Fluorine in PDB 8eio: The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Elexacaftor (Vx-445), Lumacaftor (Vx-809) and Atp/Mg

Enzymatic activity of The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Elexacaftor (Vx-445), Lumacaftor (Vx-809) and Atp/Mg

Other elements in 8eio:

Fluorine Binding Sites:

Fluorine binding site 1 out of 5 in 8eio

Fluorine Binding Sites List in 8eio

Fluorine binding site 1 out of 5 in the The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Elexacaftor (Vx-445), Lumacaftor (Vx-809) and Atp/Mg


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 1 of The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Elexacaftor (Vx-445), Lumacaftor (Vx-809) and Atp/Mg within 5.0Å range: probe atom residue distance (Å) B Occ A:F1507 b:60.8 occ:1.00 F1 A:VX81507 0.0 60.8 1.0 C20 A:VX81507 1.4 60.0 1.0 F2 A:VX81507 2.2 60.6 1.0 O5 A:VX81507 2.3 62.3 1.0 O4 A:VX81507 2.3 59.6 1.0 OG A:SER364 3.1 47.8 1.0 C16 A:VX81507 3.2 58.0 1.0 C17 A:VX81507 3.2 60.4 1.0 CD1 A:LEU195 3.6 54.5 1.0 CB A:SER364 3.8 41.6 1.0 CG2 A:THR360 3.9 30.1 1.0 CG A:LEU195 4.0 47.7 1.0 CB A:ALA198 4.2 34.9 1.0 CA A:LEU195 4.3 39.0 1.0 N A:LEU195 4.3 34.7 1.0 C A:GLY194 4.3 44.1 1.0 O A:GLY194 4.4 51.9 1.0 C15 A:VX81507 4.4 59.2 1.0 C18 A:VX81507 4.4 57.5 1.0 CB A:LEU195 4.8 40.0 1.0 CA A:GLY194 4.9 43.1 1.0 O A:THR360 4.9 35.4 1.0

Fluorine binding site 2 out of 5 in 8eio

Fluorine Binding Sites List in 8eio

Fluorine binding site 2 out of 5 in the The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Elexacaftor (Vx-445), Lumacaftor (Vx-809) and Atp/Mg


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 2 of The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Elexacaftor (Vx-445), Lumacaftor (Vx-809) and Atp/Mg within 5.0Å range: probe atom residue distance (Å) B Occ A:F1507 b:60.6 occ:1.00 F2 A:VX81507 0.0 60.6 1.0 C20 A:VX81507 1.4 60.0 1.0 F1 A:VX81507 2.2 60.8 1.0 O4 A:VX81507 2.3 59.6 1.0 O5 A:VX81507 2.3 62.3 1.0 C16 A:VX81507 3.3 58.0 1.0 C17 A:VX81507 3.3 60.4 1.0 CD2 A:TRP361 3.3 37.1 1.0 CB A:ALA198 3.5 34.9 1.0 CE2 A:TRP361 3.5 35.3 1.0 CE3 A:TRP361 3.5 39.8 1.0 CG A:TRP361 3.8 28.4 1.0 CG2 A:THR360 3.8 30.1 1.0 OG A:SER364 3.8 47.8 1.0 CZ3 A:TRP361 3.9 39.6 1.0 CZ2 A:TRP361 3.9 35.5 1.0 CA A:TRP361 4.0 26.6 1.0 NE1 A:TRP361 4.0 42.7 1.0 CB A:SER364 4.1 41.6 1.0 CH2 A:TRP361 4.1 42.4 1.0 CD1 A:TRP361 4.1 33.9 1.0 N A:TRP361 4.2 33.3 1.0 O A:THR360 4.2 35.4 1.0 C A:THR360 4.3 28.9 1.0 CB A:TRP361 4.5 28.5 1.0 CA A:ALA198 4.5 28.2 1.0 C15 A:VX81507 4.6 59.2 1.0 C18 A:VX81507 4.6 57.5 1.0 CB A:THR360 4.7 29.1 1.0

