Fluorine in PDB 8ayl: Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059

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Binding sites:

The binding sites of Fluorine atom in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 (pdb code 8ayl). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 14 binding sites of Fluorine where determined in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059, PDB code: 8ayl:
Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9; 10;

Fluorine binding site 1 out of 14 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ B:F901 b:60.1 occ:1.00 FAF B:ZK1901 0.0 60.1 1.0 CAZ B:ZK1901 1.4 60.1 1.0 FAG B:ZK1901 2.2 60.1 1.0 FAH B:ZK1901 2.2 60.1 1.0 CAS B:ZK1901 2.4 60.1 1.0 HAMA B:ZK1901 2.4 60.1 1.0 HG2 B:GLU402 3.1 68.8 1.0 CAR B:ZK1901 3.1 60.1 1.0 CAM B:ZK1901 3.2 60.1 1.0 HAM B:ZK1901 3.3 60.1 1.0 CAJ B:ZK1901 3.4 60.1 1.0 HAN B:ZK1901 3.4 60.1 1.0 NAX B:ZK1901 3.6 60.1 1.0 HE2 B:TYR405 3.6 66.4 1.0 HAJ B:ZK1901 3.7 60.1 1.0 HB2 B:MET708 3.8 58.5 1.0 CG B:GLU402 3.9 68.8 1.0 HG3 B:GLU402 3.9 68.8 1.0 CAN B:ZK1901 4.0 60.1 1.0 OE2 B:GLU402 4.1 68.8 1.0 CD B:GLU402 4.3 68.8 1.0 HE2 B:MET708 4.3 58.5 1.0 HALA B:ZK1901 4.3 60.1 1.0 HH B:TYR732 4.3 50.6 1.0 OH B:TYR732 4.4 50.6 1.0 HAK B:ZK1901 4.4 60.1 1.0 HB2 B:PRO478 4.4 62.6 1.0 CAK B:ZK1901 4.4 60.1 1.0 SD B:MET708 4.5 58.5 1.0 CAI B:ZK1901 4.5 60.1 1.0 CE2 B:TYR405 4.5 66.4 1.0 HD2 B:TYR405 4.6 66.4 1.0 CB B:MET708 4.7 58.5 1.0 CAV B:ZK1901 4.7 60.1 1.0 CAL B:ZK1901 4.7 60.1 1.0 HG2 B:MET708 4.7 58.5 1.0 HG3 B:PRO478 4.8 62.6 1.0 HANA B:ZK1901 4.8 60.1 1.0 CE B:MET708 4.8 58.5 1.0 HB2 B:GLU705 4.8 52.0 1.0 CG B:MET708 4.9 58.5 1.0 HH B:TYR405 4.9 66.4 1.0 HE1 B:MET708 5.0 58.5 1.0

