Fluorine in PDB 7yq6: Human Insulin Receptor Bound with A62 Dna Aptamer

All present enzymatic activity of Human Insulin Receptor Bound with A62 Dna Aptamer:
2.7.10.1;

Pages:

>>> Page 1 <<< Page 2, Binding sites: 11 - 12;

Binding sites:

The binding sites of Fluorine atom in the Human Insulin Receptor Bound with A62 Dna Aptamer (pdb code 7yq6). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 12 binding sites of Fluorine where determined in the Human Insulin Receptor Bound with A62 Dna Aptamer, PDB code: 7yq6:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 12 in the Human Insulin Receptor Bound with A62 Dna Aptamer


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Human Insulin Receptor Bound with A62 Dna Aptamer within 5.0Å range: probe atom residue distance (Å) B Occ G:F2 b:135.3 occ:1.00 F G:AF22 0.0 135.3 1.0 C2' G:AF22 1.4 135.3 1.0 C3' G:AF22 2.2 135.3 1.0 O3' G:AF22 2.3 135.3 1.0 C1' G:AF22 2.5 135.3 1.0 C4' G:AF22 3.2 135.3 1.0 O4' G:DUZ3 3.2 97.0 1.0 C30 G:85Y20 3.3 64.9 1.0 C26 G:85Y20 3.3 64.9 1.0 O4' G:AF22 3.3 135.3 1.0 N9 G:AF22 3.5 135.3 1.0 C31 G:85Y20 3.6 64.9 1.0 C27 G:85Y20 3.6 64.9 1.0 P G:DUZ3 3.7 97.0 1.0 C5' G:DUZ3 3.8 97.0 1.0 C25 G:85Y20 3.8 64.9 1.0 C32 G:85Y20 3.8 64.9 1.0 C33 G:85Y20 3.9 64.9 1.0 C4' G:DUZ3 4.0 97.0 1.0 N3 G:AF22 4.0 135.3 1.0 C4 G:AF22 4.0 135.3 1.0 C6 G:DUZ3 4.1 97.0 1.0 OP2 G:DUZ3 4.1 97.0 1.0 O5' G:DUZ3 4.3 97.0 1.0 C28 G:85Y20 4.4 64.9 1.0 C1' G:DUZ3 4.4 97.0 1.0 C5' G:AF22 4.5 135.3 1.0 C24 G:85Y20 4.5 64.9 1.0 C8 G:AF22 4.6 135.3 1.0 C29 G:85Y20 4.8 64.9 1.0 OP1 G:DUZ3 4.8 97.0 1.0 N1 G:DUZ3 4.8 97.0 1.0 O5' G:AF22 4.8 135.3 1.0 O22 G:DUZ3 4.8 97.0 1.0

Fluorine binding site 2 out of 12 in the Human Insulin Receptor Bound with A62 Dna Aptamer


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Human Insulin Receptor Bound with A62 Dna Aptamer within 5.0Å range: probe atom residue distance (Å) B Occ G:F6 b:97.0 occ:1.00 F2' G:CFZ6 0.0 97.0 1.0 C2' G:CFZ6 1.4 97.0 1.0 C1' G:CFZ6 2.2 97.0 1.0 C3' G:CFZ6 2.5 97.0 1.0 OP2 G:DG7 2.6 84.1 1.0 O3' G:CFZ6 2.9 97.0 1.0 N1 G:CFZ6 3.0 97.0 1.0 C8 G:DG7 3.0 84.1 1.0 C6 G:CFZ6 3.2 97.0 1.0 P G:DG7 3.3 84.1 1.0 N7 G:DG7 3.4 84.1 1.0 O4' G:CFZ6 3.5 97.0 1.0 C4' G:CFZ6 3.5 97.0 1.0 N9 G:DG7 4.0 84.1 1.0 O5' G:CFZ6 4.1 97.0 1.0 C5' G:CFZ6 4.2 97.0 1.0 O2P G:CFZ6 4.2 97.0 1.0 C2' G:DG7 4.3 84.1 1.0 C2 G:CFZ6 4.4 97.0 1.0 OP1 G:DG7 4.4 84.1 1.0 O5' G:DG7 4.4 84.1 1.0 C5 G:DG7 4.5 84.1 1.0 C5 G:CFZ6 4.6 97.0 1.0 C1' G:DG7 4.6 84.1 1.0 O4' G:DG7 4.7 84.1 1.0 C5' G:DG7 4.8 84.1 1.0 C4 G:DG7 4.8 84.1 1.0 O2 G:CFZ6 4.8 97.0 1.0 P G:CFZ6 4.8 97.0 1.0

Fluorine binding site 3 out of 12 in the Human Insulin Receptor Bound with A62 Dna Aptamer


