Fluorine in PDB 8am0: Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib)
Enzymatic activity of Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib)
All present enzymatic activity of Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib):
2.7.1.137; 2.7.1.153; 2.7.11.1;
2.7.1.137; 2.7.1.153; 2.7.11.1;
Protein crystallography data
The structure of Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib), PDB code: 8am0
was solved by
M.Goncalves,
J.L.Johnson,
K.M.Roewer,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 47.39 / 2.82 |
| Space group | P 21 21 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 99.81, 107.68, 136.3, 90, 90, 90 |
| R / Rfree (%) | 28.5 / 30 |
Other elements in 8am0:
The structure of Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib) also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib)
(pdb code 8am0). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib), PDB code: 8am0:
Jump to Fluorine binding site number: 1; 2;
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib), PDB code: 8am0:
Jump to Fluorine binding site number: 1; 2;
Fluorine binding site 1 out of 2 in 8am0
Go back to
Fluorine Binding Sites List in 8am0
Fluorine binding site 1 out
of 2 in the Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 1 of Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib) within 5.0Å range:
|
Fluorine binding site 2 out of 2 in 8am0
Go back to
Fluorine Binding Sites List in 8am0
Fluorine binding site 2 out
of 2 in the Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib)
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Fluorine with other atoms in the F binding
site number 2 of Crystal Structure of Human T1061E PI3KALPHA in Complex with Its Regulatory Subunit and the Inhibitor Gdc-0077 (Inavolisib) within 5.0Å range:
|
Reference:
T.Lin,
S.Ramsamooj,
K.Liberatore,
L.Lantier,
N.Vasan,
K.Karukurichi,
S.Hwang,
E.A.Kesicki,
E.R.Kastenhuber,
T.Wiederhold,
T.M.Yaron,
M.Zhu,
Y.Ma,
M.N.Paddock,
G.Zhang,
B.D.Hopkins,
O.Mcguinness,
R.E.Schwartz,
L.C.Cantley,
J.L.Johnson,
M.D.Goncalves.
Epinephrine Inhibits PI3K Alpha Via the Hippo Kinases To Be Published.
Page generated: Fri Aug 2 16:31:28 2024
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