Fluorine in PDB 7yq5: Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin

All present enzymatic activity of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin:
2.7.10.1;

The binding sites of Fluorine atom in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin (pdb code 7yq5). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin, PDB code: 7yq5:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6;

Fluorine binding site 1 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin within 5.0Å range: probe atom residue distance (Å) B Occ G:F2 b:58.0 occ:1.00 F G:AF22 0.0 58.0 1.0 C2' G:AF22 1.4 58.0 1.0 C3' G:AF22 2.2 58.0 1.0 C1' G:AF22 2.5 58.0 1.0 O3' G:AF22 2.6 58.0 1.0 C4' G:AF22 2.7 58.0 1.0 C33 G:85Y20 3.1 35.0 1.0 O4' G:AF22 3.1 58.0 1.0 C4' G:DUZ3 3.3 50.0 1.0 C32 G:85Y20 3.3 35.0 1.0 C27 G:85Y20 3.4 35.0 1.0 C5' G:DUZ3 3.5 50.0 1.0 O4' G:DUZ3 3.5 50.0 1.0 O5' G:DUZ3 3.6 50.0 1.0 N9 G:AF22 3.6 58.0 1.0 P G:DUZ3 3.7 50.0 1.0 C31 G:85Y20 3.8 35.0 1.0 C26 G:85Y20 3.9 35.0 1.0 C28 G:85Y20 4.0 35.0 1.0 C5' G:AF22 4.1 58.0 1.0 C30 G:85Y20 4.1 35.0 1.0 C8 G:AF22 4.4 58.0 1.0 C3' G:DUZ3 4.6 50.0 1.0 C4 G:AF22 4.6 58.0 1.0 C1' G:DUZ3 4.6 50.0 1.0 O5' G:AF22 4.7 58.0 1.0 OP2 G:DUZ3 4.7 50.0 1.0 OP1 G:DUZ3 4.7 50.0 1.0 C25 G:85Y20 4.8 35.0 1.0 C29 G:85Y20 4.9 35.0 1.0 N3 G:AF22 4.9 58.0 1.0 O3' G:DUZ3 5.0 50.0 1.0

Fluorine binding site 2 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin within 5.0Å range: probe atom residue distance (Å) B Occ G:F6 b:40.4 occ:1.00 F2' G:CFZ6 0.0 40.4 1.0 C2' G:CFZ6 1.4 40.4 1.0 C1' G:CFZ6 2.2 40.4 1.0 C3' G:CFZ6 2.5 40.4 1.0 N7 G:DG7 2.8 36.8 1.0 O3' G:CFZ6 2.9 40.4 1.0 N1 G:CFZ6 2.9 40.4 1.0 C8 G:DG7 3.1 36.8 1.0 C6 G:CFZ6 3.2 40.4 1.0 OP2 G:DG7 3.2 36.8 1.0 O4' G:CFZ6 3.5 40.4 1.0 C4' G:CFZ6 3.5 40.4 1.0 P G:DG7 3.6 36.8 1.0 C5 G:DG7 3.7 36.8 1.0 O5' G:DG7 4.0 36.8 1.0 N9 G:DG7 4.1 36.8 1.0 O5' G:CFZ6 4.1 40.4 1.0 C2 G:CFZ6 4.1 40.4 1.0 C5' G:CFZ6 4.4 40.4 1.0 C4 G:DG7 4.4 36.8 1.0 C6 G:DG7 4.5 36.8 1.0 C5 G:CFZ6 4.5 40.4 1.0 O2 G:CFZ6 4.6 40.4 1.0 O6 G:DG7 4.7 36.8 1.0 O4' G:DG7 4.9 36.8 1.0 OP1 G:DG7 5.0 36.8 1.0

Fluorine binding site 3 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin within 5.0Å range: probe atom residue distance (Å) B Occ G:F8 b:29.5 occ:1.00 F2' G:CFZ8 0.0 29.5 1.0 C2' G:CFZ8 1.4 29.5 1.0 C1' G:CFZ8 2.2 29.5 1.0 C3' G:CFZ8 2.5 29.5 1.0 O3' G:CFZ8 2.6 29.5 1.0 O2 G:CFZ8 3.1 29.5 1.0 O5' G:DA9 3.2 38.8 1.0 CD2 F:PHE39 3.2 29.5 1.0 N1 G:CFZ8 3.2 29.5 1.0 C4' G:CFZ8 3.2 29.5 1.0 O4' G:CFZ8 3.3 29.5 1.0 CE2 F:TYR67 3.5 29.5 1.0 P G:DA9 3.5 38.8 1.0 C2 G:CFZ8 3.5 29.5 1.0 CE2 F:PHE39 3.6 29.5 1.0 OP2 G:DA9 4.0 38.8 1.0 CD2 F:TYR67 4.1 29.5 1.0 C32 G:85Y10 4.3 33.2 1.0 C5' G:DA9 4.3 38.8 1.0 CG F:PHE39 4.4 29.5 1.0 CZ F:TYR67 4.5 29.5 1.0 C6 G:CFZ8 4.5 29.5 1.0 OH F:TYR67 4.6 29.5 1.0 C5' G:CFZ8 4.7 29.5 1.0 C31 G:85Y10 4.7 33.2 1.0 OP1 G:DA9 4.7 38.8 1.0 CB F:PHE39 4.8 29.5 1.0 CZ F:PHE39 5.0 29.5 1.0 N3 G:CFZ8 5.0 29.5 1.0