Fluorine binding site 2 out of 14 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ B:F901 b:60.1 occ:1.00 FAG B:ZK1901 0.0 60.1 1.0 CAZ B:ZK1901 1.4 60.1 1.0 FAF B:ZK1901 2.2 60.1 1.0 FAH B:ZK1901 2.2 60.1 1.0 OH B:TYR732 2.3 50.6 1.0 CAS B:ZK1901 2.4 60.1 1.0 HAJ B:ZK1901 2.4 60.1 1.0 CAJ B:ZK1901 2.5 60.1 1.0 HH B:TYR732 2.6 50.6 1.0 HB2 B:PRO478 3.0 62.6 1.0 CZ B:TYR732 3.1 50.6 1.0 HE2 B:TYR405 3.4 66.4 1.0 CAR B:ZK1901 3.6 60.1 1.0 CB B:PRO478 3.8 62.6 1.0 HE1 B:TYR732 3.8 50.6 1.0 CE1 B:TYR732 3.8 50.6 1.0 CAV B:ZK1901 3.8 60.1 1.0 CE2 B:TYR732 3.9 50.6 1.0 HB3 B:PRO478 3.9 62.6 1.0 HE2 B:TYR732 3.9 50.6 1.0 HAMA B:ZK1901 4.0 60.1 1.0 HAM B:ZK1901 4.1 60.1 1.0 CE2 B:TYR405 4.2 66.4 1.0 HH B:TYR405 4.2 66.4 1.0 OG1 B:THR707 4.3 53.6 1.0 O B:PRO478 4.4 62.6 1.0 CAM B:ZK1901 4.4 60.1 1.0 HG1 B:THR707 4.4 53.6 1.0 HG3 B:PRO478 4.4 62.6 1.0 HG2 B:GLU402 4.5 68.8 1.0 HG2 B:PRO478 4.5 62.6 1.0 CG B:PRO478 4.5 62.6 1.0 HNAP B:ZK1901 4.5 60.1 1.0 HG2 B:GLU705 4.6 52.0 1.0 CAI B:ZK1901 4.6 60.1 1.0 NAX B:ZK1901 4.6 60.1 1.0 NAP B:ZK1901 4.7 60.1 1.0 HB3 B:GLU705 4.7 52.0 1.0 CAW B:ZK1901 4.7 60.1 1.0 HB2 B:GLU705 4.7 52.0 1.0 OH B:TYR405 4.8 66.4 1.0 HD11 B:LEU498 4.8 46.7 1.0 HD2 B:TYR405 4.8 66.4 1.0 CZ B:TYR405 4.9 66.4 1.0 HD13 B:LEU498 4.9 46.7 1.0 CD2 B:TYR405 5.0 66.4 1.0 HB2 B:MET708 5.0 58.5 1.0 CD1 B:TYR732 5.0 50.6 1.0 CA B:PRO478 5.0 62.6 1.0

Fluorine binding site 3 out of 14 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ B:F901 b:60.1 occ:1.00 FAH B:ZK1901 0.0 60.1 1.0 CAZ B:ZK1901 1.4 60.1 1.0 FAF B:ZK1901 2.2 60.1 1.0 FAG B:ZK1901 2.2 60.1 1.0 CAS B:ZK1901 2.4 60.1 1.0 HAJ B:ZK1901 2.4 60.1 1.0 CAJ B:ZK1901 2.5 60.1 1.0 HG2 B:GLU402 2.6 68.8 1.0 HB2 B:PRO478 2.6 62.6 1.0 HG3 B:PRO478 2.8 62.6 1.0 HG2 B:PRO478 2.9 62.6 1.0 CG B:PRO478 3.1 62.6 1.0 CB B:PRO478 3.2 62.6 1.0 HH B:TYR450 3.3 69.2 1.0 HE2 B:TYR405 3.4 66.4 1.0 OH B:TYR450 3.4 69.2 1.0 HB3 B:PRO478 3.5 62.6 1.0 CG B:GLU402 3.5 68.8 1.0 HD2 B:TYR405 3.6 66.4 1.0 CAR B:ZK1901 3.6 60.1 1.0 CAV B:ZK1901 3.8 60.1 1.0 HG3 B:GLU402 3.9 68.8 1.0 HB3 B:GLU402 4.0 68.8 1.0 CE2 B:TYR405 4.0 66.4 1.0 O B:PRO478 4.1 62.6 1.0 CD2 B:TYR405 4.1 66.4 1.0 HAN B:ZK1901 4.2 60.1 1.0 CB B:GLU402 4.2 68.8 1.0 HAMA B:ZK1901 4.3 60.1 1.0 CZ B:TYR450 4.4 69.2 1.0 CD B:GLU402 4.4 68.8 1.0 HB2 B:GLU402 4.4 68.8 1.0 OH B:TYR732 4.4 50.6 1.0 HNAP B:ZK1901 4.5 60.1 1.0 CA B:PRO478 4.5 62.6 1.0 HE1 B:TYR450 4.6 69.2 1.0 CD B:PRO478 4.6 62.6 1.0 CAI B:ZK1901 4.6 60.1 1.0 NAP B:ZK1901 4.6 60.1 1.0 NAX B:ZK1901 4.7 60.1 1.0 HH B:TYR732 4.7 50.6 1.0 CAW B:ZK1901 4.7 60.1 1.0 C B:PRO478 4.8 62.6 1.0 CE1 B:TYR450 4.8 69.2 1.0 CAM B:ZK1901 4.9 60.1 1.0 OE2 B:GLU402 4.9 68.8 1.0 CZ B:TYR732 4.9 50.6 1.0 CAN B:ZK1901 4.9 60.1 1.0 HD2 B:PRO478 5.0 62.6 1.0 HAM B:ZK1901 5.0 60.1 1.0 HD3 B:PRO478 5.0 62.6 1.0 OE1 B:GLU402 5.0 68.8 1.0

