1.0
C4 G:AF22 4.6 58.0 1.0
C1' G:DUZ3 4.6 50.0 1.0
O5' G:AF22 4.7 58.0 1.0
OP2 G:DUZ3 4.7 50.0 1.0
OP1 G:DUZ3 4.7 50.0 1.0
C25 G:85Y20 4.8 35.0 1.0
C29 G:85Y20 4.9 35.0 1.0
N3 G:AF22 4.9 58.0 1.0
O3' G:DUZ3 5.0 50.0 1.0

Fluorine binding site 2 out of 6 in 7yq4

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Fluorine binding site 2 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined within 5.0Å range:
probe atom residue distance (Å) B Occ
G:F6

b:40.4
occ:1.00
F2' G:CFZ6 0.0 40.4 1.0
C2' G:CFZ6 1.4 40.4 1.0
C1' G:CFZ6 2.2 40.4 1.0
C3' G:CFZ6 2.5 40.4 1.0
N7 G:DG7 2.8 36.8 1.0
O3' G:CFZ6 2.9 40.4 1.0
N1 G:CFZ6 2.9 40.4 1.0
C8 G:DG7 3.1 36.8 1.0
C6 G:CFZ6 3.2 40.4 1.0
OP2 G:DG7 3.2 36.8 1.0
O4' G:CFZ6 3.5 40.4 1.0
C4' G:CFZ6 3.5 40.4 1.0
P G:DG7 3.6 36.8 1.0
C5 G:DG7 3.7 36.8 1.0
O5' G:DG7 4.0 36.8 1.0
N9 G:DG7 4.1 36.8 1.0
O5' G:CFZ6 4.1 40.4 1.0
C2 G:CFZ6 4.1 40.4 1.0
C5' G:CFZ6 4.4 40.4 1.0
C4 G:DG7 4.4 36.8 1.0
C6 G:DG7 4.5 36.8 1.0
C5 G:CFZ6 4.5 40.4 1.0
O2 G:CFZ6 4.6 40.4 1.0
O6 G:DG7 4.7 36.8 1.0
O4' G:DG7 4.9 36.8 1.0
OP1 G:DG7 5.0 36.8 1.0

Fluorine binding site 3 out of 6 in 7yq4

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Fluorine binding site 3 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined within 5.0Å range:
probe atom residue distance (Å) B Occ
G:F8

b:29.5
occ:1.00
F2' G:CFZ8 0.0 29.5 1.0
C2' G:CFZ8 1.4 29.5 1.0
C1' G:CFZ8 2.2 29.5 1.0
C3' G:CFZ8 2.5 29.5 1.0
O3' G:CFZ8 2.6 29.5 1.0
O2 G:CFZ8 3.1 29.5 1.0
O5' G:DA9 3.2 38.8 1.0
CD2 F:PHE39 3.2 29.5 1.0
N1 G:CFZ8 3.2 29.5 1.0
C4' G:CFZ8 3.2 29.5 1.0
O4' G:CFZ8 3.3 29.5 1.0
CE2 F:TYR67 3.5 29.5 1.0
P G:DA9 3.5 38.8 1.0
C2 G:CFZ8 3.5 29.5 1.0
CE2 F:PHE39 3.6 29.5 1.0
OP2 G:DA9 4.0 38.8 1.0
CD2 F:TYR67 4.1 29.5 1.0
C32 G:85Y10 4.3 33.2 1.0
C5' G:DA9 4.3 38.8 1.0
CG F:PHE39 4.4 29.5 1.0
CZ F:TYR67 4.5 29.5 1.0
C6 G:CFZ8 4.5 29.5 1.0
OH F:TYR67 4.6 29.5 1.0
C5' G:CFZ8 4.7 29.5 1.0
C31 G:85Y10 4.7 33.2 1.0
OP1 G:DA9 4.7 38.8 1.0
CB F:PHE39 4.8 29.5 1.0
CZ F:PHE39 5.0 29.5 1.0
N3 G:CFZ8 5.0 29.5 1.0