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Human Insulin Receptor Bound with A62 Dna Aptamer within 5.0Å range: probe atom residue distance (Å) B Occ G:F8 b:97.0 occ:1.00 F2' G:CFZ8 0.0 97.0 1.0 C2' G:CFZ8 1.4 97.0 1.0 C1' G:CFZ8 2.2 97.0 1.0 C3' G:CFZ8 2.5 97.0 1.0 O3' G:CFZ8 2.6 97.0 1.0 O5' G:DA9 2.9 78.4 1.0 N1 G:CFZ8 3.1 97.0 1.0 C6 G:CFZ8 3.3 97.0 1.0 C4' G:CFZ8 3.3 97.0 1.0 O4' G:CFZ8 3.4 97.0 1.0 P G:DA9 3.4 78.4 1.0 CD2 F:PHE39 3.6 49.8 1.0 OP2 G:DA9 4.0 78.4 1.0 C5' G:DA9 4.0 78.4 1.0 CE2 F:TYR67 4.0 62.4 1.0 CE2 F:PHE39 4.0 49.8 1.0 OH F:TYR67 4.1 62.4 1.0 CZ F:TYR67 4.1 62.4 1.0 C2 G:CFZ8 4.4 97.0 1.0 OP1 G:DA9 4.6 78.4 1.0 C5' G:CFZ8 4.7 97.0 1.0 C5 G:CFZ8 4.7 97.0 1.0 CD2 F:TYR67 4.7 62.4 1.0 C31 G:85Y10 4.7 97.0 1.0 CG F:PHE39 4.8 49.8 1.0 C32 G:85Y10 4.8 97.0 1.0 O2 G:CFZ8 4.9 97.0 1.0 CE1 F:TYR67 4.9 62.4 1.0

Fluorine binding site 4 out of 12 in the Human Insulin Receptor Bound with A62 Dna Aptamer


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Human Insulin Receptor Bound with A62 Dna Aptamer within 5.0Å range: probe atom residue distance (Å) B Occ G:F12 b:97.0 occ:1.00 F G:AF212 0.0 97.0 1.0 C2' G:AF212 1.4 97.0 1.0 C3' G:AF212 2.3 97.0 1.0 C1' G:AF212 2.5 97.0 1.0 O3' G:AF212 2.5 97.0 1.0 OP2 G:OMG13 2.8 70.0 1.0 P G:OMG13 3.1 70.0 1.0 NH2 E:ARG554 3.2 53.7 1.0 N9 G:AF212 3.3 97.0 1.0 C4' G:AF212 3.3 97.0 1.0 O4' G:AF212 3.4 97.0 1.0 OP1 G:OMG13 3.9 70.0 1.0 C4 G:AF212 4.0 97.0 1.0 C8 G:AF212 4.1 97.0 1.0 N3 G:AF212 4.3 97.0 1.0 CZ E:ARG554 4.3 53.7 1.0 O5' G:OMG13 4.5 70.0 1.0 C5' G:AF212 4.6 97.0 1.0 OP2 G:AF212 5.0 97.0 1.0 O5' G:AF212 5.0 97.0 1.0

Fluorine binding site 5 out of 12 in the Human Insulin Receptor Bound with A62 Dna Aptamer


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Human Insulin Receptor Bound with A62 Dna Aptamer within 5.0Å range: probe atom residue distance (Å) B Occ G:F19 b:97.0 occ:1.00 F G:AF219 0.0 97.0 1.0 C2' G:AF219 1.4 97.0 1.0 C3' G:AF219 2.2 97.0 1.0 O3' G:AF219 2.3 97.0 1.0 C1' G:AF219 2.5 97.0 1.0 N9 G:AF219 3.4 97.0 1.0 P G:85Y20 3.4 64.9 1.0 O4' G:AF219 3.4 97.0 1.0 C4' G:AF219 3.4 97.0 1.0 N3 G:AF219 3.5 97.0 1.0 OP2 G:85Y20 3.5 64.9 1.0 C4 G:AF219 3.6 97.0 1.0 CD2 E:LEU486 4.1 97.0 1.0 OP1 G:85Y20 4.2 64.9 1.0 C5' G:AF219 4.3 97.0 1.0 C8 G:AF219 4.5 97.0 1.0 C2 G:AF219 4.5 97.0 1.0 C5 G:AF219 4.8 97.0 1.0 O5' G:85Y20 4.8 64.9 1.0

Fluorine binding site 6 out of 12 in the Human Insulin Receptor Bound with A62 Dna Aptamer