Fluorine binding site 4 out of 14 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ J:F501 b:22.8 occ:1.00 F1 J:OIJ501 0.0 22.8 1.0 C21 J:OIJ501 1.4 22.8 1.0 C20 J:OIJ501 2.4 22.8 1.0 C22 J:OIJ501 2.4 22.8 1.0 HG J:LEU210 3.0 26.7 1.0 HD21 J:LEU210 3.3 26.7 1.0 C23 J:OIJ501 3.6 22.8 1.0 C19 J:OIJ501 3.6 22.8 1.0 CG J:LEU210 3.8 26.7 1.0 CD2 J:LEU210 3.8 26.7 1.0 HB3 J:TYR206 3.8 24.6 1.0 HD23 J:LEU210 3.9 26.7 1.0 HD12 J:ILE213 4.0 27.3 1.0 O J:TYR206 4.1 24.6 1.0 C18 J:OIJ501 4.1 22.8 1.0 HD11 J:ILE213 4.2 27.3 1.0 HC1 A:PLM901 4.2 27.8 1.0 HD11 J:LEU210 4.2 26.7 1.0 HA J:TYR206 4.3 24.6 1.0 H J:LEU210 4.4 26.7 1.0 HA3 J:GLY209 4.4 25.2 1.0 HA J:LEU210 4.5 26.7 1.0 CD1 J:LEU210 4.5 26.7 1.0 N J:LEU210 4.5 26.7 1.0 HD1 J:TYR206 4.5 24.6 1.0 CD1 J:ILE213 4.5 27.3 1.0 HZ A:PHE527 4.5 20.6 1.0 HE1 A:PLM901 4.6 27.8 1.0 HD12 J:LEU210 4.7 26.7 1.0 CB J:TYR206 4.7 24.6 1.0 HA2 A:PLM901 4.7 27.8 1.0 HD22 J:LEU210 4.8 26.7 1.0 CA J:TYR206 4.8 24.6 1.0 C J:GLY209 4.8 25.2 1.0 CA J:LEU210 4.9 26.7 1.0 C J:TYR206 4.9 24.6 1.0 CB J:LEU210 4.9 26.7 1.0 HD13 J:ILE213 4.9 27.3 1.0

