Fluorine in PDB 8axw: The Structure of Mouse Asterc (GRAMD1C) with Ezetimibe

The structure of The Structure of Mouse Asterc (GRAMD1C) with Ezetimibe, PDB code: 8axw was solved by L.Fairall, X.Xiao, L.Burger, P.Tontonoz, J.W.R.Schwabe, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.94 / 1.60
Space group	P 41 21 2
Cell size a, b, c (Å), α, β, γ (°)	49.625, 49.625, 144.775, 90, 90, 90
R / Rfree (%)	17.2 / 20.6

The structure of The Structure of Mouse Asterc (GRAMD1C) with Ezetimibe also contains other interesting chemical elements:

Chlorine

(Cl)

1 atom

The binding sites of Fluorine atom in the The Structure of Mouse Asterc (GRAMD1C) with Ezetimibe (pdb code 8axw). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the The Structure of Mouse Asterc (GRAMD1C) with Ezetimibe, PDB code: 8axw:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the The Structure of Mouse Asterc (GRAMD1C) with Ezetimibe


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of The Structure of Mouse Asterc (GRAMD1C) with Ezetimibe within 5.0Å range: probe atom residue distance (Å) B Occ A:F609 b:41.9 occ:1.00 F1 A:H56609 0.0 41.9 1.0 C6 A:H56609 1.3 40.5 1.0 C5 A:H56609 2.3 29.4 1.0 C7 A:H56609 2.4 41.7 1.0 H5 A:H56609 2.5 35.3 1.0 H7 A:H56609 2.6 50.1 1.0 HG23 A:THR423 2.6 26.4 1.0 HE2 A:PHE432 2.7 25.7 1.0 O A:HOH747 2.7 25.6 1.0 HG21 A:THR423 2.9 26.4 1.0 CG2 A:THR423 3.2 22.0 1.0 CE2 A:PHE432 3.4 21.4 1.0 HZ A:PHE432 3.5 24.6 1.0 C8 A:H56609 3.6 31.7 1.0 C4 A:H56609 3.6 28.9 1.0 HG1 A:THR434 3.7 29.7 1.0 HG22 A:THR423 3.7 26.4 1.0 CZ A:PHE432 3.9 20.5 1.0 HG1 A:THR423 4.0 23.9 1.0 OG1 A:THR434 4.0 24.7 1.0 C3 A:H56609 4.1 22.2 1.0 HG12 A:VAL421 4.2 25.2 1.0 OG1 A:THR423 4.4 19.9 1.0 CB A:THR423 4.4 21.8 1.0 H4 A:H56609 4.4 34.6 1.0 H8 A:H56609 4.4 38.1 1.0 CD2 A:PHE432 4.6 19.8 1.0 H A:THR423 4.6 17.3 1.0 HO1 A:PGE608 4.6 41.9 1.0 O A:HOH768 4.7 18.4 1.0 HD2 A:PHE432 4.7 23.7 1.0 HG11 A:VAL421 4.9 25.2 1.0 N A:THR423 4.9 14.4 1.0 HB A:THR434 4.9 22.9 1.0 HG21 A:VAL426 5.0 20.6 1.0 CG1 A:VAL421 5.0 21.0 1.0

Fluorine binding site 2 out of 2 in the The Structure of Mouse Asterc (GRAMD1C) with Ezetimibe


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of The Structure of Mouse Asterc (GRAMD1C) with Ezetimibe within 5.0Å range: probe atom residue distance (Å) B Occ A:F609 b:38.6 occ:1.00 F2 A:H56609 0.0 38.6 1.0 C16 A:H56609 1.3 23.7 1.0 HG21 A:VAL365 2.4 23.5 1.0 C17 A:H56609 2.4 25.2 1.0 C15 A:H56609 2.4 27.5 1.0 HB2 A:ALA357 2.5 25.1 1.0 H17 A:H56609 2.6 30.3 1.0 H15 A:H56609 2.6 33.0 1.0 O A:HOH835 2.8 28.8 1.0 HG11 A:VAL365 3.0 25.4 1.0 CG2 A:VAL365 3.2 19.6 1.0 HG22 A:VAL365 3.2 23.5 1.0 HB1 A:ALA357 3.2 25.1 1.0 CB A:ALA357 3.2 20.9 1.0 HG22 A:ILE362 3.6 19.6 1.0 O A:HOH864 3.6 30.8 1.0 HG21 A:ILE362 3.6 19.6 1.0 C18 A:H56609 3.6 25.5 1.0 C14 A:H56609 3.7 25.8 1.0 HE3 A:MET353 3.7 50.5 1.0 CG1 A:VAL365 3.7 21.2 1.0 HB3 A:ALA357 3.7 25.1 1.0 HG23 A:VAL365 3.9 23.5 1.0 HG13 A:VAL365 3.9 25.4 1.0 HE1 A:MET382 3.9 27.7 1.0 CB A:VAL365 4.0 20.2 1.0 CG2 A:ILE362 4.1 16.3 1.0 O A:MET353 4.1 20.1 1.0 C13 A:H56609 4.2 26.5 1.0 HB3 A:MET353 4.2 20.3 1.0 HB A:VAL365 4.3 24.3 1.0 HA A:ALA357 4.3 23.4 1.0 O A:HOH868 4.3 26.4 1.0 HB A:ILE362 4.4 18.1 1.0 CA A:ALA357 4.4 19.4 1.0 H18 A:H56609 4.4 30.6 1.0 H14 A:H56609 4.4 31.0 1.0 CE A:MET353 4.5 42.1 1.0 HE2 A:MET353 4.5 50.5 1.0 HE2 A:MET382 4.5 27.7 1.0 HG12 A:VAL365 4.6 25.4 1.0 HD13 A:ILE362 4.6 28.6 1.0 CE A:MET382 4.7 23.1 1.0 H A:ALA357 4.7 21.7 1.0 HE1 A:MET353 4.7 50.5 1.0 CB A:ILE362 4.8 15.1 1.0 HD12 A:ILE362 4.8 28.6 1.0 HG23 A:ILE362 4.9 19.6 1.0 C A:MET353 5.0 18.3 1.0 N A:ALA357 5.0 18.1 1.0

L.Fairall, L.Burger, P.Tontonoz, J.W.R.Schwabe. The Structure of Mouse Asterc (GRAMD1C) with Ezetimibe To Be Published.