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Human Insulin Receptor Bound with A62 Dna Aptamer within 5.0Å range: probe atom residue distance (Å) B Occ G:F22 b:97.0 occ:1.00 F2' G:CFZ22 0.0 97.0 1.0 C2' G:CFZ22 1.4 97.0 1.0 C1' G:CFZ22 2.2 97.0 1.0 O5' G:DG23 2.5 71.2 1.0 C3' G:CFZ22 2.5 97.0 1.0 O4' G:DG23 2.6 71.2 1.0 O3' G:CFZ22 2.6 97.0 1.0 O2 G:CFZ22 3.1 97.0 1.0 C8 G:DG23 3.1 71.2 1.0 N1 G:CFZ22 3.1 97.0 1.0 P G:DG23 3.2 71.2 1.0 C4' G:CFZ22 3.3 97.0 1.0 O4' G:CFZ22 3.4 97.0 1.0 N9 G:DG23 3.4 71.2 1.0 C2 G:CFZ22 3.5 97.0 1.0 C1' G:DG23 3.5 71.2 1.0 C5' G:DG23 3.6 71.2 1.0 C4' G:DG23 3.6 71.2 1.0 N7 G:DG23 3.9 71.2 1.0 OP2 G:DG23 4.0 71.2 1.0 OP1 G:DG23 4.3 71.2 1.0 C6 G:CFZ22 4.3 97.0 1.0 C4 G:DG23 4.3 71.2 1.0 C5 G:DG23 4.6 71.2 1.0 C5' G:CFZ22 4.7 97.0 1.0 C3' G:DG23 4.8 71.2 1.0 C2' G:DG23 4.8 71.2 1.0 N3 G:CFZ22 4.9 97.0 1.0 O5' G:CFZ22 5.0 97.0 1.0 NZ F:LYS40 5.0 65.8 1.0

Fluorine binding site 7 out of 12 in the Human Insulin Receptor Bound with A62 Dna Aptamer


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Human Insulin Receptor Bound with A62 Dna Aptamer within 5.0Å range: probe atom residue distance (Å) B Occ H:F2 b:136.4 occ:1.00 F H:AF22 0.0 136.4 1.0 C2' H:AF22 1.4 136.4 1.0 C3' H:AF22 2.2 136.4 1.0 O3' H:AF22 2.3 136.4 1.0 C1' H:AF22 2.5 136.4 1.0 C4' H:AF22 3.2 136.4 1.0 O4' H:DUZ3 3.2 97.0 1.0 C30 H:85Y20 3.3 69.6 1.0 C26 H:85Y20 3.3 69.6 1.0 O4' H:AF22 3.3 136.4 1.0 N9 H:AF22 3.5 136.4 1.0 C31 H:85Y20 3.6 69.6 1.0 C27 H:85Y20 3.6 69.6 1.0 P H:DUZ3 3.7 97.0 1.0 C5' H:DUZ3 3.8 97.0 1.0 C25 H:85Y20 3.8 69.6 1.0 C32 H:85Y20 3.9 69.6 1.0 C33 H:85Y20 3.9 69.6 1.0 C4' H:DUZ3 4.0 97.0 1.0 N3 H:AF22 4.0 136.4 1.0 C4 H:AF22 4.0 136.4 1.0 C6 H:DUZ3 4.1 97.0 1.0 OP2 H:DUZ3 4.1 97.0 1.0 O5' H:DUZ3 4.3 97.0 1.0 C28 H:85Y20 4.4 69.6 1.0 C1' H:DUZ3 4.4 97.0 1.0 C5' H:AF22 4.5 136.4 1.0 C24 H:85Y20 4.5 69.6 1.0 C8 H:AF22 4.6 136.4 1.0 C29 H:85Y20 4.8 69.6 1.0 OP1 H:DUZ3 4.8 97.0 1.0 N1 H:DUZ3 4.8 97.0 1.0 O22 H:DUZ3 4.8 97.0 1.0 O5' H:AF22 4.8 136.4 1.0

Fluorine binding site 8 out of 12 in the Human Insulin Receptor Bound with A62 Dna Aptamer