Fluorine binding site 5 out of 14 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ I:F501 b:22.7 occ:1.00 F1 I:OIJ501 0.0 22.7 1.0 C21 I:OIJ501 1.4 22.7 1.0 C20 I:OIJ501 2.4 22.7 1.0 C22 I:OIJ501 2.4 22.7 1.0 HG I:LEU210 3.0 26.6 1.0 HD21 I:LEU210 3.3 26.6 1.0 C23 I:OIJ501 3.6 22.7 1.0 C19 I:OIJ501 3.6 22.7 1.0 CG I:LEU210 3.8 26.6 1.0 CD2 I:LEU210 3.8 26.6 1.0 HB3 I:TYR206 3.8 24.4 1.0 HD23 I:LEU210 3.9 26.6 1.0 HD12 I:ILE213 4.0 27.1 1.0 O I:TYR206 4.1 24.4 1.0 C18 I:OIJ501 4.1 22.7 1.0 HD11 I:ILE213 4.2 27.1 1.0 HC1 C:PLM901 4.2 27.8 1.0 HD11 I:LEU210 4.2 26.6 1.0 HA I:TYR206 4.3 24.4 1.0 H I:LEU210 4.4 26.6 1.0 HA3 I:GLY209 4.4 25.1 1.0 HA I:LEU210 4.5 26.6 1.0 CD1 I:LEU210 4.5 26.6 1.0 N I:LEU210 4.5 26.6 1.0 HZ C:PHE527 4.5 20.8 1.0 HD1 I:TYR206 4.5 24.4 1.0 CD1 I:ILE213 4.5 27.1 1.0 HE1 C:PLM901 4.6 27.8 1.0 HD12 I:LEU210 4.7 26.6 1.0 CB I:TYR206 4.7 24.4 1.0 HA2 C:PLM901 4.7 27.8 1.0 HD22 I:LEU210 4.8 26.6 1.0 CA I:TYR206 4.8 24.4 1.0 C I:GLY209 4.8 25.1 1.0 CA I:LEU210 4.9 26.6 1.0 C I:TYR206 4.9 24.4 1.0 CB I:LEU210 4.9 26.6 1.0 HD13 I:ILE213 4.9 27.1 1.0

Fluorine binding site 6 out of 14 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 6 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ A:F902 b:54.9 occ:1.00 FAF A:ZK1902 0.0 54.9 1.0 CAZ A:ZK1902 1.4 54.9 1.0 FAG A:ZK1902 2.2 54.9 1.0 FAH A:ZK1902 2.2 54.9 1.0 HAJ A:ZK1902 2.3 54.9 1.0 CAS A:ZK1902 2.4 54.9 1.0 CAJ A:ZK1902 2.5 54.9 1.0 HG2 A:GLU398 2.6 53.6 1.0 HG3 A:PRO474 2.6 42.7 1.0 HH A:TYR446 2.8 56.3 1.0 HG3 A:GLU398 2.8 53.6 1.0 HG2 A:PRO474 2.9 42.7 1.0 CG A:PRO474 3.1 42.7 1.0 CG A:GLU398 3.1 53.6 1.0 HB2 A:PRO474 3.1 42.7 1.0 OH A:TYR446 3.2 56.3 1.0 HE1 A:TYR401 3.4 47.1 1.0 CB A:PRO474 3.5 42.7 1.0 HB3 A:GLU398 3.5 53.6 1.0 CAR A:ZK1902 3.6 54.9 1.0 HD1 A:TYR401 3.7 47.1 1.0 HB3 A:PRO474 3.7 42.7 1.0 CE1 A:TYR401 3.8 47.1 1.0 CAV A:ZK1902 3.8 54.9 1.0 CB A:GLU398 3.9 53.6 1.0 CD1 A:TYR401 3.9 47.1 1.0 HE3 A:MET704 3.9 51.5 1.0 HE2 A:TYR446 4.1 56.3 1.0 HB2 A:GLU398 4.2 53.6 1.0 CZ A:TYR446 4.2 56.3 1.0 CD A:GLU398 4.3 53.6 1.0 HNAP A:ZK1902 4.4 54.9 1.0 CD A:PRO474 4.5 42.7 1.0 CE2 A:TYR446 4.5 56.3 1.0 HH A:TYR728 4.6 36.8 1.0 NAP A:ZK1902 4.6 54.9 1.0 CAI A:ZK1902 4.6 54.9 1.0 NAX A:ZK1902 4.6 54.9 1.0 CAW A:ZK1902 4.7 54.9 1.0 OH A:TYR728 4.7 36.8 1.0 HD2 A:PRO474 4.7 42.7 1.0 CZ A:TYR401 4.7 47.1 1.0 HD3 A:PRO474 4.8 42.7 1.0 HAMA A:ZK1902 4.8 54.9 1.0 OE2 A:GLU398 4.8 53.6 1.0 CE A:MET704 4.9 51.5 1.0 O A:PRO474 4.9 42.7 1.0 CA A:PRO474 4.9 42.7 1.0 HH A:TYR401 4.9 47.1 1.0 CG A:TYR401 5.0 47.1 1.0