Fluorine binding site 3 out of 5 in 8eio

Fluorine Binding Sites List in 8eio

Fluorine binding site 3 out of 5 in the The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Elexacaftor (Vx-445), Lumacaftor (Vx-809) and Atp/Mg


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 3 of The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Elexacaftor (Vx-445), Lumacaftor (Vx-809) and Atp/Mg within 5.0Å range: probe atom residue distance (Å) B Occ A:F1508 b:67.7 occ:1.00 F A:WJX1508 0.0 67.7 1.0 C17 A:WJX1508 1.3 68.0 1.0 F2 A:WJX1508 2.1 68.2 1.0 F1 A:WJX1508 2.1 69.9 1.0 C14 A:WJX1508 2.4 65.4 1.0 C15 A:WJX1508 2.7 59.4 1.0 CD1 A:ILE132 2.8 48.9 1.0 C16 A:WJX1508 3.2 59.9 1.0 C13 A:WJX1508 3.6 65.3 1.0 CG1 A:ILE132 4.1 49.4 1.0 CG2 A:ILE132 4.3 44.1 1.0 O A:WJX1508 4.7 65.5 1.0 CB A:ILE132 4.8 44.1 1.0

Fluorine binding site 4 out of 5 in 8eio

Fluorine Binding Sites List in 8eio

Fluorine binding site 4 out of 5 in the The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Elexacaftor (Vx-445), Lumacaftor (Vx-809) and Atp/Mg


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 4 of The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Elexacaftor (Vx-445), Lumacaftor (Vx-809) and Atp/Mg within 5.0Å range: probe atom residue distance (Å) B Occ A:F1508 b:69.9 occ:1.00 F1 A:WJX1508 0.0 69.9 1.0 C17 A:WJX1508 1.3 68.0 1.0 F A:WJX1508 2.1 67.7 1.0 F2 A:WJX1508 2.1 68.2 1.0 C14 A:WJX1508 2.4 65.4 1.0 C13 A:WJX1508 2.6 65.3 1.0 C15 A:WJX1508 3.2 59.4 1.0 C16 A:WJX1508 3.7 59.9 1.0 O A:WJX1508 4.0 65.5 1.0 CD1 A:ILE132 4.7 48.9 1.0 CE1 A:PHE16 4.9 49.3 1.0 CZ A:PHE16 4.9 51.0 1.0 C12 A:WJX1508 4.9 59.4 1.0

Fluorine binding site 5 out of 5 in 8eio

Fluorine Binding Sites List in 8eio

Fluorine binding site 5 out of 5 in the The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Elexacaftor (Vx-445), Lumacaftor (Vx-809) and Atp/Mg


Mono view


Stereo pair view

A full contact list of Fluorine with other atoms in the F binding site number 5 of The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Elexacaftor (Vx-445), Lumacaftor (Vx-809) and Atp/Mg within 5.0Å range: probe atom residue distance (Å) B Occ A:F1508 b:68.2 occ:1.00 F2 A:WJX1508 0.0 68.2 1.0 C17 A:WJX1508 1.3 68.0 1.0 F A:WJX1508 2.1 67.7 1.0 F1 A:WJX1508 2.1 69.9 1.0 C14 A:WJX1508 2.4 65.4 1.0 C16 A:WJX1508 2.7 59.9 1.0 C13 A:WJX1508 3.1 65.3 1.0 CD1 A:ILE132 3.4 48.9 1.0 C15 A:WJX1508 3.7 59.4 1.0 O A:WJX1508 4.5 65.5 1.0 CG2 A:ILE132 4.5 44.1 1.0 CG A:MET1105 4.7 50.9 1.0 CG1 A:ILE132 4.8 49.4 1.0 CE A:MET1105 4.9 51.4 1.0

Reference: