Fluorine in PDB 7yq4: Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined

The binding sites of Fluorine atom in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined (pdb code 7yq4). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined, PDB code: 7yq4:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined within 5.0Å range: probe atom residue distance (Å) B Occ G:F2 b:58.0 occ:1.00 F G:AF22 0.0 58.0 1.0 C2' G:AF22 1.4 58.0 1.0 C3' G:AF22 2.2 58.0 1.0 C1' G:AF22 2.5 58.0 1.0 O3' G:AF22 2.6 58.0 1.0 C4' G:AF22 2.7 58.0 1.0 C33 G:85Y20 3.1 35.0 1.0 O4' G:AF22 3.1 58.0 1.0 C4' G:DUZ3 3.3 50.0 1.0 C32 G:85Y20 3.3 35.0 1.0 C27 G:85Y20 3.4 35.0 1.0 C5' G:DUZ3 3.5 50.0 1.0 O4' G:DUZ3 3.5 50.0 1.0 O5' G:DUZ3 3.6 50.0 1.0 N9 G:AF22 3.6 58.0 1.0 P G:DUZ3 3.7 50.0 1.0 C31 G:85Y20 3.8 35.0 1.0 C26 G:85Y20 3.9 35.0 1.0 C28 G:85Y20 4.0 35.0 1.0 C5' G:AF22 4.1 58.0 1.0 C30 G:85Y20 4.1 35.0 1.0 C8 G:AF22 4.4 58.0 1.0 C3' G:DUZ3 4.6 50.0 1.0 C4 G:AF22 4.6 58.0 1.0 C1' G:DUZ3 4.6 50.0 1.0 O5' G:AF22 4.7 58.0 1.0 OP2 G:DUZ3 4.7 50.0 1.0 OP1 G:DUZ3 4.7 50.0 1.0 C25 G:85Y20 4.8 35.0 1.0 C29 G:85Y20 4.9 35.0 1.0 N3 G:AF22 4.9 58.0 1.0 O3' G:DUZ3 5.0 50.0 1.0

Fluorine binding site 2 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined within 5.0Å range: probe atom residue distance (Å) B Occ G:F6 b:40.4 occ:1.00 F2' G:CFZ6 0.0 40.4 1.0 C2' G:CFZ6 1.4 40.4 1.0 C1' G:CFZ6 2.2 40.4 1.0 C3' G:CFZ6 2.5 40.4 1.0 N7 G:DG7 2.8 36.8 1.0 O3' G:CFZ6 2.9 40.4 1.0 N1 G:CFZ6 2.9 40.4 1.0 C8 G:DG7 3.1 36.8 1.0 C6 G:CFZ6 3.2 40.4 1.0 OP2 G:DG7 3.2 36.8 1.0 O4' G:CFZ6 3.5 40.4 1.0 C4' G:CFZ6 3.5 40.4 1.0 P G:DG7 3.6 36.8 1.0 C5 G:DG7 3.7 36.8 1.0 O5' G:DG7 4.0 36.8 1.0 N9 G:DG7 4.1 36.8 1.0 O5' G:CFZ6 4.1 40.4 1.0 C2 G:CFZ6 4.1 40.4 1.0 C5' G:CFZ6 4.4 40.4 1.0 C4 G:DG7 4.4 36.8 1.0 C6 G:DG7 4.5 36.8 1.0 C5 G:CFZ6 4.5 40.4 1.0 O2 G:CFZ6 4.6 40.4 1.0 O6 G:DG7 4.7 36.8 1.0 O4' G:DG7 4.9 36.8 1.0 OP1 G:DG7 5.0 36.8 1.0

Fluorine binding site 3 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined within 5.0Å range: probe atom residue distance (Å) B Occ G:F8 b:29.5 occ:1.00 F2' G:CFZ8 0.0 29.5 1.0 C2' G:CFZ8 1.4 29.5 1.0 C1' G:CFZ8 2.2 29.5 1.0 C3' G:CFZ8 2.5 29.5 1.0 O3' G:CFZ8 2.6 29.5 1.0 O2 G:CFZ8 3.1 29.5 1.0 O5' G:DA9 3.2 38.8 1.0 CD2 F:PHE39 3.2 29.5 1.0 N1 G:CFZ8 3.2 29.5 1.0 C4' G:CFZ8 3.2 29.5 1.0 O4' G:CFZ8 3.3 29.5 1.0 CE2 F:TYR67 3.5 29.5 1.0 P G:DA9 3.5 38.8 1.0 C2 G:CFZ8 3.5 29.5 1.0 CE2 F:PHE39 3.6 29.5 1.0 OP2 G:DA9 4.0 38.8 1.0 CD2 F:TYR67 4.1 29.5 1.0 C32 G:85Y10 4.3 33.2 1.0 C5' G:DA9 4.3 38.8 1.0 CG F:PHE39 4.4 29.5 1.0 CZ F:TYR67 4.5 29.5 1.0 C6 G:CFZ8 4.5 29.5 1.0 OH F:TYR67 4.6 29.5 1.0 C5' G:CFZ8 4.7 29.5 1.0 C31 G:85Y10 4.7 33.2 1.0 OP1 G:DA9 4.7 38.8 1.0 CB F:PHE39 4.8 29.5 1.0 CZ F:PHE39 5.0 29.5 1.0 N3 G:CFZ8 5.0 29.5 1.0