Fluorine binding site 7 out of 14 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 7 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ A:F902 b:54.9 occ:1.00 FAG A:ZK1902 0.0 54.9 1.0 CAZ A:ZK1902 1.4 54.9 1.0 FAF A:ZK1902 2.2 54.9 1.0 FAH A:ZK1902 2.2 54.9 1.0 CAS A:ZK1902 2.3 54.9 1.0 HE3 A:MET704 2.4 51.5 1.0 HG2 A:GLU398 2.9 53.6 1.0 HG3 A:GLU398 2.9 53.6 1.0 HG2 A:MET704 3.0 51.5 1.0 CAR A:ZK1902 3.1 54.9 1.0 CE A:MET704 3.3 51.5 1.0 CG A:GLU398 3.3 53.6 1.0 HE1 A:TYR401 3.3 47.1 1.0 CAJ A:ZK1902 3.4 54.9 1.0 NAX A:ZK1902 3.4 54.9 1.0 CG A:MET704 3.6 51.5 1.0 SD A:MET704 3.6 51.5 1.0 HG3 A:MET704 3.7 51.5 1.0 HAJ A:ZK1902 3.7 54.9 1.0 HE1 A:MET704 3.8 51.5 1.0 CD A:GLU398 3.8 53.6 1.0 HE2 A:MET704 3.9 51.5 1.0 HAM A:ZK1902 4.0 54.9 1.0 OE2 A:GLU398 4.1 53.6 1.0 CAM A:ZK1902 4.1 54.9 1.0 HAMA A:ZK1902 4.1 54.9 1.0 CE1 A:TYR401 4.1 47.1 1.0 HANA A:ZK1902 4.2 54.9 1.0 CAN A:ZK1902 4.3 54.9 1.0 HD1 A:TYR401 4.3 47.1 1.0 HAN A:ZK1902 4.4 54.9 1.0 CAI A:ZK1902 4.4 54.9 1.0 HH A:TYR446 4.5 56.3 1.0 OE1 A:GLU398 4.5 53.6 1.0 HG3 A:PRO474 4.5 42.7 1.0 HH A:TYR728 4.5 36.8 1.0 OH A:TYR446 4.6 56.3 1.0 CD1 A:TYR401 4.7 47.1 1.0 CB A:GLU398 4.7 53.6 1.0 CAV A:ZK1902 4.7 54.9 1.0 HH A:TYR401 4.7 47.1 1.0 HB3 A:GLU398 4.7 53.6 1.0 OG1 A:THR703 4.8 46.0 1.0 OH A:TYR728 4.9 36.8 1.0 HB2 A:PRO474 4.9 42.7 1.0 HAI A:ZK1902 5.0 54.9 1.0 O A:ASP399 5.0 53.8 1.0 CB A:MET704 5.0 51.5 1.0

