Fluorine in PDB 8ayo: Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059

The structure of Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 also contains other interesting chemical elements:

Chlorine

(Cl)

4 atoms

The binding sites of Fluorine atom in the Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 (pdb code 8ayo). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059, PDB code: 8ayo:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ I:F1802 b:27.3 occ:1.00 F1 I:OIJ1802 0.0 27.3 1.0 C21 I:OIJ1802 1.4 27.3 1.0 C22 I:OIJ1802 2.4 27.3 1.0 C20 I:OIJ1802 2.4 27.3 1.0 C23 I:OIJ1802 3.6 27.3 1.0 C19 I:OIJ1802 3.6 27.3 1.0 CG I:LEU210 3.9 26.8 1.0 C18 I:OIJ1802 4.1 27.3 1.0 CD2 I:LEU210 4.3 26.8 1.0 O I:TYR206 4.3 30.0 1.0 CD1 I:ILE213 4.3 26.7 1.0 CD1 I:TYR206 4.4 30.0 1.0 CD1 I:LEU210 4.5 26.8 1.0 N I:LEU210 4.6 26.8 1.0 CB I:TYR206 4.6 30.0 1.0 C I:GLY209 4.9 27.8 1.0 CA I:TYR206 4.9 30.0 1.0 CA I:LEU210 4.9 26.8 1.0 CB I:LEU210 5.0 26.8 1.0

Fluorine binding site 2 out of 2 in the Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Open State GLUA1/A2 Ampa Receptor in Complex with Tarp Gamma 8 and Ligand Jnj-61432059 within 5.0Å range: probe atom residue distance (Å) B Occ J:F1804 b:27.5 occ:1.00 F1 J:OIJ1804 0.0 27.5 1.0 C21 J:OIJ1804 1.4 27.5 1.0 C22 J:OIJ1804 2.4 27.5 1.0 C20 J:OIJ1804 2.4 27.5 1.0 C23 J:OIJ1804 3.6 27.5 1.0 C19 J:OIJ1804 3.6 27.5 1.0 CG J:LEU210 3.9 26.8 1.0 C18 J:OIJ1804 4.1 27.5 1.0 CD2 J:LEU210 4.3 26.8 1.0 O J:TYR206 4.3 30.1 1.0 CD1 J:ILE213 4.3 26.6 1.0 CD1 J:TYR206 4.4 30.1 1.0 CD1 J:LEU210 4.5 26.8 1.0 N J:LEU210 4.6 26.8 1.0 CB J:TYR206 4.6 30.1 1.0 C J:GLY209 4.9 27.9 1.0 CA J:TYR206 4.9 30.1 1.0 CA J:LEU210 4.9 26.8 1.0 CB J:LEU210 5.0 26.8 1.0

D.Zhang, R.Lape, S.A.Shaikh, B.K.Kohegyi, J.F.Watson, O.Cais, T.Nakagawa, I.H.Greger. Modulatory Mechanisms of Tarp Gamma 8-Selective Ampa Receptor Therapeutics. Nat Commun V. 14 1659 2023.
ISSN: ESSN 2041-1723
PubMed: 36966141
DOI: 10.1038/S41467-023-37259-5