Fluorine in PDB 7z2h: Cryo-Em Structure of Nnrti Resistant M184I/E138K Mutant Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine
Enzymatic activity of Cryo-Em Structure of Nnrti Resistant M184I/E138K Mutant Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine
All present enzymatic activity of Cryo-Em Structure of Nnrti Resistant M184I/E138K Mutant Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine:
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13;
2.7.7.49; 2.7.7.7; 3.1.13.2; 3.1.26.13;
Other elements in 7z2h:
The structure of Cryo-Em Structure of Nnrti Resistant M184I/E138K Mutant Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Cryo-Em Structure of Nnrti Resistant M184I/E138K Mutant Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine
(pdb code 7z2h). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Cryo-Em Structure of Nnrti Resistant M184I/E138K Mutant Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine, PDB code: 7z2h:
Jump to Fluorine binding site number: 1; 2; 3;
In total 3 binding sites of Fluorine where determined in the Cryo-Em Structure of Nnrti Resistant M184I/E138K Mutant Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine, PDB code: 7z2h:
Jump to Fluorine binding site number: 1; 2; 3;
Fluorine binding site 1 out of 3 in 7z2h
Go back to
Fluorine Binding Sites List in 7z2h
Fluorine binding site 1 out
of 3 in the Cryo-Em Structure of Nnrti Resistant M184I/E138K Mutant Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Cryo-Em Structure of Nnrti Resistant M184I/E138K Mutant Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine within 5.0Å range:
|
Fluorine binding site 2 out of 3 in 7z2h
Go back to
Fluorine Binding Sites List in 7z2h
Fluorine binding site 2 out
of 3 in the Cryo-Em Structure of Nnrti Resistant M184I/E138K Mutant Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Cryo-Em Structure of Nnrti Resistant M184I/E138K Mutant Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine within 5.0Å range:
|
Fluorine binding site 3 out of 3 in 7z2h
Go back to
Fluorine Binding Sites List in 7z2h
Fluorine binding site 3 out
of 3 in the Cryo-Em Structure of Nnrti Resistant M184I/E138K Mutant Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 3 of Cryo-Em Structure of Nnrti Resistant M184I/E138K Mutant Hiv-1 Reverse Transcriptase with A Dna Aptamer in Complex with Doravirine within 5.0Å range:
|
Reference:
A.K.Singh,
B.De Wijngaert,
M.Bijnens,
K.Uyttersprot,
H.Nguyen,
S.E.Martinez,
D.Schols,
P.Herdewijn,
C.Pannecouque,
E.Arnold,
K.Das.
Cryo-Em Structures of Wild-Type and E138K/M184I Mutant Hiv-1 Rt/Dna Complexed with Inhibitors Doravirine and Rilpivirine. Proc.Natl.Acad.Sci.Usa V. 119 60119 2022.
ISSN: ESSN 1091-6490
PubMed: 35858448
DOI: 10.1073/PNAS.2203660119
Page generated: Wed Apr 5 01:57:15 2023
ISSN: ESSN 1091-6490
PubMed: 35858448
DOI: 10.1073/PNAS.2203660119
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