Fluorine binding site 4 out of 6 in 7yq4

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Fluorine binding site 4 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined within 5.0Å range:
probe atom residue distance (Å) B Occ
G:F12

b:48.0
occ:1.00
F G:AF212 0.0 48.0 1.0
C2' G:AF212 1.4 48.0 1.0
C3' G:AF212 2.3 48.0 1.0
C1' G:AF212 2.5 48.0 1.0
O3' G:AF212 2.6 48.0 1.0
OP2 G:OMG13 2.7 49.8 1.0
P G:OMG13 3.1 49.8 1.0
O4' G:AF212 3.3 48.0 1.0
C4' G:AF212 3.4 48.0 1.0
N9 G:AF212 3.5 48.0 1.0
N3 G:AF212 3.7 48.0 1.0
C4 G:AF212 3.9 48.0 1.0
OP1 G:OMG13 4.0 49.8 1.0
O5' G:OMG13 4.5 49.8 1.0
C5' G:AF212 4.6 48.0 1.0
O5' G:AF212 4.6 48.0 1.0
C8 G:AF212 4.7 48.0 1.0
C2 G:AF212 4.8 48.0 1.0

Fluorine binding site 5 out of 6 in 7yq4

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Fluorine binding site 5 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined within 5.0Å range:
probe atom residue distance (Å) B Occ
G:F19

b:29.5
occ:1.00
F G:AF219 0.0 29.5 1.0
C2' G:AF219 1.4 29.5 1.0
C3' G:AF219 2.2 29.5 1.0
O3' G:AF219 2.4 29.5 1.0
C1' G:AF219 2.5 29.5 1.0
N3 G:AF219 3.1 29.5 1.0
P G:85Y20 3.2 35.0 1.0
N9 G:AF219 3.3 29.5 1.0
C4 G:AF219 3.4 29.5 1.0
C4' G:AF219 3.5 29.5 1.0
O4' G:AF219 3.5 29.5 1.0
OP2 G:85Y20 3.5 35.0 1.0
OP1 G:85Y20 3.7 35.0 1.0
C2 G:AF219 4.1 29.5 1.0
NH2 E:ARG479 4.2 29.5 1.0
NH1 E:ARG479 4.3 29.5 1.0
C5' G:AF219 4.4 29.5 1.0
C8 G:AF219 4.5 29.5 1.0
CD2 E:LEU486 4.5 24.6 1.0
CZ E:ARG479 4.6 29.5 1.0
C5 G:AF219 4.6 29.5 1.0
N4 G:OMC21 4.7 27.5 1.0
O5' G:AF219 4.7 29.5 1.0
O5' G:85Y20 4.9 35.0 1.0

Fluorine binding site 6 out of 6 in 7yq4

Go back to Fluorine Binding Sites List in 7yq4
Fluorine binding site 6 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined within 5.0Å range:
probe atom residue distance (Å) B Occ
G:F22

b:34.9
occ:1.00
F2' G:CFZ22 0.0 34.9 1.0
C2' G:CFZ22 1.4 34.9 1.0
C1' G:CFZ22 2.2 34.9 1.0
C3' G:CFZ22 2.5 34.9 1.0
O3' G:CFZ22 2.7 34.9 1.0
C4' G:CFZ22 3.0 34.9 1.0
O4' G:CFZ22 3.2 34.9 1.0
O2 G:CFZ22 3.2 34.9 1.0
N1 G:CFZ22 3.3 34.9 1.0
C2 G:CFZ22 3.7 34.9 1.0
O5' G:DG23 3.8 42.9 1.0
P G:DG23 4.0 42.9 1.0
O4' G:DG23 4.1 42.9 1.0
C5' G:CFZ22 4.5 34.9 1.0
C6 G:CFZ22 4.5 34.9 1.0
OP1 G:DG23 4.6 42.9 1.0
C8 G:DG23 4.6 42.9 1.0
N9 G:DG23 4.9 42.9 1.0
C1' G:DG23 4.9 42.9 1.0

Reference:

J.Kim, N.O.Yunn, M.Park, J.Kim, S.Park, Y.Kim, J.Noh, S.H.Ryu, Y.Cho. Functional Selectivity of Insulin Receptor Revealed By Aptamer-Trapped Receptor Structures Nat Commun V. 13 6500 2022.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-022-34292-8
Page generated: Fri Aug 2 15:47:58 2024

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