Fluorine in PDB 8dhb: Active Flcn Gap Complex

All present enzymatic activity of Active Flcn Gap Complex:
2.5.1.18;

The binding sites of Fluorine atom in the Active Flcn Gap Complex (pdb code 8dhb). This binding sites where shown within 5.0 Angstroms radius around Fluorine atom.
In total 3 binding sites of Fluorine where determined in the Active Flcn Gap Complex, PDB code: 8dhb:
Jump to Fluorine binding site number: 1; 2; 3;

Fluorine binding site 1 out of 3 in the Active Flcn Gap Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of Active Flcn Gap Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:F502 b:70.4 occ:1.00 F1 A:BEF502 0.0 70.4 1.0 BE A:BEF502 1.5 70.9 1.0 F3 A:BEF502 2.5 71.4 1.0 F2 A:BEF502 2.6 71.0 1.0 O12 A:CZC501 2.7 64.3 1.0 NH1 J:ARG164 3.1 20.4 1.0 CG2 A:THR96 3.7 5.7 1.0 N A:ASN97 3.8 5.8 1.0 CB A:ARG70 3.9 20.4 1.0 N A:GLY119 3.9 5.2 1.0 CA A:ARG70 4.0 20.4 1.0 P2 A:CZC501 4.0 64.1 1.0 CZ J:ARG164 4.1 20.4 1.0 NH2 J:ARG164 4.1 20.4 1.0 CA A:THR96 4.1 5.7 1.0 OD1 A:ASN97 4.2 5.8 1.0 CB A:THR96 4.5 5.7 1.0 O7 A:CZC501 4.5 63.7 1.0 C A:THR96 4.5 5.7 1.0 O10 A:CZC501 4.5 64.2 1.0 CB A:ASN97 4.6 5.8 1.0 N A:ARG71 4.6 20.4 1.0 CA A:PRO118 4.6 9.4 1.0 CA A:GLY119 4.7 5.2 1.0 OE1 A:GLN120 4.8 2.4 1.0 C A:PRO118 4.8 9.4 1.0 CA A:ASN97 4.8 5.8 1.0 CG A:ASN97 4.8 5.8 1.0 OG1 A:THR96 4.9 5.7 1.0 O A:LEU69 4.9 10.4 1.0 C A:ARG70 4.9 20.4 1.0 O A:SER95 4.9 13.4 1.0 N A:ARG70 5.0 20.4 1.0 O A:PHE117 5.0 20.4 1.0 NE2 A:GLN120 5.0 2.4 1.0

Fluorine binding site 2 out of 3 in the Active Flcn Gap Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of Active Flcn Gap Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:F502 b:71.0 occ:1.00 F2 A:BEF502 0.0 71.0 1.0 BE A:BEF502 1.6 70.9 1.0 OD1 A:ASN97 2.3 5.8 1.0 N A:ASN97 2.5 5.8 1.0 F3 A:BEF502 2.5 71.4 1.0 F1 A:BEF502 2.6 70.4 1.0 CG A:ASN97 2.7 5.8 1.0 O12 A:CZC501 2.9 64.3 1.0 CB A:ASN97 3.1 5.8 1.0 O10 A:CZC501 3.1 64.2 1.0 CA A:ASN97 3.3 5.8 1.0 NH2 J:ARG164 3.4 20.4 1.0 C A:THR96 3.4 5.7 1.0 P2 A:CZC501 3.5 64.1 1.0 CA A:THR96 3.6 5.7 1.0 NH1 J:ARG164 3.7 20.4 1.0 ND2 A:ASN97 3.7 5.8 1.0 O7 A:CZC501 3.9 63.7 1.0 CZ J:ARG164 4.0 20.4 1.0 O A:THR96 4.4 5.7 1.0 CG2 A:THR96 4.5 5.7 1.0 OG A:SER75 4.5 20.4 1.0 N A:THR96 4.5 5.7 1.0 C A:ASN97 4.6 5.8 1.0 O9 A:CZC501 4.6 63.6 1.0 CB A:THR96 4.7 5.7 1.0 O A:GLU94 4.8 5.4 1.0 O A:PHE117 4.8 20.4 1.0 O A:ASN97 4.8 5.8 1.0 O11 A:CZC501 4.9 64.2 1.0 P1 A:CZC501 4.9 63.3 1.0

Fluorine binding site 3 out of 3 in the Active Flcn Gap Complex


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of Active Flcn Gap Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:F502 b:71.4 occ:1.00 F3 A:BEF502 0.0 71.4 1.0 BE A:BEF502 1.5 70.9 1.0 O12 A:CZC501 2.5 64.3 1.0 OD1 A:ASN97 2.5 5.8 1.0 F2 A:BEF502 2.5 71.0 1.0 F1 A:BEF502 2.5 70.4 1.0 O A:PHE117 2.6 20.4 1.0 CB A:ASN97 3.2 5.8 1.0 CG A:ASN97 3.2 5.8 1.0 O10 A:CZC501 3.3 64.2 1.0 P2 A:CZC501 3.3 64.1 1.0 CA A:PRO118 3.5 9.4 1.0 N A:GLY119 3.5 5.2 1.0 CD A:LYS74 3.7 14.6 1.0 C A:PHE117 3.7 20.4 1.0 NZ A:LYS74 3.7 14.6 1.0 C A:PRO118 3.8 9.4 1.0 N A:ASN97 3.9 5.8 1.0 N A:PRO118 4.0 9.4 1.0 CE A:LYS74 4.1 14.6 1.0 CA A:ASN97 4.1 5.8 1.0 O11 A:CZC501 4.2 64.2 1.0 ND2 A:ASN97 4.5 5.8 1.0 O7 A:CZC501 4.6 63.7 1.0 CA A:GLY119 4.6 5.2 1.0 CG A:LYS74 4.7 14.6 1.0 O A:LEU69 4.7 10.4 1.0 CB A:PRO118 4.7 9.4 1.0 O A:PRO118 4.8 9.4 1.0 CB A:LYS74 4.8 14.6 1.0 O A:ASN97 5.0 5.8 1.0 C A:ASN97 5.0 5.8 1.0 CA A:PHE117 5.0 20.4 1.0

R.M.Jansen, R.Peruzzo, S.A.Fromm, A.L.Yokom, R.Zoncu, J.H.Hurley. Structural Basis For Flcn Ragc Gap Activation in Mit-Tfe Substrate-Selective MTORC1 Regulation. Sci Adv V. 8 D2926 2022.
ISSN: ESSN 2375-2548
PubMed: 36103527
DOI: 10.1126/SCIADV.ADD2926