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Human Insulin Receptor Bound with A62 Dna Aptamer within 5.0Å range: probe atom residue distance (Å) B Occ H:F6 b:97.0 occ:1.00 F2' H:CFZ6 0.0 97.0 1.0 C2' H:CFZ6 1.4 97.0 1.0 C1' H:CFZ6 2.2 97.0 1.0 C3' H:CFZ6 2.5 97.0 1.0 OP2 H:DG7 2.6 78.2 1.0 O3' H:CFZ6 2.9 97.0 1.0 N1 H:CFZ6 3.0 97.0 1.0 C8 H:DG7 3.1 78.2 1.0 C6 H:CFZ6 3.2 97.0 1.0 P H:DG7 3.3 78.2 1.0 N7 H:DG7 3.4 78.2 1.0 O4' H:CFZ6 3.5 97.0 1.0 C4' H:CFZ6 3.5 97.0 1.0 N9 H:DG7 4.0 78.2 1.0 O5' H:CFZ6 4.1 97.0 1.0 C5' H:CFZ6 4.2 97.0 1.0 O2P H:CFZ6 4.2 97.0 1.0 C2' H:DG7 4.3 78.2 1.0 C2 H:CFZ6 4.4 97.0 1.0 OP1 H:DG7 4.4 78.2 1.0 O5' H:DG7 4.4 78.2 1.0 C5 H:DG7 4.5 78.2 1.0 C5 H:CFZ6 4.6 97.0 1.0 C1' H:DG7 4.6 78.2 1.0 O4' H:DG7 4.7 78.2 1.0 C5' H:DG7 4.8 78.2 1.0 C4 H:DG7 4.8 78.2 1.0 O2 H:CFZ6 4.8 97.0 1.0 P H:CFZ6 4.8 97.0 1.0

Fluorine binding site 9 out of 12 in the Human Insulin Receptor Bound with A62 Dna Aptamer


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Human Insulin Receptor Bound with A62 Dna Aptamer within 5.0Å range: probe atom residue distance (Å) B Occ H:F8 b:97.0 occ:1.00 F2' H:CFZ8 0.0 97.0 1.0 C2' H:CFZ8 1.4 97.0 1.0 C1' H:CFZ8 2.2 97.0 1.0 C3' H:CFZ8 2.5 97.0 1.0 O3' H:CFZ8 2.6 97.0 1.0 O5' H:DA9 2.9 65.9 1.0 N1 H:CFZ8 3.1 97.0 1.0 C6 H:CFZ8 3.3 97.0 1.0 C4' H:CFZ8 3.3 97.0 1.0 O4' H:CFZ8 3.4 97.0 1.0 P H:DA9 3.4 65.9 1.0 CD2 E:PHE39 3.6 37.6 1.0 OP2 H:DA9 4.0 65.9 1.0 C5' H:DA9 4.0 65.9 1.0 CE2 E:PHE39 4.1 37.6 1.0 CE2 E:TYR67 4.1 57.8 1.0 CZ E:TYR67 4.1 57.8 1.0 OH E:TYR67 4.2 57.8 1.0 C2 H:CFZ8 4.4 97.0 1.0 OP1 H:DA9 4.6 65.9 1.0 CG E:PHE39 4.7 37.6 1.0 C5' H:CFZ8 4.7 97.0 1.0 C5 H:CFZ8 4.7 97.0 1.0 CD2 E:TYR67 4.7 57.8 1.0 C31 H:85Y10 4.7 84.6 1.0 C32 H:85Y10 4.8 84.6 1.0 CE1 E:TYR67 4.8 57.8 1.0 O2 H:CFZ8 4.9 97.0 1.0 CB E:PHE39 4.9 37.6 1.0

Fluorine binding site 10 out of 12 in the Human Insulin Receptor Bound with A62 Dna Aptamer


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Human Insulin Receptor Bound with A62 Dna Aptamer within 5.0Å range: probe atom residue distance (Å) B Occ H:F12 b:97.0 occ:1.00 F H:AF212 0.0 97.0 1.0 C2' H:AF212 1.4 97.0 1.0 C3' H:AF212 2.3 97.0 1.0 C1' H:AF212 2.5 97.0 1.0 O3' H:AF212 2.5 97.0 1.0 OP2 H:OMG13 2.8 85.8 1.0 P H:OMG13 3.1 85.8 1.0 NH1 F:ARG554 3.3 61.1 1.0 N9 H:AF212 3.3 97.0 1.0 C4' H:AF212 3.3 97.0 1.0 O4' H:AF212 3.4 97.0 1.0 OP1 H:OMG13 3.9 85.8 1.0 C4 H:AF212 4.0 97.0 1.0 C8 H:AF212 4.1 97.0 1.0 CZ F:ARG554 4.2 61.1 1.0 N3 H:AF212 4.3 97.0 1.0 O5' H:OMG13 4.5 85.8 1.0 NH2 F:ARG554 4.5 61.1 1.0 C5' H:AF212 4.6 97.0 1.0 OP2 H:AF212 5.0 97.0 1.0 O5' H:AF212 5.0 97.0 1.0

J.Kim, N.O.Yunn, M.Park, J.Kim, S.Park, Y.Kim, J.Noh, S.H.Ryu, Y.Cho. Functional Selectivity of Insulin Receptor Revealed By Aptamer-Trapped Receptor Structures Nat Commun V. 13 6500 2022.
ISSN: ESSN 2041-1723
DOI: 10.1038/S41467-022-34292-8