Fluorine in PDB 8cgv: Tiamulin Bound to the 50S Subunit

The structure of Tiamulin Bound to the 50S Subunit also contains other interesting chemical elements:

Magnesium	(Mg)	219 atoms
Zinc	(Zn)	1 atom
Potassium	(K)	83 atoms

The binding sites of Fluorine atom in the Tiamulin Bound to the 50S Subunit (pdb code 8cgv). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Tiamulin Bound to the 50S Subunit, PDB code: 8cgv:
Jump to Fluorine binding site number: 1; 2;

Fluorine binding site 1 out of 2 in the Tiamulin Bound to the 50S Subunit


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Tiamulin Bound to the 50S Subunit within 5.0Å range: probe atom residue distance (Å) B Occ a:F3001 b:64.6 occ:1.00 F1 a:P8F3001 0.0 64.6 1.0 C21 a:P8F3001 1.4 63.2 1.0 C22 a:P8F3001 2.4 60.5 1.0 C20 a:P8F3001 2.4 59.1 1.0 C8 a:A1028 3.1 25.7 1.0 N3 a:P8F3001 3.2 56.5 1.0 O4' a:A1028 3.3 28.8 1.0 O3' a:A1027 3.4 45.9 1.0 C1' a:A1027 3.5 45.3 1.0 O a:HOH6516 3.6 52.4 1.0 O4' a:A1027 3.7 43.8 1.0 N7 a:A1028 3.7 26.4 1.0 N9 a:A1028 3.8 25.4 1.0 O5' a:A1028 3.8 42.0 1.0 N3 a:A1027 3.9 43.1 1.0 C1' a:A1028 4.1 26.1 1.0 C5' a:A1028 4.2 34.0 1.0 C3' a:A1027 4.2 45.6 1.0 O3' a:G2487 4.2 27.6 1.0 C4' a:A1027 4.2 43.6 1.0 C2' a:A1027 4.3 45.9 1.0 OP1 a:G2488 4.3 29.9 1.0 O2' a:A1027 4.3 46.9 1.0 C19 a:P8F3001 4.3 55.3 1.0 C4' a:A1028 4.4 30.9 1.0 P a:A1028 4.4 54.8 1.0 N9 a:A1027 4.4 42.9 1.0 N6 a:A1126 4.4 23.5 1.0 C4 a:A1027 4.6 42.0 1.0 C5 a:A1028 4.7 23.9 1.0 C4 a:A1028 4.7 23.6 1.0 C2 a:A1027 4.9 42.0 1.0 P a:G2488 5.0 26.1 1.0 C4' a:G2487 5.0 26.5 1.0

Fluorine binding site 2 out of 2 in the Tiamulin Bound to the 50S Subunit


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Tiamulin Bound to the 50S Subunit within 5.0Å range: probe atom residue distance (Å) B Occ a:F3002 b:94.9 occ:1.00 F1 a:P8F3002 0.0 94.9 1.0 C21 a:P8F3002 1.4 95.0 1.0 C20 a:P8F3002 2.4 92.2 1.0 C22 a:P8F3002 2.4 93.3 1.0 N3 a:P8F3002 2.9 86.9 1.0 O a:HOH5340 4.1 29.7 1.0 C19 a:P8F3002 4.3 77.9 1.0 OP1 a:G2458 4.5 27.4 1.0 O4 b:U89 4.8 108.4 1.0

H.Paternoga, C.Crowe-Mcauliffe, L.V.Bock, T.O.Koller, M.Morici, B.Beckert, A.G.Myasnikov, H.Grubmueller, J.Novacek, D.N.Wilson. Structural Conservation of Antibiotic Interaction with Ribosomes To Be Published.