Fluorine in PDB 8bw9: Cryo-Em Structure of the Raf Activating Complex Ksr-Mek-Cnk-Hyp

All present enzymatic activity of Cryo-Em Structure of the Raf Activating Complex Ksr-Mek-Cnk-Hyp:
2.7.12.2;

The structure of Cryo-Em Structure of the Raf Activating Complex Ksr-Mek-Cnk-Hyp also contains other interesting chemical elements:

Iodine	(I)	1 atom
Magnesium	(Mg)	1 atom

The binding sites of Fluorine atom in the Cryo-Em Structure of the Raf Activating Complex Ksr-Mek-Cnk-Hyp (pdb code 8bw9). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total only one binding site of Fluorine was determined in the Cryo-Em Structure of the Raf Activating Complex Ksr-Mek-Cnk-Hyp, PDB code: 8bw9:

Fluorine binding site 1 out of 1 in the Cryo-Em Structure of the Raf Activating Complex Ksr-Mek-Cnk-Hyp


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Cryo-Em Structure of the Raf Activating Complex Ksr-Mek-Cnk-Hyp within 5.0Å range: probe atom residue distance (Å) B Occ C:F402 b:150.8 occ:1.00 F18 C:QOM402 0.0 150.8 1.0 C12 C:QOM402 1.4 145.3 1.0 C11 C:QOM402 2.3 141.9 1.0 C13 C:QOM402 2.3 141.9 1.0 O20 C:QOM402 2.5 151.3 1.0 N10 C:QOM402 2.7 147.4 1.0 C14 C:QOM402 3.6 146.3 1.0 C16 C:QOM402 3.6 138.7 1.0 C19 C:QOM402 3.7 149.2 1.0 C05 C:QOM402 3.9 143.0 1.0 C15 C:QOM402 4.1 145.4 1.0 CG C:LYS116 4.1 149.4 1.0 OD1 C:ASP227 4.1 114.5 1.0 CE C:LYS116 4.3 148.3 1.0 C04 C:QOM402 4.3 146.7 1.0 CG2 C:ILE160 4.4 155.0 1.0 CG C:ASP227 4.6 110.6 1.0 CD C:LYS116 4.7 149.1 1.0 CB C:LYS116 4.7 147.2 1.0 N21 C:QOM402 4.8 147.5 1.0 C37 C:QOM402 4.8 146.0 1.0 OD2 C:ASP227 4.9 112.9 1.0 CB C:ILE160 4.9 153.9 1.0 C35 C:QOM402 4.9 145.6 1.0 CD1 C:ILE160 4.9 154.4 1.0

P.Maisonneuve, S.Malha, F.Bergeron-Labrecque, M.Lefrancois, X.I.Ma, G.Arseneault, R.Fronzes, I.Kurinov, F.Sicheri, M.Therrien. The Cnk-Hyp Scaffolding Complex Promotes Raf Activation By Enhancing Ksr-Mek Interaction To Be Published 2024.
DOI: 10.1038/S41594-024-01233-6