Fluorine binding site 4 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin within 5.0Å range: probe atom residue distance (Å) B Occ G:F12 b:48.0 occ:1.00 F G:AF212 0.0 48.0 1.0 C2' G:AF212 1.4 48.0 1.0 C3' G:AF212 2.3 48.0 1.0 C1' G:AF212 2.5 48.0 1.0 O3' G:AF212 2.6 48.0 1.0 OP2 G:OMG13 2.7 49.8 1.0 P G:OMG13 3.1 49.8 1.0 O4' G:AF212 3.3 48.0 1.0 C4' G:AF212 3.4 48.0 1.0 N9 G:AF212 3.5 48.0 1.0 N3 G:AF212 3.7 48.0 1.0 C4 G:AF212 3.9 48.0 1.0 OP1 G:OMG13 4.0 49.8 1.0 O5' G:OMG13 4.5 49.8 1.0 C5' G:AF212 4.6 48.0 1.0 O5' G:AF212 4.6 48.0 1.0 C8 G:AF212 4.7 48.0 1.0 C2 G:AF212 4.8 48.0 1.0

Fluorine binding site 5 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin within 5.0Å range: probe atom residue distance (Å) B Occ G:F19 b:29.5 occ:1.00 F G:AF219 0.0 29.5 1.0 C2' G:AF219 1.4 29.5 1.0 C3' G:AF219 2.2 29.5 1.0 O3' G:AF219 2.4 29.5 1.0 C1' G:AF219 2.5 29.5 1.0 N3 G:AF219 3.1 29.5 1.0 P G:85Y20 3.2 35.0 1.0 N9 G:AF219 3.3 29.5 1.0 C4 G:AF219 3.4 29.5 1.0 C4' G:AF219 3.5 29.5 1.0 O4' G:AF219 3.5 29.5 1.0 OP2 G:85Y20 3.5 35.0 1.0 OP1 G:85Y20 3.7 35.0 1.0 C2 G:AF219 4.1 29.5 1.0 NH2 E:ARG479 4.2 29.5 1.0 NH1 E:ARG479 4.3 29.5 1.0 C5' G:AF219 4.4 29.5 1.0 C8 G:AF219 4.5 29.5 1.0 CD2 E:LEU486 4.5 24.6 1.0 CZ E:ARG479 4.6 29.5 1.0 C5 G:AF219 4.6 29.5 1.0 N4 G:OMC21 4.7 27.5 1.0 O5' G:AF219 4.7 29.5 1.0 O5' G:85Y20 4.9 35.0 1.0

Fluorine binding site 6 out of 6 in the Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Human Insulin Receptor Bound with A62 Dna Aptamer and Insulin within 5.0Å range: probe atom residue distance (Å) B Occ G:F22 b:34.9 occ:1.00 F2' G:CFZ22 0.0 34.9 1.0 C2' G:CFZ22 1.4 34.9 1.0 C1' G:CFZ22 2.2 34.9 1.0 C3' G:CFZ22 2.5 34.9 1.0 O3' G:CFZ22 2.7 34.9 1.0 C4' G:CFZ22 3.0 34.9 1.0 O4' G:CFZ22 3.2 34.9 1.0 O2 G:CFZ22 3.2 34.9 1.0 N1 G:CFZ22 3.3 34.9 1.0 C2 G:CFZ22 3.7 34.9 1.0 O5' G:DG23 3.8 42.9 1.0 P G:DG23 4.0 42.9 1.0 O4' G:DG23 4.1 42.9 1.0 C5' G:CFZ22 4.5 34.9 1.0 C6 G:CFZ22 4.5 34.9 1.0 OP1 G:DG23 4.6 42.9 1.0 C8 G:DG23 4.6 42.9 1.0 N9 G:DG23 4.9 42.9 1.0 C1' G:DG23 4.9 42.9 1.0

J.Kim, N.O.Yunn, M.Park, J.Kim, S.Park, Y.Kim, J.Noh, S.H.Ryu, Y.Cho. Functional Selectivity of Insulin Receptor Revealed By Aptamer-Trapped Receptor Structures Nat Commun V. 13 6500 2022.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-022-34292-8