Fluorine binding site 8 out of 14 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 8 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ A:F902 b:54.9 occ:1.00 FAH A:ZK1902 0.0 54.9 1.0 CAZ A:ZK1902 1.4 54.9 1.0 FAG A:ZK1902 2.2 54.9 1.0 FAF A:ZK1902 2.2 54.9 1.0 CAS A:ZK1902 2.4 54.9 1.0 HH A:TYR728 2.5 36.8 1.0 HAJ A:ZK1902 2.6 54.9 1.0 CAJ A:ZK1902 2.6 54.9 1.0 OH A:TYR728 2.8 36.8 1.0 HE1 A:TYR401 3.1 47.1 1.0 HB2 A:PRO474 3.3 42.7 1.0 HE3 A:MET704 3.4 51.5 1.0 CAR A:ZK1902 3.6 54.9 1.0 HE2 A:TYR728 3.6 36.8 1.0 CZ A:TYR728 3.6 36.8 1.0 HH A:TYR401 3.6 47.1 1.0 HB3 A:PRO474 3.6 42.7 1.0 CE1 A:TYR401 3.7 47.1 1.0 HG3 A:PRO474 3.8 42.7 1.0 CB A:PRO474 3.8 42.7 1.0 CE2 A:TYR728 3.9 36.8 1.0 CAV A:ZK1902 3.9 54.9 1.0 OG1 A:THR703 3.9 46.0 1.0 OH A:TYR401 4.0 47.1 1.0 HG2 A:MET704 4.1 51.5 1.0 HG1 A:THR703 4.1 46.0 1.0 CG A:PRO474 4.2 42.7 1.0 CZ A:TYR401 4.2 47.1 1.0 HG2 A:PRO474 4.3 42.7 1.0 CE A:MET704 4.3 51.5 1.0 HG2 A:GLU398 4.4 53.6 1.0 HG3 A:GLU398 4.4 53.6 1.0 NAX A:ZK1902 4.5 54.9 1.0 CD1 A:TYR401 4.5 47.1 1.0 HE2 A:MET704 4.6 51.5 1.0 CAI A:ZK1902 4.6 54.9 1.0 HD1 A:TYR401 4.6 47.1 1.0 CE1 A:TYR728 4.6 36.8 1.0 HNAP A:ZK1902 4.6 54.9 1.0 HAN A:ZK1902 4.7 54.9 1.0 CAW A:ZK1902 4.7 54.9 1.0 NAP A:ZK1902 4.8 54.9 1.0 HE1 A:TYR728 4.8 36.8 1.0 HH A:TYR446 4.8 56.3 1.0 HE1 A:MET704 4.9 51.5 1.0 CG A:GLU398 4.9 53.6 1.0 CG A:MET704 4.9 51.5 1.0 HD13 A:LEU494 4.9 38.7 1.0

Fluorine binding site 9 out of 14 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 9 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ D:F901 b:60.0 occ:1.00 FAF D:ZK1901 0.0 60.0 1.0 CAZ D:ZK1901 1.4 60.0 1.0 FAG D:ZK1901 2.2 60.0 1.0 FAH D:ZK1901 2.2 60.0 1.0 CAS D:ZK1901 2.4 60.0 1.0 HAMA D:ZK1901 2.4 60.0 1.0 HG2 D:GLU402 3.1 69.0 1.0 CAR D:ZK1901 3.1 60.0 1.0 CAM D:ZK1901 3.2 60.0 1.0 HAM D:ZK1901 3.3 60.0 1.0 CAJ D:ZK1901 3.4 60.0 1.0 HAN D:ZK1901 3.5 60.0 1.0 NAX D:ZK1901 3.6 60.0 1.0 HE2 D:TYR405 3.6 66.5 1.0 HAJ D:ZK1901 3.7 60.0 1.0 HB2 D:MET708 3.8 58.4 1.0 CG D:GLU402 3.9 69.0 1.0 HG3 D:GLU402 3.9 69.0 1.0 CAN D:ZK1901 4.0 60.0 1.0 OE2 D:GLU402 4.1 69.0 1.0 CD D:GLU402 4.3 69.0 1.0 HE2 D:MET708 4.3 58.4 1.0 HALA D:ZK1901 4.3 60.0 1.0 HH D:TYR732 4.3 50.2 1.0 OH D:TYR732 4.3 50.2 1.0 HAK D:ZK1901 4.4 60.0 1.0 HB2 D:PRO478 4.4 62.7 1.0 CAK D:ZK1901 4.4 60.0 1.0 SD D:MET708 4.5 58.4 1.0 CAI D:ZK1901 4.5 60.0 1.0 CE2 D:TYR405 4.5 66.5 1.0 HD2 D:TYR405 4.6 66.5 1.0 CB D:MET708 4.7 58.4 1.0 CAV D:ZK1901 4.7 60.0 1.0 CAL D:ZK1901 4.7 60.0 1.0 HG2 D:MET708 4.7 58.4 1.0 HG3 D:PRO478 4.8 62.7 1.0 HANA D:ZK1901 4.8 60.0 1.0 CE D:MET708 4.8 58.4 1.0 HB2 D:GLU705 4.8 51.7 1.0 CG D:MET708 4.9 58.4 1.0 HH D:TYR405 4.9 66.5 1.0

