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Fluorine in PDB 8deg: Crystal Structure of Dlk in Complex with Inhibitor DN0011197Enzymatic activity of Crystal Structure of Dlk in Complex with Inhibitor DN0011197
All present enzymatic activity of Crystal Structure of Dlk in Complex with Inhibitor DN0011197:
2.7.11.25; Protein crystallography data
The structure of Crystal Structure of Dlk in Complex with Inhibitor DN0011197, PDB code: 8deg
was solved by
A.Srivastava,
K.Lexa,
J.De Vicente,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the Crystal Structure of Dlk in Complex with Inhibitor DN0011197
(pdb code 8deg). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 2 binding sites of Fluorine where determined in the Crystal Structure of Dlk in Complex with Inhibitor DN0011197, PDB code: 8deg: Jump to Fluorine binding site number: 1; 2; Fluorine binding site 1 out of 2 in 8degGo back to Fluorine Binding Sites List in 8deg
Fluorine binding site 1 out
of 2 in the Crystal Structure of Dlk in Complex with Inhibitor DN0011197
Mono view Stereo pair view
Fluorine binding site 2 out of 2 in 8degGo back to Fluorine Binding Sites List in 8deg
Fluorine binding site 2 out
of 2 in the Crystal Structure of Dlk in Complex with Inhibitor DN0011197
Mono view Stereo pair view
Reference:
R.A.Craig 2Nd,
B.M.Fox,
C.Hu,
K.W.Lexa,
M.Osipov,
A.P.Thottumkara,
M.Larhammar,
T.Miyamoto,
A.Rana,
L.A.Kane,
E.Yulyaningsih,
H.Solanoy,
H.Nguyen,
R.Chau,
T.Earr,
Y.Kajiwara,
D.Fleck,
A.Lucas,
P.C.G.Haddick,
R.H.Takahashi,
V.Tong,
J.Wang,
M.J.Canet,
S.B.Poda,
K.Scearce-Levie,
A.Srivastava,
Z.K.Sweeney,
M.Xu,
R.Zhang,
J.He,
Y.Lei,
Z.Zhuo,
J.De Vicente.
Discovery of Potent and Selective Dual Leucine Zipper Kinase/Leucine Zipper-Bearing Kinase Inhibitors with Neuroprotective Properties in in Vitro and in Vivo Models of Amyotrophic Lateral Sclerosis. J.Med.Chem. V. 65 16290 2022.
Page generated: Wed Apr 5 02:12:57 2023
ISSN: ISSN 0022-2623 PubMed: 36469401 DOI: 10.1021/ACS.JMEDCHEM.2C01056 |
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