Fluorine binding site 4 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined within 5.0Å range: probe atom residue distance (Å) B Occ G:F12 b:48.0 occ:1.00 F G:AF212 0.0 48.0 1.0 C2' G:AF212 1.4 48.0 1.0 C3' G:AF212 2.3 48.0 1.0 C1' G:AF212 2.5 48.0 1.0 O3' G:AF212 2.6 48.0 1.0 OP2 G:OMG13 2.7 49.8 1.0 P G:OMG13 3.1 49.8 1.0 O4' G:AF212 3.3 48.0 1.0 C4' G:AF212 3.4 48.0 1.0 N9 G:AF212 3.5 48.0 1.0 N3 G:AF212 3.7 48.0 1.0 C4 G:AF212 3.9 48.0 1.0 OP1 G:OMG13 4.0 49.8 1.0 O5' G:OMG13 4.5 49.8 1.0 C5' G:AF212 4.6 48.0 1.0 O5' G:AF212 4.6 48.0 1.0 C8 G:AF212 4.7 48.0 1.0 C2 G:AF212 4.8 48.0 1.0

Fluorine binding site 5 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined within 5.0Å range: probe atom residue distance (Å) B Occ G:F19 b:29.5 occ:1.00 F G:AF219 0.0 29.5 1.0 C2' G:AF219 1.4 29.5 1.0 C3' G:AF219 2.2 29.5 1.0 O3' G:AF219 2.4 29.5 1.0 C1' G:AF219 2.5 29.5 1.0 N3 G:AF219 3.1 29.5 1.0 P G:85Y20 3.2 35.0 1.0 N9 G:AF219 3.3 29.5 1.0 C4 G:AF219 3.4 29.5 1.0 C4' G:AF219 3.5 29.5 1.0 O4' G:AF219 3.5 29.5 1.0 OP2 G:85Y20 3.5 35.0 1.0 OP1 G:85Y20 3.7 35.0 1.0 C2 G:AF219 4.1 29.5 1.0 NH2 E:ARG479 4.2 29.5 1.0 NH1 E:ARG479 4.3 29.5 1.0 C5' G:AF219 4.4 29.5 1.0 C8 G:AF219 4.5 29.5 1.0 CD2 E:LEU486 4.5 24.6 1.0 CZ E:ARG479 4.6 29.5 1.0 C5 G:AF219 4.6 29.5 1.0 N4 G:OMC21 4.7 27.5 1.0 O5' G:AF219 4.7 29.5 1.0 O5' G:85Y20 4.9 35.0 1.0

Fluorine binding site 6 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin - Locally Refined within 5.0Å range: probe atom residue distance (Å) B Occ G:F22 b:34.9 occ:1.00 F2' G:CFZ22 0.0 34.9 1.0 C2' G:CFZ22 1.4 34.9 1.0 C1' G:CFZ22 2.2 34.9 1.0 C3' G:CFZ22 2.5 34.9 1.0 O3' G:CFZ22 2.7 34.9 1.0 C4' G:CFZ22 3.0 34.9 1.0 O4' G:CFZ22 3.2 34.9 1.0 O2 G:CFZ22 3.2 34.9 1.0 N1 G:CFZ22 3.3 34.9 1.0 C2 G:CFZ22 3.7 34.9 1.0 O5' G:DG23 3.8 42.9 1.0 P G:DG23 4.0 42.9 1.0 O4' G:DG23 4.1 42.9 1.0 C5' G:CFZ22 4.5 34.9 1.0 C6 G:CFZ22 4.5 34.9 1.0 OP1 G:DG23 4.6 42.9 1.0 C8 G:DG23 4.6 42.9 1.0 N9 G:DG23 4.9 42.9 1.0 C1' G:DG23 4.9 42.9 1.0

J.Kim, N.O.Yunn, M.Park, J.Kim, S.Park, Y.Kim, J.Noh, S.H.Ryu, Y.Cho. Functional Selectivity of Insulin Receptor Revealed By Aptamer-Trapped Receptor Structures Nat Commun V. 13 6500 2022.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-022-34292-8