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Atomistry » Fluorine » PDB 8e26-8ekt » 8eiq | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Fluorine » PDB 8e26-8ekt » 8eiq » |
Fluorine in PDB 8eiq: The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Trikafta [Elexacaftor (Vx-445), Tezacaftor (Vx-661), Ivacaftor (Vx-770)] and Atp/MgEnzymatic activity of The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Trikafta [Elexacaftor (Vx-445), Tezacaftor (Vx-661), Ivacaftor (Vx-770)] and Atp/Mg
All present enzymatic activity of The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Trikafta [Elexacaftor (Vx-445), Tezacaftor (Vx-661), Ivacaftor (Vx-770)] and Atp/Mg:
5.6.1.6; Other elements in 8eiq:
The structure of The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Trikafta [Elexacaftor (Vx-445), Tezacaftor (Vx-661), Ivacaftor (Vx-770)] and Atp/Mg also contains other interesting chemical elements:
Fluorine Binding Sites:
The binding sites of Fluorine atom in the The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Trikafta [Elexacaftor (Vx-445), Tezacaftor (Vx-661), Ivacaftor (Vx-770)] and Atp/Mg
(pdb code 8eiq). This binding sites where shown within
5.0 Angstroms radius around Fluorine atom.
In total 6 binding sites of Fluorine where determined in the The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Trikafta [Elexacaftor (Vx-445), Tezacaftor (Vx-661), Ivacaftor (Vx-770)] and Atp/Mg, PDB code: 8eiq: Jump to Fluorine binding site number: 1; 2; 3; 4; 5; 6; Fluorine binding site 1 out of 6 in 8eiqGo back to Fluorine Binding Sites List in 8eiq
Fluorine binding site 1 out
of 6 in the The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Trikafta [Elexacaftor (Vx-445), Tezacaftor (Vx-661), Ivacaftor (Vx-770)] and Atp/Mg
Mono view Stereo pair view
Fluorine binding site 2 out of 6 in 8eiqGo back to Fluorine Binding Sites List in 8eiq
Fluorine binding site 2 out
of 6 in the The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Trikafta [Elexacaftor (Vx-445), Tezacaftor (Vx-661), Ivacaftor (Vx-770)] and Atp/Mg
Mono view Stereo pair view
Fluorine binding site 3 out of 6 in 8eiqGo back to Fluorine Binding Sites List in 8eiq
Fluorine binding site 3 out
of 6 in the The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Trikafta [Elexacaftor (Vx-445), Tezacaftor (Vx-661), Ivacaftor (Vx-770)] and Atp/Mg
Mono view Stereo pair view
Fluorine binding site 4 out of 6 in 8eiqGo back to Fluorine Binding Sites List in 8eiq
Fluorine binding site 4 out
of 6 in the The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Trikafta [Elexacaftor (Vx-445), Tezacaftor (Vx-661), Ivacaftor (Vx-770)] and Atp/Mg
Mono view Stereo pair view
Fluorine binding site 5 out of 6 in 8eiqGo back to Fluorine Binding Sites List in 8eiq
Fluorine binding site 5 out
of 6 in the The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Trikafta [Elexacaftor (Vx-445), Tezacaftor (Vx-661), Ivacaftor (Vx-770)] and Atp/Mg
Mono view Stereo pair view
Fluorine binding site 6 out of 6 in 8eiqGo back to Fluorine Binding Sites List in 8eiq
Fluorine binding site 6 out
of 6 in the The Complex of Phosphorylated Human Delta F508 Cystic Fibrosis Transmembrane Conductance Regulator (Cftr) with Trikafta [Elexacaftor (Vx-445), Tezacaftor (Vx-661), Ivacaftor (Vx-770)] and Atp/Mg
Mono view Stereo pair view
Reference:
K.Fiedorczuk,
J.Chen.
Molecular Structures Reveal Synergistic Rescue of Delta 508 Cftr By Trikafta Modulators. Science V. 378 284 2022.
Page generated: Fri Aug 2 18:11:26 2024
ISSN: ESSN 1095-9203 PubMed: 36264792 DOI: 10.1126/SCIENCE.ADE2216 |
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