Fluorine binding site 10 out of 14 in the Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 10 of Resting State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ D:F901 b:60.0 occ:1.00 FAG D:ZK1901 0.0 60.0 1.0 CAZ D:ZK1901 1.4 60.0 1.0 FAF D:ZK1901 2.2 60.0 1.0 FAH D:ZK1901 2.2 60.0 1.0 OH D:TYR732 2.3 50.2 1.0 CAS D:ZK1901 2.4 60.0 1.0 HAJ D:ZK1901 2.4 60.0 1.0 CAJ D:ZK1901 2.5 60.0 1.0 HH D:TYR732 2.6 50.2 1.0 HB2 D:PRO478 3.0 62.7 1.0 CZ D:TYR732 3.1 50.2 1.0 HE2 D:TYR405 3.4 66.5 1.0 CAR D:ZK1901 3.6 60.0 1.0 CB D:PRO478 3.8 62.7 1.0 HE1 D:TYR732 3.8 50.2 1.0 CE1 D:TYR732 3.8 50.2 1.0 CAV D:ZK1901 3.8 60.0 1.0 CE2 D:TYR732 3.9 50.2 1.0 HE2 D:TYR732 3.9 50.2 1.0 HB3 D:PRO478 3.9 62.7 1.0 HAMA D:ZK1901 4.0 60.0 1.0 HAM D:ZK1901 4.1 60.0 1.0 CE2 D:TYR405 4.2 66.5 1.0 HH D:TYR405 4.2 66.5 1.0 OG1 D:THR707 4.3 53.3 1.0 O D:PRO478 4.4 62.7 1.0 CAM D:ZK1901 4.4 60.0 1.0 HG1 D:THR707 4.4 53.3 1.0 HG3 D:PRO478 4.4 62.7 1.0 HG2 D:GLU402 4.5 69.0 1.0 HG2 D:PRO478 4.5 62.7 1.0 CG D:PRO478 4.5 62.7 1.0 HNAP D:ZK1901 4.5 60.0 1.0 HG2 D:GLU705 4.6 51.7 1.0 CAI D:ZK1901 4.6 60.0 1.0 NAX D:ZK1901 4.6 60.0 1.0 NAP D:ZK1901 4.7 60.0 1.0 HB3 D:GLU705 4.7 51.7 1.0 CAW D:ZK1901 4.7 60.0 1.0 HB2 D:GLU705 4.7 51.7 1.0 OH D:TYR405 4.8 66.5 1.0 HD11 D:LEU498 4.8 46.4 1.0 HD2 D:TYR405 4.8 66.5 1.0 CZ D:TYR405 4.9 66.5 1.0 HD13 D:LEU498 4.9 46.4 1.0 CD2 D:TYR405 5.0 66.5 1.0 HB2 D:MET708 5.0 58.4 1.0 CD1 D:TYR732 5.0 50.2 1.0 CA D:PRO478 5.0 62.7 1.0

D.Zhang, R.Lape, S.A.Shaikh, B.K.Kohegyi, J.F.Watson, O.Cais, T.Nakagawa, I.H.Greger. Modulatory Mechanisms of Tarp Gamma 8-Selective Ampa Receptor Therapeutics. Nat Commun V. 14 1659 2023.
ISSN: ESSN 2041-1723
PubMed: 36966141
DOI: 10.1038/S41467-023-37259-5